Fabrication of a nonenzymatic cholesterol biosensor using carbon nanotubes from coconut oil
Source abstract
Abstract
A nonenzymatic cholesterol biosensor was fabricated at the surface of carbon nanotube electrode (CCNT), obtained from coconut oil. The voltammetric behavior of cholesterol at CCNT electrode was investigated by cyclic voltammetry and differential pulse voltammetry in the presence of 0.001 M H 2 SO 4 as electrolyte . The influence of the experimental parameters on the peak currents of cholesterol like pH, accumulation time, and scan rates were optimized. Under optimum conditions, the peak current was found to be linear in the cholesterol concentration range from 1 to 50 μM with a sensitivity of ~15.31 ± 0.01 μA μM −1 cm −2 and response time of about 6 s. Some characteristic studies of the nonenzymatic biosensor, such as reproducibility, substrate specificity, and storage stability have also been studied.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Electrochemical Analysis and Applications · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Norouzi, P., Faridbod, F., Nasli-Esfahani, E., Larijani, B., Ganjali, M.R.: Cholesterol biosensor based on MWCNTs–MnO2 nanoparticles using FFT continuous cyclic voltammetry. Int. J. Electrochem. Sci. 5, 1008–1017 (2010)10.1016/S1452-3981(23)15339-9 ↗
2. Aravamudhan, S., Ramgir, N.S., Bhansali, S.: Electrochemical biosensor for targeted detection in blood using aligned Au nanowires. Sens. Actuat. B 127, 29–35 (2007)10.1016/j.snb.2007.07.008 ↗
3. Arya, S.K., Solanki, P.R., Singh, S.P., Kaneto, K., Pandey, M.K., Datta, M., Malhotra, B.D.: Poly-(3-hexylthiophene) self-assembled monolayer based cholesterol biosensor using surface plasmon resonance technique. Biosens. Bioelectron. 22, 2516–2524 (2007)10.1016/j.bios.2006.10.011 ↗
4. Solanki, P.R., Kaushik, A., Agrawal, V.V., Malhotra, B.D.: Nanostructured metal oxide-based biosensors. NPG Asia Mater. 3, 17–24 (2011)10.1038/asiamat.2010.137 ↗
5. Manjunatha, R., Nagaraju, D.H., Suresh, G.S., Melo, J.S., Souza, S.F.D., Venkatesha, T.V.: Direct electrochemistry of cholesterol oxidase on MWCNTs. J. Electroanal. Chem. 651, 24–29 (2011)10.1016/j.jelechem.2010.11.009 ↗
6. Norouzi, P.: Application of coulometric FFT cyclic voltammetry for determination of cholesterol based on cholesterol oxidase nano-biosensor. Anal. Bioanal. Electrochem. 4(1), 70–82 (2010)
7. Sejin, P., Hankil, B., Taek, D.C.: Electrochemical non-enzymatic glucose sensors, review. Anal. Chim. Acta. 556, 46–57 (2006)10.1016/j.aca.2005.05.080 ↗
8. Yang, J., Lee, H., Cho, M., Nam, J., Lee, Y.: Non enzymatic cholesterol sensor based on spontaneous deposition of platinum nanoparticles on layer-by-layer assembled CNT thin film. Sens. Actuat. B Chem. 171, 374–379 (2012)10.1016/j.snb.2012.04.070 ↗
9. Solanki, P.R., Kaushik, A., Ansari, A.A., Tiwari, A., Malhotra, B.D.: Multi-walled carbon nanotubes/sol–gel-derived silica/chitosan nanobiocomposite for total cholesterol sensor. Sens. Actuat. B 137, 727–735 (2009)10.1016/j.snb.2008.12.044 ↗
10. Yang, J.Y., Li, Y., Chen, S.M., Kuo, C.L.: Fabrication of a cholesterol biosensor based on cholesterol oxidase and multiwall carbon nanotube hybrid composites. Int. J. Electrochem. Sci. 6, 2223–2234 (2011)10.1016/S1452-3981(23)18179-X ↗
11. Guo, M., Chen, J., Li, J., Lihua, N., Shouzhuo, Y.: Carbon nanotubes-based amperometric cholesterol biosensor fabricated through layer-by-layer technique. Electroanalysis 16, 1992–1998 (2004)10.1002/elan.200403053 ↗
