DataVXChemistry of MaterialsPaper
journal article·2018-09-11

Improving the Compatibility of Diketopyrrolopyrrole Semiconducting Polymers for Biological Interfacing by Lysine Attachment

Weiyuan Du, David Ohayon, Craig Combe, Lorene Mottier, Iuliana P. Maria, Raja S. Ashraf, Hubert Fiumelli, Sahika Inal, Iain McCulloch

Chemistry of Materials· Volume 30· Issue 17
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Source abstract

Abstract

Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged, and low-surface energy semiconducting thin films limits their use as part of in vitro, cell-integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole semiconducting polymer on neural cell adhesion and growth and evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need for biological coating steps while changing the surface physiochemistry, which makes them promising for applications in bioelectronics.
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Research context

PolymersElectronic materials

OpenAlex topics: Conducting polymers and applications · Neuroscience and Neural Engineering · Organic Electronics and Photovoltaics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Physical Sciences and Engineering Division, KAUST Solar Center (KSC), King Abdullah University of Science and Technology (KAUST), KSC Thuwal 23955-6900, Saudi Arabia

Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia

Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom

Funding

Engineering and Physical Sciences Research Council · FP7 Ideas: European Research Council · Office of Sponsored Research, King Abdullah University of Science and Technology

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