DataVXSmall MethodsPaper
journal article·2025-01

Plasma Membrane‐Derived Biomimetic Apoptotic Nanovesicles Targeting Inflammation and Cartilage Degeneration for Osteoarthritis

Zongyi Li, Quhan Cheng, Luoyao Lin, Xiaoling Fu, Yingjun Wang

Small Methods· Volume 9· Issue 1
Publisher page
Source abstract

Abstract

Abstract Osteoarthritis (OA) is a degenerative whole‐joint disease in which the synovium and joint cartilage become inflamed and damaged. The essential role of inflammation in the development of OA has been recognized recently. Accordingly, simultaneous regulation of local inflammation and tissue degeneration is proposed as a promising therapeutic strategy. Herein, multifunctional biomimetic apoptotic nanovesicles (Apo‐NVs) are constructed with plasma membrane derived from apoptotic T cells. The anti‐inflammatory microRNA‐124 is further encapsulated into Apo‐NVs in the hope of achieving an enhanced immunomodulatory effect. It is found that apoptotic nanovesicles, including Apo‐NVs and Apo‐NVs‐miR‐124, both efficiently promote the M2 repolarization of M1 macrophages and inhibit the degenerative phenotype of chondrocytes. Further in vivo studies show that Apo‐NVs and Apo‐NVs‐miR‐124 alleviate synovial inflammation and protect cartilage tissue from degeneration in OA mice. The study highlights the potential of Apo‐NVs in treating OA and other inflammation‐related diseases.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease · Phagocytosis and Immune Regulation · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China

National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction Guangzhou 510006 China

Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology Guangzhou 510006 China

Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciences Nankai University Tianjin 300071 China

School of Biomedical Sciences and Engineering South China University of Technology Guangzhou International Campus Guangzhou 511442 China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Basic and Applied Basic Research Foundation of Guangdong Province · Key Technologies Research and Development Program of Guangzhou Municipality

References (53)

Show source-provided references
1. 10.1038/nrrheum.2016.13610.1038/nrrheum.2016.136 ↗
2. 10.1038/ncomms1501910.1038/ncomms15019 ↗
3. 10.1016/S0140-6736(14)60802-310.1016/S0140-6736(14)60802-3 ↗
4. 10.1002/adma.20220271510.1002/adma.202202715 ↗
5. 10.1038/s41584-022-00749-910.1038/s41584-022-00749-9 ↗
6. 10.1126/sciadv.abk001110.1126/sciadv.abk0011 ↗
7. 10.1002/art.178039051310.1002/art.1780390513 ↗
8. 10.3109/03008207.2012.66100110.3109/03008207.2012.661001 ↗
9. 10.1097/BOR.0b013e328349c2b110.1097/BOR.0b013e328349c2b1 ↗
10. 10.1038/s41556-019-0431-110.1038/s41556-019-0431-1 ↗
11. 10.1038/3702210.1038/37022 ↗
12. 10.1002/sita.20050007110.1002/sita.200500071 ↗
13. 10.1038/nri95710.1038/nri957 ↗
14. 10.1016/j.bioactmat.2021.10.02510.1016/j.bioactmat.2021.10.025 ↗
15. 10.1016/j.bioactmat.2022.04.02210.1016/j.bioactmat.2022.04.022 ↗
16. 10.1038/s41422-018-0070-210.1038/s41422-018-0070-2 ↗
17. 10.7150/thno.4517010.7150/thno.45170 ↗
18. 10.1186/s13287-020-02014-w10.1186/s13287-020-02014-w ↗
19. 10.1126/scisignal.200063410.1126/scisignal.2000634 ↗
20. 10.1038/nri360710.1038/nri3607 ↗
21. 10.3389/fimmu.2017.0090910.3389/fimmu.2017.00909 ↗
22. 10.1016/j.actbio.2020.03.04110.1016/j.actbio.2020.03.041 ↗
23. 10.1073/pnas.101562310810.1073/pnas.1015623108 ↗
24. 10.1016/j.jconrel.2019.10.04310.1016/j.jconrel.2019.10.043 ↗
25. 10.1038/s41590-022-01387-910.1038/s41590-022-01387-9 ↗
26. 10.1126/sciadv.aba298710.1126/sciadv.aba2987 ↗
27. 10.1038/sj.onc.120443610.1038/sj.onc.1204436 ↗
28. 10.1002/adma.20160217310.1002/adma.201602173 ↗
29. 10.1016/j.biomaterials.2020.12053910.1016/j.biomaterials.2020.120539 ↗
30. 10.1021/acsnano.0c0092110.1021/acsnano.0c00921 ↗
31. 10.1016/j.joca.2020.01.00710.1016/j.joca.2020.01.007 ↗
32. 10.1038/s41586-019-1471-110.1038/s41586-019-1471-1 ↗
33. 10.1002/art.178039091410.1002/art.1780390914 ↗
34. 10.1016/j.joca.2017.01.01110.1016/j.joca.2017.01.011 ↗
35. 10.1136/annrheumdis-2018-21345010.1136/annrheumdis-2018-213450 ↗
36. 10.1038/s41420-021-00763-y10.1038/s41420-021-00763-y ↗
37. 10.1016/j.biopha.2020.11119810.1016/j.biopha.2020.111198 ↗
38. 10.3389/fimmu.2016.0040610.3389/fimmu.2016.00406 ↗
39. 10.1172/JCI111210.1172/JCI1112 ↗
40. 10.4049/jimmunol.130061310.4049/jimmunol.1300613 ↗
41. 10.1016/S1097-2765(04)00237-010.1016/S1097-2765(04)00237-0 ↗
42. 10.1038/3501108410.1038/35011084 ↗
43. 10.1016/S0092-8674(01)00237-910.1016/S0092-8674(01)00237-9 ↗
44. 10.1016/j.biomaterials.2020.11993110.1016/j.biomaterials.2020.119931 ↗
45. 10.1002/adfm.20180755910.1002/adfm.201807559 ↗
46. 10.1016/j.biomaterials.2018.07.01110.1016/j.biomaterials.2018.07.011 ↗
47. 10.1080/14728222.2018.144806210.1080/14728222.2018.1448062 ↗
48. 10.1080/21691401.2019.162455910.1080/21691401.2019.1624559 ↗
49. 10.1136/annrheumdis-2015-eular.205510.1136/annrheumdis-2015-eular.2055 ↗
50. Lieben L. · Nat Rev Rheumatol. · 2016 · 12 · 70
51. 10.1016/j.joca.2020.04.00310.1016/j.joca.2020.04.003 ↗
52. 10.1126/sciadv.abo528410.1126/sciadv.abo5284 ↗
53. 10.1002/jor.110010010710.1002/jor.1100100107 ↗