Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions
Source abstract
Abstract
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, widely used to diagnose and treat cancer. Evidence suggested that metal NPs can modulate the expression of various intracellular and extra-cellular signaling molecules in the tumor microenvironment. Metal nanoparticles possess anti-cancer activities via apoptosis and cell cycle arrest. In addition, metal NPs inhibit tumor angiogenesis, metastasis and inflammation to stop cancer proliferation. Synergistic applications of metal NPs with existing anti-cancer agents showed improvement in their bioactivity and bioavailability. This review explores the synthetic approaches, pharmacokinetics, and the cellular and molecular interactions of metal NPs in cancer.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoparticles: synthesis and applications · Cancer Research and Treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., Parkin, D.M.: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer. 127, 2893–2917 (2010)10.1002/ijc.25516 ↗
2. Kashyap, D., Garg, V.K., Sandberg, E.N., Goel, N., Bishayee, A.: Oncogenic and tumor suppressive components of the cell cycle in breast cancer progression and prognosis. Pharmaceutics 13, 1–28 (2021)10.3390/pharmaceutics13040569 ↗
3. Kashyap, D., Garg, V.K., Tuli, H.S., Yerer, M.B., Sak, K., Sharma, A.K., Kumar, M., Aggarwal, V., Sandhu, S.S.: Fisetin and quercetin: promising flavonoids with chemopreventive potential. Biomolecules 9, 1–22 (2019)10.3390/biom9050174 ↗
4. Ferlay, J., Colombet, M., Soerjomataram, I., Parkin, D.M., Piñeros, M., Znaor, A., Bray, F.: Cancer statistics for the year 2020: an overview. Int. J. Cancer. 149, 778–789 (2021)10.1002/ijc.33588 ↗
5. Kashyap, D., Sharma, A., Tuli, H.S., Sak, K., Garg, V.K., Buttar, H.S., Setzer, W.N., Sethi, G.: Apigenin: a natural bioactive flavone-type molecule with promising therapeutic function (2018)10.1016/j.jff.2018.07.037 ↗
6. Yadav, P., Jaswal, V., Sharma, A., Kashyap, D., Tuli, H.S., Garg, V.K., Das, S.K., Srinivas, R.: Celastrol as a pentacyclic triterpenoid with chemopreventive properties, https://pubmed.ncbi.nlm.nih.gov/29882724/ (2018)10.4155/ppa-2017-0035 ↗
7. Kashyap, D., Tuli, H.S., Sak, K., Garg, V.K., Goel, N., Punia, S.: Role of reactive oxygen species in cancer progression. Curr. Pharmacol. Rep. 5, 79–86 (2019)10.1007/s40495-019-00171-y ↗
8. Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., Bray, F.: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. Cancer J. Clin. 71, 209–249 (2021)10.3322/caac.21660 ↗
9. Kashyap, D., Garg, V.K., Goel, N.: Intrinsic and extrinsic pathways of apoptosis: role in cancer development and prognosis. Elsevier Inc. (2021)10.1016/bs.apcsb.2021.01.003 ↗
10. Kashyap, D., Tuli, H.S., Yerer, M.B., Sharma, A., Sak, K., Srivastava, S., Pandey, A., Garg, V.K., Sethi, G., Bishayee, A.: Natural product-based nanoformulations for cancer therapy: opportunities and challenges. Semin. Cancer Biol. 69, 5–23 (2021)10.1016/j.semcancer.2019.08.014 ↗
