journal article·2018-12

Local Delivery and Sustained‐Release of Nitric Oxide Donor Loaded in Mesoporous Silica Particles for Efficient Treatment of Primary Open‐Angle Glaucoma

Chunchun Hu, Jianguo Sun, Yu Zhang, Jian Chen, Yuan Lei, Xinghuai Sun, Yonghui Deng

Advanced Healthcare Materials· Volume 7· Issue 23
Publisher page

Abstract

Abstract Nitric oxide (NO) donors are ideal drug candidates for reducing intraocular pressure in the treatment of glaucoma. However, poor cornea penetration, short duration of efficacy, and narrow therapeutic index of most NO donors obstruct their clinical applications in glaucoma treatment. This study reports a novel NO donor delivery system based on mesoporous silica nanoparticles that can readily overcome the above difficulties and deliver the NO‐donating drug sodium nitroprusside to the target tissues (trabecular meshwork and Schlemm's canal). Mesoporous silica nanoparticles loaded with sodium nitroprusside can produce more exogenous NO and sustain higher NO concentration in animal eye models, which significantly extend the duration of intraocular pressure reduction from 3 to 48 h with only 1/40 of the dose of sodium nitroprusside solution. These findings open up the possibility of mesoporous silica nanoparticles loading sodium nitroprusside for effective management of ocular hypertension.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Glaucoma and retinal disorders · Ocular Surface and Contact Lens · Corneal surgery and disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ophthalmology & Visual Science Eye Institute Eye & ENT Hospital Shanghai Medical College Fudan University Shanghai 200031 China

Key NHC Laboratory of Myopia (Fudan University) Laboratory of Myopia Chinese Academy of Medical Sciences Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University) Shanghai 200031 China

Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials iChEM Fudan University Shanghai 200433 China

School of Energy and Power Engineering, the University of Shanghai for Science and Technology Shanghai 200093 China

State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai 200032 China

State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China

Funding

National Natural Science Foundation of China · Ministry of Science and Technology of the People's Republic of China · BrightFocus Foundation · Shanghai Municipal Health Bureau · Fudan University · Natural Science Foundation of Shanghai

References (60)

Show source-provided references
1. 10.1056/NEJMra080463010.1056/NEJMra0804630 ↗
2. Quigley H. A. · Br. J. Pharmacol. · 2006 · 90 · 262
3. 10.1016/j.exer.2009.02.00710.1016/j.exer.2009.02.007 ↗
4. 10.1159/00045352710.1159/000453527 ↗
5. 10.1097/ICU.000000000000034610.1097/ICU.0000000000000346 ↗
6. 10.1038/nrd374510.1038/nrd3745 ↗
7. 10.1080/14656566.2017.129365410.1080/14656566.2017.1293654 ↗
8. 10.1007/s40265-018-0914-610.1007/s40265-018-0914-6 ↗
9. Wiederholt M. · Invest. Ophthalmol. Visual Sci. · 1994 · 35 · 2515
10. 10.1152/ajpcell.00363.200710.1152/ajpcell.00363.2007 ↗
11. 10.1007/s00417-002-0559-710.1007/s00417-002-0559-7 ↗
12. 10.1021/cr000040l10.1021/cr000040l ↗
13. 10.1038/sj.bjp.070722410.1038/sj.bjp.0707224 ↗
14. 10.1089/jop.2009.012010.1089/jop.2009.0120 ↗
15. 10.1002/adma.20160493210.1002/adma.201604932 ↗
16. 10.1016/j.exer.2010.12.00310.1016/j.exer.2010.12.003 ↗
17. 10.4103/0970-9185.14279910.4103/0970-9185.142799 ↗
18. 10.1016/j.exer.2013.12.01210.1016/j.exer.2013.12.012 ↗
19. 10.1039/c2cs15271a10.1039/c2cs15271a ↗
20. 10.1517/1474033090308171710.1517/14740330903081717 ↗
21. 10.1016/j.ophtha.2015.03.02610.1016/j.ophtha.2015.03.026 ↗
22. 10.1089/1080768026036268710.1089/10807680260362687 ↗
23. 10.1016/j.jcrs.2010.12.03710.1016/j.jcrs.2010.12.037 ↗
24. 10.1007/s13346-016-0339-210.1007/s13346-016-0339-2 ↗
25. 10.1097/00000539-199507000-0003110.1097/00000539-199507000-00031 ↗
26. 10.1016/j.addr.2012.07.01810.1016/j.addr.2012.07.018 ↗
27. 10.1002/adhm.20170083110.1002/adhm.201700831 ↗
28. 10.1021/jacs.7b0146410.1021/jacs.7b01464 ↗
29. 10.1021/acs.langmuir.8b0105110.1021/acs.langmuir.8b01051 ↗
30. 10.1016/j.micromeso.2009.11.01510.1016/j.micromeso.2009.11.015 ↗
31. 10.1002/adma.20120529210.1002/adma.201205292 ↗
32. 10.1002/adma.20110476310.1002/adma.201104763 ↗
33. 10.1021/jacs.7b0905510.1021/jacs.7b09055 ↗
34. 10.1016/j.biomaterials.2016.11.00610.1016/j.biomaterials.2016.11.006 ↗
35. 10.1039/C5CE02592C10.1039/C5CE02592C ↗
36. 10.1039/C7TB01217A10.1039/C7TB01217A ↗
37. 10.1016/j.msec.2017.03.03610.1016/j.msec.2017.03.036 ↗
38. 10.1016/j.apsb.2016.09.00110.1016/j.apsb.2016.09.001 ↗
39. 10.1021/acs.chemmater.6b0049910.1021/acs.chemmater.6b00499 ↗
40. 10.3109/07388551.2012.68586010.3109/07388551.2012.685860 ↗
41. 10.1002/jps.260073063610.1002/jps.2600730636 ↗
42. Kizalaite A. · Biol. Trace Elem. Res. · 2018
43. 10.1016/j.jcis.2016.06.00410.1016/j.jcis.2016.06.004 ↗
44. 10.1038/srep3776210.1038/srep37762 ↗
45. 10.1016/j.nano.2015.03.00410.1016/j.nano.2015.03.004 ↗
46. 10.1002/smll.20080046110.1002/smll.200800461 ↗
47. 10.1002/smll.20130100410.1002/smll.201301004 ↗
48. 10.2147/IJN.S7611410.2147/IJN.S76114 ↗
49. 10.1021/tx300166u10.1021/tx300166u ↗
50. 10.1167/iovs.10-570310.1167/iovs.10-5703 ↗
51. 10.1038/ng.66110.1038/ng.661 ↗
52. 10.1167/iovs.15-1884110.1167/iovs.15-18841 ↗
53. 10.1016/j.preteyeres.2016.12.00410.1016/j.preteyeres.2016.12.004 ↗
54. 10.1167/iovs.16-2107210.1167/iovs.16-21072 ↗
55. 10.1167/iovs.15-1656410.1167/iovs.15-16564 ↗
56. 10.1016/j.jchromb.2006.07.05410.1016/j.jchromb.2006.07.054 ↗
57. 10.1076/ceyr.26.2.119.1451110.1076/ceyr.26.2.119.14511 ↗
58. 10.1167/iovs.08-275010.1167/iovs.08-2750 ↗
59. 10.1089/10807680231723317110.1089/108076802317233171 ↗
60. 10.1167/iovs.12-1149110.1167/iovs.12-11491 ↗