12. Li, G., Liao, J.M., Hu, G.Q., Ma, N.Z., Wu, P.J.: Study of carbon nanotube modified biosensor for monitoring total cholesterol in blood. Biosens. Bioelectron. 20, 2140–2144 (2005)10.1016/j.bios.2004.09.005 ↗
13. Tan, X., Li, M., Cai, P., Lijun, L., Xiaoyong, Z.: An amperometric cholesterol biosensor based on multiwalled carbon nanotubes and organically modified sol–gel/chitosan hybrid composite film. Anal. Biochem. 337, 111–120 (2005)10.1016/j.ab.2004.10.040 ↗
14. Soylemez, S., Fulya, E.K., Ayda, G.N., Hava, A., Levent, T.: A novel conducting copolymer: investigation of its matrix properties for cholesterol biosensor applications. Sens. Actuat. B Chem. 182, 322–329 (2013)10.1016/j.snb.2013.03.009 ↗
15. Sunil, K.A., Monika, D., Bansi, D.M.: Recent advances in cholesterol biosensor. Biosens. Bioelectron. 23, 1083–1100 (2008)10.1016/j.bios.2007.10.018 ↗
16. Soylemeza, S., Fulya, E.K., Simge, T., Yasemin, A.U., Levent, T.: A sepiolite modified conducting polymer based biosensor. Colloids Surf. B 112, 549–555 (2013)10.1016/j.colsurfb.2013.07.013 ↗
17. Soylemez, S., Fulya, E.K., Merve, I., Serife, O.H., Levent, T.: Development of a novel biosensor based on a conducting polymer. Talanta 118, 84–89 (2014)10.1016/j.talanta.2013.10.007 ↗
18. Mitali, S., Soma, D.: Electrochemical studies of carbon nanotube obtained from coconut oil as non enzymatic glucose biosensor. Adv. Sci. Eng. Med. 5, 645–648 (2013)10.1166/asem.2013.1349 ↗
19. Soma, D., Mitali, S.: Non enzymatic electrochemical detection of glucose at rice starch-nanoparticles modified electrode. Int. J. Pharm. Bio. Sci. 4, 967–975 (2013)
20. Soma, D., Mitali, S.: Preparation of carbon nanosphere from bamboo and its use in water purification. Curr. Trends Tech. Sci. 2, 174–177 (2013)
21. Sumit, K.S., Manav, S., Mitali, S., Sabyasachi, S.: Carbon nanocubes and nanobricks from pyrolysis of rice. J. Nanosc. Nanotech. 10, 1–4 (2010)10.1166/jnn.2010.1484 ↗
22. Monica, D., Soma, D., Mitali, S.: Effect of reducing agents on the structure of zinc oxide under microwave irradiation. Adv. Manuf. 1, 183–186 (2013)10.1007/s40436-013-0020-7 ↗
23. Heines, V.: Peter Griess discoverer of diazo compounds. J. Chem. Educ. 35, 187–191 (1958)10.1021/ed035p187 ↗
24. Bard, A.J., Faulkner, L.R.: Electrochemical Methods—Fundamentals and Applications. Wiley, New York (2000)
25. Thomas, E.H., Harry, L.P.: Kinetics of the cholesterol-sulfuric acid reaction: a fast kinetic method for serum cholesterol. Clin. Chem. 19(10), 1128–1134 (1973)10.1093/clinchem/19.10.1128 ↗
26. Jr Gosser, D.K.: Cyclic Voltammetry: Simulation and Analysis of Reaction Mechanisms. Wiley-VCH, NewYork (1993)
27. Lin, Y., Lu, F., Tu, Y., Ren, Z.: Glucose biosensors based on carbon nanotube nanoelectrode ensembles. Nano. Lett. 4, 191–195 (2004)10.1021/nl0347233 ↗
28. Wang, H., Zhou, C., Liang, J., Yu, H., Peng, F., Yang, J.: High sensitivity glucose biosensor based on pt electrode position onto low-density aligned carbon nanotubes. Int. J. Electrochem. Sci. 3, 1258–1267 (2008)10.1016/S1452-3981(23)15521-0 ↗
29. Dar, G.N., Umar, A., Zaidi, S.A., Ibrahim, A.A., Abaker, M., Baskoutas, S., Al-Assir, M.S.: Ce doped ZnO nanorods for the detection of hazardous chemical. Sens. Actuat. B Chem. 173, 72–75 (2012)10.1016/j.snb.2012.06.001 ↗
30. Swartz, E., Krull, I.S.: Analytical method development and validation. Marcel Dekkar, New York (1997)