11. Kashyap, D., Sharma, A., Garg, V., Tuli, H.S., Kumar, G., Kumar, M.: Reactive oxygen species (ROS ): an activator of apoptosis and autophagy in cancer. J. Biol. Chem. Sci. 3, 256–264 (2016)
12. Kashyap, D., Tuli, H.S., Garg, V.K., Bhatnagar, S., Sharma, A.K.: Ursolic acid and quercetin: promising anticancer phytochemicals with antimetastatic and antiangiogenic potential. 1–7 (2017).10.4103/tme.tme_3_17 ↗
13. Manu, K.A., Shanmugam, M.K., Li, F., Chen, L., Siveen, K.S., Ahn, K.S., Kumar, A.P., Sethi, G.: Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. J. Mol. Med. 92, 267–276 (2014)10.1007/s00109-013-1095-0 ↗
14. Kirtonia, A., Gala, K., Fernandes, S.G., Pandya, G., Pandey, A.K., Sethi, G., Khattar, E., Garg, M.: Repurposing of drugs: an attractive pharmacological strategy for cancer therapeutics. Semin. Cancer Biol. 68, 258–278 (2021)10.1016/j.semcancer.2020.04.006 ↗
15. Valladares, B.T., Crespo, P.C., Herranz, U.A., Caamaño, A.G.: Adjuvant treatment in lung cancer. J. Clin. Transl. Res. 7, 2 (2021)
16. Román-Jobacho, A., Hernández-Miguel, M., García-Anaya, M.J., Gómez-Millán, J., Medina-Carmona, J.A., Otero-Romero, A.: Oligometastatic non-small cell lung cancer: current management. J. Clin. Transl. Res. 7(3), 311 (2021)
17. Luna, J., Sotoca, A., Fernández, P., Miralles, C., Rodríguez, A.: Recent advances in early stage lung cancer. J. Clin. Transl. Res. 7(2), 163 (2021)
18. Lu, X., Shi, H., Que, Q., Qiu, S.: Research progress in immunotherapy of advanced non-small cell lung cancer. Trends Immunother. 5, 58–64 (2021)10.24294/ti.v5.i2.1.1367 ↗
19. Guo, X., Hu, H., Jin, Q., Li, H., Cheng, Q.: Studies on the proliferation inhibition effects of tua from Actinidia chinensis radix on lung cancer xenografts in nude mice and its preliminary mechanism. Trends Immunother. 5, 14–23 (2021)10.24294/ti.v5.i2.1.1371 ↗
20. Conde, J., Doria, G., Baptista, P.: Noble metal nanoparticles applications in cancer. J. Drug Deliv. 2012, 1–12 (2012)10.1155/2012/751075 ↗
21. Tuli, H.S., Sak, K., Gupta, D.S., Kaur, G., Aggarwal, D., Chaturvedi Parashar, N., Choudhary, R., Yerer, M.B., Kaur, J., Kumar, M., Garg, V.K., Sethi, G.: Anti-inflammatory and anticancer properties of birch bark-derived betulin: recent developments. Plants. 10, 2663 (2021)10.3390/plants10122663 ↗
22. Tuli, H.S., Mistry, H., Kaur, G., Aggarwal, D., Garg, V.K., Mittal, S., Yerer, M.B., Sak, K., Khan, M.A.: Gallic acid: a dietary polyphenol that exhibits anti-neoplastic activities by modulating multiple oncogenic targets. Anticancer. Agents Med. Chem. 22, 499–514 (2021)10.2174/1871520621666211119085834 ↗
23. Singh, A., Goel, N.: Yogita: integrative analysis of multi-genomic data for kidney renal cell carcinoma. Interdiscip. Sci. Comput. Life Sci. 12, 12–23 (2020)10.1007/s12539-019-00345-8 ↗
24. Zhang, J., Ahn, K.S., Kim, C., Shanmugam, M.K., Siveen, K.S., Arfuso, F., Samym, R.P., Deivasigamanim, A., Lim, L.H.K., Wang, L., Goh, B.C., Kumar, A.P., Hui, K.M., Sethi, G.: Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model. Antioxid Redox Signal. 24, 575–589 (2016)10.1089/ars.2015.6418 ↗
