Biodegradable Optical Fiber in a Soft Optoelectronic Device for Wireless Optogenetic Applications

Optogenetics is a new neuroscience technology that uses light-responsive proteins to stimulate neurons with light and control the emotions and/or behavior of animals. There are a few approaches to deliver light to neurons in vivo, including a using an optical fiber that can send light from an external source to a target neuron, directly inserting a light-emitting device, and shooting light to penetrate tissue from the outside. Among these methods, inserting a wireless light-emitting device that is capable of being used for an experiment while leaving an animal completely free is a method that has been studied in recent years. At the same time, the possibility of causing mechanical and thermal damage to neural tissues has been highlighted as an issue due to the stiffness of robust injection tools and the photoelectric efficiency of light-emitting diodes (LEDs). In this study, we developed a device that can send light from a wireless light-emitting device to a target neuron without mechanical and thermal effects and analyzed the optical and thermal characteristics of the device to be used for optogenetic studies.