Influences of mechanical barrier permeability on guided bone augmentation in the rat calvarium
Source abstract
Abstract
We used radiological and histological analyses to evaluate the effects of mechanical barrier permeability in a rat model of calvarial guided bone augmentation (GBA). The calvaria of 20 rats were exposed, and one of four types of plastic caps (an occlusive cylindrical plastic cap; a plastic cap with no top; a plastic cap with three holes; and a plastic cap with four holes) was randomly placed on both sides. Newly generated bone in the plastic caps was evaluated with micro-computed tomography (micro-CT) and histological analysis. Micro-CT volumetric analysis and decalcified hematoxylin and eosin-stained sections showed that GBA barrier permeability was inversely associated with the quantity of augmented bone obtained. Masson's trichrome staining showed that collagen in newly generated bony tissue was more mature in plastic caps with three holes than in those with more-permeable or more-occlusive barriers. Bone augmentation was inhibited in specimens exhibiting invasion of soft tissue through penetrating holes, and barrier permeability was associated with the quantity of augmented bone developed. In conclusion, moderate barrier permeability is optimal for development of mature augmented bone.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Orthopaedic implants and arthroplasty · Bone Tissue Engineering Materials · Bone health and osteoporosis research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry
Department of Periodontology, Nihon University School of Dentistry
Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry
Funding
Japan Society for the Promotion of Science
References (16)
Show source-provided references
1. 1. Spicer PP, Kretlow JD, Young S, Jansen JA, Kasper FK, Mikos AG (2012) Evaluation of bone regeneration using the rat critical size calvarial defect. Nat Protoc 7, 1918-1929.10.1038/nprot.2012.113 ↗
2. 2. Vajgel A, Mardas N, Farias BC, Petrie A, Cimões R, Donos N (2014) A systematic review on the critical size defect model. Clin Oral Implants Res 25, 879-893.10.1111/clr.12194 ↗
3. 3. Kochi G, Sato S, Fukuyama T, Morita C, Honda K, Arai Y et al. (2009) Analysis on the guided bone augmentation in the rat calvarium using a microfocus computerized tomography analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107, e42-48.10.1016/j.tripleo.2009.02.010 ↗
4. 4. Tsuchiya N, Sato S, Kigami R, Kawano E, Takane M, Arai Y et al. (2014) Effect of a chitosan sponge impregnated with platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria. J Oral Sci 56, 23-28.10.2334/josnusd.56.23 ↗
5. 5. Oginuma T, Sato S, Udagawa A, Saito Y, Arai Y, Ito K (2012) Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap. Oral Surg Oral Med Oral Pathol Oral Radiol 114, S107-113.10.1016/j.oooo.2011.08.004 ↗
6. 6. Tsunori K, Sato S, Hasuike A, Manaka S, Shino H, Sato N et al. (2015) Effects of intermittent administration of parathyroid hormone on bone augmentation in rat calvarium. Implant Dent 24, 142-148.10.1097/ID.0000000000000228 ↗
7. 7. Dahlin C, Linde A, Gottlow J, Nyman S (1988) Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 81, 672-676.10.1097/00006534-198805000-00004 ↗
8. 8. Roccuzzo M, Ramieri G, Bunino M, Berrone S (2007) Autogenous bone graft alone or associated with titanium mesh for vertical alveolar ridge augmentation: a controlled clinical trial. Clin Oral Implants Res 18, 286-294.10.1111/j.1600-0501.2006.01301.x ↗
9. 9. Aziz Aly LA, El-Menoufy H, Hassan A, Ragae A, Atta HM, Roshdy NK et al. (2011) Influence of autologous adipose derived stem cells and PRP on regeneration of dehiscence-type defects in alveolar bone: a comparative histochemical and histomorphometric study in dogs. Int J Stem Cells 4, 61-69.10.15283/ijsc.2011.4.1.61 ↗
10. 10. Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K (2014) Microcomputed tomographic and histomorphometric analyses of novel titanium mesh membranes for guided bone regeneration: a study in rat calvarial defects. Int J Oral Maxillofac Implants 29, 826-835.10.11607/jomi.3219 ↗
11. 11. Yamada Y, Sato S, Yagi H, Ujiie H, Ezawa S, Ito K (2012) Correlation in the densities of augmented and existing bone in guided bone augmentation. Clin Oral Implants Res 23, 837-845.10.1111/j.1600-0501.2011.02204.x ↗
12. 12. Udagawa A, Sato S, Hasuike A, Kishida M, Arai Y, Ito K (2013) Micro-CT observation of angiogenesis in bone regeneration. Clin Oral Implants Res 24, 787-792.10.1111/j.1600-0501.2012.02458.x ↗
13. 13. Usami K, Mizuno H, Okada K, Narita Y, Aoki M, Kondo T et al. (2009) Composite implantation of mesenchymal stem cells with endothelial progenitor cells enhances tissue-engineered bone formation. J Biomed Mater Res A 90, 730-741.10.1002/jbm.a.32142 ↗
14. 14. Osugi M, Katagiri W, Yoshimi R, Inukai T, Hibi H, Ueda M (2012) Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects. Tissue Eng Part A 18, 1479-1489.10.1089/ten.tea.2011.0325 ↗
15. 15. Akita D, Kano K, Saito-Tamura Y, Mashimo T, Sato-Shionome M, Tsurumachi N et al. (2016) Use of rat mature adipocyte-derived dedifferentiated fat cells as a cell source for periodontal tissue regeneration. Front Physiol 7, 50.10.3389/fphys.2016.00050 ↗
16. 16. Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M (2013) Effects of the permeability of shields with autologous bone grafts on bone augmentation. Int J Oral Maxillofac Implants 28, e386-392.10.11607/jomi.te19 ↗