25. Kwang, S.A., Sethi, G., Chaturvedi, M.M., Aggarwal, B.B.: Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway. Int. J. Cancer. 123, 1733–1740 (2008)10.1002/ijc.23745 ↗
26. Rai, M., Ingle, A.P., Birla, S., Yadav, A., Santos, C.A.D.: Strategic role of selected noble metal nanoparticles in medicine. Crit. Rev. Microbiol. 42, 696–719 (2016)
27. Nasery, M.M., Abadi, B., Poormoghadam, D., Zarrabi, A., Keyhanvar, P., Khanbabaei, H., Ashrafizadeh, M., Mohammadinejad, R., Tavakol, S., Sethi, G.: Curcumin delivery mediated by bio-based nanoparticles: a review. Molecules 25, 689 (2020)10.3390/molecules25030689 ↗
28. Yan, J., Yao, Y., Yan, S., Gao, R., Lu, W., He, W.: Chiral protein supraparticles for tumor suppression and synergistic immunotherapy: an enabling strategy for bioactive supramolecular chirality construction. Nano Lett. 20, 5844–5852 (2020)10.1021/acs.nanolett.0c01757 ↗
29. Guo, S., Li, C., Zhang, Y., Wang, Y., Li, B., Yang, M., Zhang, X., Liu, G.: Experimental evaluation of the lubrication performance of mixtures of castor oil with other vegetable oils in MQL grinding of nickel-based alloy. J. Clean. Prod. 140, 1060–1076 (2017)10.1016/j.jclepro.2016.10.073 ↗
30. Zhang, J., Li, C., Zhang, Y., Yang, M., Jia, D., Liu, G., Hou, Y., Li, R., Zhang, N., Wu, Q., Cao, H.: Experimental assessment of an environmentally friendly grinding process using nanofluid minimum quantity lubrication with cryogenic air. J. Clean. Prod. 193, 236–248 (2018)10.1016/j.jclepro.2018.05.009 ↗
31. Kuchur, O.A., Tsymbal, S.A., Shestovskaya, M.V., Serov, N.S., Dukhinova, M.S., Shtil, A.A.: Metal-derived nanoparticles in tumor theranostics: potential and limitations. J. Inorg. Biochem. 209, 111117 (2020)10.1016/j.jinorgbio.2020.111117 ↗
32. Li, J., Ren, H., Zhang, Y.: Metal-based nano-vaccines for cancer immunotherapy. Coord. Chem. Rev. 455, 214345 (2022)10.1016/j.ccr.2021.214345 ↗
33. Zou, Q., Xing, P., Wei, L., Liu, B.: Gene2vec: gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA. RNA 25, 205–218 (2019)10.1261/rna.069112.118 ↗
34. Zhao, R., Xiang, J., Wang, B., Chen, L., Tan, S.: Recent advances in the development of noble metal NPs for cancer therapy. Bioinorg. Chem. Appl. 2022, 2444516 (2022)10.1155/2022/2444516 ↗
35. Shariatzadeh, S., Moghimi, N., Khalafi, F., Shafiee, S., Mehrabi, M., Ilkhani, S., Tosan, F., Nakhaei, P., Alizadeh, A., Varma, R.S., Taheri, M.: Metallic nanoparticles for the modulation of tumor microenvironment: a new horizon. Front. Bioeng. Biotechnol. 10, 1867 (2022)10.3389/fbioe.2022.847433 ↗
36. Subhan, M.A., Muzibur Rahman, M.: Recent development in metallic nanoparticles for breast cancer therapy and diagnosis. Chem. Rec. (2022). https://doi.org/10.1002/tcr.20210033110.1002/tcr.202100331 ↗
37. Khursheed, R., Dua, K., Vishwas, S., Gulati, M., Jha, N.K., Aldhafeeri, G.M., Alanazi, F.G., Goh, B.H., Gupta, G., Paudel, K.R., Hansbro, P.M., Chellappan, D.K., Singh, S.K.: Biomedical applications of metallic nanoparticles in cancer: current status and future perspectives. Biomed. Pharmacother. 150, 112951 (2022)10.1016/j.biopha.2022.112951 ↗
38. Xu, J.J., Zhang, W.C., Guo, Y.W., Chen, X.Y., Zhang, Y.N.: Metal nanoparticles as a promising technology in targeted cancer treatment. Drug Deliv. 29, 664–678 (2022)10.1080/10717544.2022.2039804 ↗
39. Evans, E.R., Bugga, P., Asthana, V., Drezek, R.: Metallic nanoparticles for cancer immunotherapy. Mater. Today. 21, 673–685 (2018)10.1016/j.mattod.2017.11.022 ↗
40. Tinajero-Díaz, E., Salado-Leza, D., Gonzalez, C., Velázquez, M.M., López, Z., Bravo-Madrigal, J., Knauth, P., Flores-Hernández, F.Y., Herrera-Rodríguez, S.E., Navarro, R.E., Cabrera-Wrooman, A., Krötzsch, E., Carvajal, Z.Y.G., Hernández-Gutiérrez, R.: Green metallic nanoparticles for cancer therapy: evaluation models and cancer applications. Pharmaceutics. 13, 1719 (2021)10.3390/pharmaceutics13101719 ↗
41. Desoize, B.: Metals and metal compounds in cancer treatment. Anticancer Res. 24, 1529–1544 (2004)
42. Chen, X., Li, X., Xie, J., Yang, H., Liu, A.: Non-invasive discrimination of multiple myeloma using label-free serum surface-enhanced Raman scattering spectroscopy in combination with multivariate analysis. Anal. Chim. Acta. 1191, 339296 (2022)10.1016/j.aca.2021.339296 ↗
43. Păduraru, D.N., Ion, D., Niculescu, A.G., Mușat, F., Andronic, O., Grumezescu, A.M., Bolocan, A.: Recent developments in metallic nanomaterials for cancer therapy. Diagnosing and imaging applications. Pharmaceutics. 14, 435 (2022)10.3390/pharmaceutics14020435 ↗
44. Niculescu, A.-G., Grumezescu, A.M.: Novel tumor-targeting nanoparticles for cancer treatment—a review. Int. J. Mol. Sci. 23, 5253 (2022)10.3390/ijms23095253 ↗
45. Baig, N., Kammakakam, I., Falath, W., Kammakakam, I.: Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges. Mater. Adv. 2, 1821–1871 (2021)10.1039/D0MA00807A ↗
46. Prabakaran, S., Rajan, M.: Biosynthesis of nanoparticles and their roles in numerous areas. In: Comprehensive Analytical Chemistry. pp. 1–47. Elsevier (2021)10.1016/bs.coac.2021.02.001 ↗
47. Yilmaz, E., Soylak, M.: Functionalized nanomaterials for sample preparation methods. In: Handbook of Nanomaterials in Analytical Chemistry: Modern Trends in Analysis. pp. 375–413. Elsevier (2019)10.1016/B978-0-12-816699-4.00015-3 ↗
48. Chen, L., Huang, Y., Yu, X., Lu, J., Jia, W., Song, J., Liu, L., Wang, Y., Huang, Y., Xie, J., Li, M.: Corynoxine protects dopaminergic neurons through inducing autophagy and diminishing neuroinflammation in rotenone-induced animal models of Parkinson’s disease. Front. Pharmacol. (2021). https://doi.org/10.3389/fphar.2021.64290010.3389/fphar.2021.642900 ↗
49. Jin, K., Yan, Y., Chen, M., Wang, J., Pan, X., Liu, X., Liu, M., Lou, L., Wang, Y., Ye, J.: Multimodal deep learning with feature level fusion for identification of choroidal neovascularization activity in age-related macular degeneration. Acta Ophthalmol. 100, e512–e520 (2022)10.1111/aos.14928 ↗
50. Sun, L., Yuan, G., Gao, L., Yang, J., Chhowalla, M., Gharahcheshmeh, M.H., Gleason, K.K., Choi, Y.S., Hong, B.H., Liu, Z.: Chemical vapour deposition. Nat. Rev. Methods Prim. 11(1), 1–20 (2021)
51. Raizada, P., Sudhaik, A., Patial, S., Hasija, V., Parwaz Khan, A.A., Singh, P., Gautam, S., Kaur, M., Nguyen, V.H.: Engineering nanostructures of CuO-based photocatalysts for water treatment: current progress and future challenges. Arab. J. Chem. 13, 8424–8457 (2020)10.1016/j.arabjc.2020.06.031 ↗
52. El-Deeb, N.M., Abo-Eleneen, M.A., Awad, O.A., Abo-Shady, A.M.: Arthrospira platensis-mediated green biosynthesis of silver nano-particles as breast cancer controlling agent. in vitro and in vivo safety approaches. Appl. Biochem. Biotechnol. 194, 2183–2203 (2022)10.1007/s12010-021-03751-1 ↗
53. Ko, W.C., Wang, S.J., Hsiao, C.Y., Hung, C.T., Hsu, Y.J., Chang, D.C., Hung, C.F.: Pharmacological role of functionalized gold nanoparticles in disease applications. Molecules 27, 1551 (2022)10.3390/molecules27051551 ↗
54. Gao, T., Zhang, Y., Li, C., Wang, Y., An, Q., Liu, B., Said, Z., Sharma, S.: Grindability of carbon fiber reinforced polymer using CNT biological lubricant. Sci. Rep. 11, 1–14 (2021)10.1038/s41598-021-02071-y ↗
55. Li, B., Li, C., Zhang, Y., Wang, Y., Jia, D., Yang, M.: Grinding temperature and energy ratio coefficient in MQL grinding of high-temperature nickel-base alloy by using different vegetable oils as base oil. Chin. J. Aeronaut. 29, 1084–1095 (2016)10.1016/j.cja.2015.10.012 ↗
56. Dhand, C., Dwivedi, N., Loh, X.J., Jie Ying, A.N., Verma, N.K., Beuerman, R.W., Lakshminarayanan, R., Ramakrishna, S.: Methods and strategies for the synthesis of diverse nanoparticles and their applications: a comprehensive overview. RSC Adv. 5, 105003–105037 (2015)10.1039/C5RA19388E ↗
57. Liu, M., Li, C., Zhang, Y., An, Q., Yang, M., Gao, T., Mao, C., Liu, B., Cao, H., Xu, X., Said, Z.: Cryogenic minimum quantity lubrication machining: from mechanism to application. Front. Mech. Eng. 16(4), 649–697 (2021)10.1007/s11465-021-0654-2 ↗
58. Xin, C.U., Changhe, L.I., Wenfeng, D.I., Yun, C.H., Cong, M.A., Xuefeng, X.U., Bo, L.I., Dazhong, W.A., Li, H.N., Zhang, Y., Zafar, S.A.: Minimum quantity lubrication machining of aeronautical materials using carbon group nanolubricant: from mechanisms to application. Chin. J. Aeronaut. (2021). https://doi.org/10.1016/j.cja.2021.08.01110.1016/j.cja.2021.08.011 ↗
59. Vaseghi, Z., Nematollahzadeh, A., Tavakoli, O.: Green methods for the synthesis of metal nanoparticles using biogenic reducing agents: a review. Rev. Chem. Eng. 34, 529–559 (2018)10.1515/revce-2017-0005 ↗
60. Abid, N., Khan, A.M., Shujait, S., Chaudhary, K., Ikram, M., Imran, M., Haider, J., Khan, M., Khan, Q., Maqbool, M.: Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: a review. Adv. Coll. Interface Sci. 300, 102597 (2022)10.1016/j.cis.2021.102597 ↗
61. Almeida, J.C., Davim, E.J.C., Salvado, I.M.M., Fernandes, M.H.V., Costa, F.M., Rey-García, F., Francisco, L.M., Lopes, A.B.: Red ruby glass from gold nanoparticles obtained by LASiS—a new approach. J. Non. Cryst. Solids. 537, 119987 (2020)10.1016/j.jnoncrysol.2020.119987 ↗
62. Yang, L., Wang, Z., Ma, L., Li, A., Xin, J., Wei, R., Lin, H., Wang, R., Chen, Z., Gao, J.: The roles of morphology on the relaxation rates of magnetic nanoparticles. ACS Nano 12, 4605–4614 (2018)10.1021/acsnano.8b01048 ↗
63. Liu, L., Corma, A.: Metal catalysts for heterogeneous catalysis: from single atoms to nanoclusters and nanoparticles. Chem. Rev. 118, 4981–5079 (2018)10.1021/acs.chemrev.7b00776 ↗
64. Astruc, D.: Introduction: nanoparticles in catalysis. Chem. Rev. 120, 461–463 (2020)10.1021/acs.chemrev.8b00696 ↗
65. Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M.A., Alkawareek, M.Y., Dreaden, E.C., Brown, D., Alkilany, A.M., Farokhzad, O.C., Mahmoudi, M.: Cellular uptake of nanoparticles: journey inside the cell. Chem. Soc. Rev. 46, 4218–4244 (2017)10.1039/C6CS00636A ↗
66. Romberg, B., Hennink, W.E., Storm, G.: Sheddable coatings for long-circulating nanoparticles. Pharm. Res. 25, 55–71 (2008)10.1007/s11095-007-9348-7 ↗
67. Gwon, K., Park, J.D., Lee, S., Yu, J.S., Lee, D.N.: Biocompatible core–shell-structured Si-based NiO nanoflowers and their anticancer activity. Pharmaceutics. 14, 268 (2022)10.3390/pharmaceutics14020268 ↗
68. Lin, Z., Monteiro-Riviere, N.A., Riviere, J.E.: Pharmacokinetics of metallic nanoparticles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 7, 189–217 (2015)10.1002/wnan.1304 ↗
69. Park, K., Park, E.J., Chun, I.K., Choi, K., Lee, S.H., Yoon, J., Lee, B.C.: Bioavailability and toxicokinetics of citrate-coated silver nanoparticles in rats. Arch. Pharm. Res. 34, 153–158 (2011)10.1007/s12272-011-0118-z ↗
70. Mathur, P., Jha, S., Ramteke, S., Jain, N.K.: Pharmaceutical aspects of silver nanoparticles. Artif. Cells Nanomed. Biotechnol. 46, 115–126 (2018)10.1080/21691401.2017.1414825 ↗
71. Samberg, M.E., Oldenburg, S.J., Monteiro-Riviere, N.A.: Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ. Health Perspect. 118, 407–413 (2010)10.1289/ehp.0901398 ↗
72. Larese, F.F., D’Agostin, F., Crosera, M., Adami, G., Renzi, N., Bovenzi, M., Maina, G.: Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicology 255, 33–37 (2009)10.1016/j.tox.2008.09.025 ↗
73. Lankveld, D.P.K., Oomen, A.G., Krystek, P., Neigh, A., Troost-de Jong, A., Noorlander, C.W., Van Eijkeren, J.C.H., Geertsma, R.E., De Jong, W.H.: The kinetics of the tissue distribution of silver nanoparticles of different sizes. Biomaterials 31, 8350–8361 (2010)10.1016/j.biomaterials.2010.07.045 ↗
74. Dziendzikowska, K., Gromadzka-Ostrowska, J., Lankoff, A., Oczkowski, M., Krawczyńska, A., Chwastowska, J., Sadowska-Bratek, M., Chajduk, E., Wojewódzka, M., Dušinská, M., Kruszewski, M.: Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats. J. Appl. Toxicol. 32, 920–928 (2012)10.1002/jat.2758 ↗
75. Kim, Y.S., Kim, J.S., Cho, H.S., Rha, D.S., Kim, J.M., Park, J.D., Choi, B.S., Lim, R., Chang, H.K., Chung, Y.H., Kwon, I.H., Jeong, J., Han, B.S., Yu, I.J.: Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal. Toxicol. 20, 575–583 (2008)10.1080/08958370701874663 ↗
76. Loeschner, K., Hadrup, N., Qvortrup, K., Larsen, A., Gao, X., Vogel, U., Mortensen, A., Lam, H.R., Larsen, E.H.: Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate. Part. Fibre Toxicol. 8, 18 (2011)10.1186/1743-8977-8-18 ↗
77. Park, E.J., Bae, E., Yi, J., Kim, Y., Choi, K., Lee, S.H., Yoon, J., Lee, B.C., Park, K.: Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Environ. Toxicol. Pharmacol. 30, 162–168 (2010)10.1016/j.etap.2010.05.004 ↗
78. Kim, Y.S., Song, M.Y., Park, J.D., Song, K.S., Ryu, H.R., Chung, Y.H., Chang, H.K., Lee, J.H., Oh, K.H., Kelman, B.J., Hwang, I.K., Yu, I.J.: Subchronic oral toxicity of silver nanoparticles. Part. Fibre Toxicol. (2010). https://doi.org/10.1186/1743-8977-7-2010.1186/1743-8977-7-20 ↗
79. Tang, J., Xiong, L., Wang, S., Wang, J., Liu, L., Li, J., Wan, Z., Xi, T.: Influence of silver nanoparticles on neurons and blood-brain barrier via subcutaneous injection in rats. Appl. Surf. Sci. 255, 502–504 (2008)10.1016/j.apsusc.2008.06.058 ↗
80. Van Der Zande, M., Vandebriel, R.J., Van Doren, E., Kramer, E., Herrera Rivera, Z., Serrano-Rojero, C.S., Gremmer, E.R., Mast, J., Peters, R.J.B., Hollman, P.C.H., Hendriksen, P.J.M., Marvin, H.J.P., Peijnenburg, A.A.C.M., Bouwmeester, H.: Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano 6, 7427–7442 (2012)10.1021/nn302649p ↗
81. Kim, Y.S., Song, M.Y., Park, J.D., Song, K.S., Ryu, H.R., Chung, Y.H., Chang, H.K., Lee, J.H., Oh, K.H., Kelman, B.J., Hwang, I.K., Yu, I.J.: Subchronic oral toxicity of silver nanoparticles. Part. Fibre Toxicol. 7, 20 (2010)10.1186/1743-8977-7-20 ↗
82. Liu, J., Wang, Z., Liu, F.D., Kane, A.B., Hurt, R.H.: Chemical transformations of nanosilver in biological environments. ACS Nano 6, 9887–9899 (2012)10.1021/nn303449n ↗
83. Lee, Y., Kim, P., Yoon, J., Lee, B., Choi, K., Kil, K.H., Park, K.: Serum kinetics, distribution and excretion of silver in rabbits following 28 days after a single intravenous injection of silver nanoparticles. Nanotoxicology 7, 1120–1130 (2013)10.3109/17435390.2012.710660 ↗
84. Yang, M., Li, C., Zhang, Y., Jia, D., Li, R., Hou, Y., Cao, H., Wang, J.: Predictive model for minimum chip thickness and size effect in single diamond grain grinding of zirconia ceramics under different lubricating conditions. Ceram. Int. 45, 14908–14920 (2019)10.1016/j.ceramint.2019.04.226 ↗
85. Libutti, S.K., Paciotti, G.F., Byrnes, A.A., Alexander, H.R., Gannon, W.E., Walker, M., Seidel, G.D., Yuldasheva, N., Tamarkin, L.: Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clin. Cancer Res. 16, 6139–6149 (2010)10.1158/1078-0432.CCR-10-0978 ↗
86. NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery—Full Text View—ClinicalTrials.gov, https://clinicaltrials.gov/ct2/show/NCT03020017
87. ClinicalTrials.gov: National Library of Medicine (US): Pilot Study of AuroLase(tm) Therapy in Refractory and/or Recurrent Tumors of the Head and Neck - Full Text View - ClinicalTrials.gov, https://clinicaltrials.gov/ct2/show/NCT00848042
88. Magnetic Nanoparticle Thermoablation-Retention and Maintenance in the Prostate:A Phase 0 Study in Men - Full Text View - ClinicalTrials.gov, https://clinicaltrials.gov/ct2/show/NCT02033447.
89. Schleh, C., Semmler-Behnke, M., Lipka, J., Wenk, A., Hirn, S., Schäffler, M., Schmid, G., Simon, U., Kreyling, W.G.: Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration. Nanotoxicology 6, 36–46 (2012)10.3109/17435390.2011.552811 ↗
90. Janer, G., Mas del Molino, E., Fernández-Rosas, E., Fernández, A., Vázquez-Campos, S.: Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicol. Lett. 228, 103–110 (2014)10.1016/j.toxlet.2014.04.014 ↗
91. Cho, W.S., Cho, M., Jeong, J., Choi, M., Cho, H.Y., Han, B.S., Kim, S.H., Kim, H.O., Lim, Y.T., Chung, B.H., Jeong, J.: Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol. Appl. Pharmacol. 236, 16–24 (2009)10.1016/j.taap.2008.12.023 ↗
92. Sonavane, G., Tomoda, K., Sano, A., Ohshima, H., Terada, H., Makino, K.: In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size. Colloids Surfaces B Biointerfaces. 65, 1–10 (2008)10.1016/j.colsurfb.2008.02.013 ↗
93. De Jong, W.H., Hagens, W.I., Krystek, P., Burger, M.C., Sips, A.J.A.M., Geertsma, R.E.: Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29, 1912–1919 (2008)10.1016/j.biomaterials.2007.12.037 ↗
94. Takeda, K., Suzuki, K.I., Ishihara, A., Kubo-Irie, M., Fujimoto, R., Tabata, M., Oshio, S., Nihei, Y., Ihara, T., Sugamata, M.: Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J. Heal. Sci. 55, 95–102 (2009)10.1248/jhs.55.95 ↗
95. Bourrinet, P., Bengele, H.H., Bonnemain, B., Dencausse, A., Idee, J.M., Jacobs, P.M., Lewis, J.M.: Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest. Radiol. 41, 313–324 (2006)10.1097/01.rli.0000197669.80475.dd ↗
96. Liu, C., Ho, P.C.L., Wong, F.C., Sethi, G., Wang, L.Z., Goh, B.C.: Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects. Cancer Lett. 362, 8–14 (2015)10.1016/j.canlet.2015.03.019 ↗
97. Patel, S.M., Nagulapalli Venkata, K.C., Bhattacharyya, P., Sethi, G., Bishayee, A.: Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases. Semin. Cancer Biol. 40–41, 100–115 (2016)10.1016/j.semcancer.2016.03.002 ↗
98. Kirtonia, A., Sethi, G., Garg, M.: The multifaceted role of reactive oxygen species in tumorigenesis. Cell. Mol. Life Sci. 77, 4459–4483 (2020)10.1007/s00018-020-03536-5 ↗
99. Kim, C., Lee, S.G., Yang, W.M., Arfuso, F., Um, J.Y., Kumar, A.P., Bian, J., Sethi, G., Ahn, K.S.: Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model. Cancer Lett. 431, 123–141 (2018)10.1016/j.canlet.2018.05.038 ↗
100. Manu, K.A., Shanmugam, M.K., Ramachandran, L., Li, F., Fong, C.W., Kumar, A.P., Tan, P., Sethi, G.: First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clin. Cancer Res. 18, 2220–2229 (2012)10.1158/1078-0432.CCR-11-2470 ↗