Improvements in phase stability and densification of β-tricalcium phosphate bioceramics by strontium-containing phosphate-based glass additive
Source abstract
Abstract
Abstract β-tricalcium phosphate (β-TCP), which transforms to α-TCP at around 1125 °C, is characterized by poor sinterability. In this study, for the first time strontium-containing phosphate-based glass (SPG) was used as a sintering additive for β-TCP, which was sintered at 1250 °C. The results indicated that the SPG additive allowed for liquid-state sintering of β-TCP, thereby noticeably promoting the densification of β-TCP bioceramics. In the sintering process SPG reacted with β-TCP, and the metal ions from SPG were substituted for the calcium ions of β-TCP. The SPG additive effectively inhibited the phase transformation of β-TCP to α-TCP in the bioceramics. The compressive strength of porous β-TCP bioceramics was markedly increased by introducing 10 wt% SPG. The SPG is considered as an effective sintering additive to improve the phase stability and mechanical strength of porous β-TCP bioceramics.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · Facial Trauma and Fracture Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Calcium orthophosphate bioceramics10.1016/j.ceramint.2015.08.004 ↗
2. Bone formation and resorption of highly purified beta-tricalcium phosphate in the rat femoral condyle10.1016/j.biomaterials.2005.02.026 ↗
3. Porosity of 3D biomaterial scaffolds and osteogenesis10.1016/j.biomaterials.2005.02.002 ↗
4. The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3(PO4)2 composite bioceramics10.1016/j.actbio.2011.08.019 ↗
5. Elliot · 1994
6. An improvement in sintering property of β-tricalcium phosphate by addition of calcium pyrophosphate10.1016/S0142-9612(01)00201-0 ↗
7. Sinterability of β-orthophosphate powder prepared by spray pyrolysis10.1111/j.1151-2916.1994.tb05368.x ↗
8. Self-setting calcium orthophosphate formulations: cements, concretes, pastes and putties
9. Influence of Mg-doping, calcium pyrophosphate impurities and cooling rate on the allotropic α↔β-tricalcium phosphate phase transformations10.1016/j.jeurceramsoc.2015.09.037 ↗
10. The role of the chemical composition of monetite on the synthesis and properties of α-tricalcium phosphate10.1016/j.msec.2013.08.038 ↗
11. Effects of Sr2+/Zn2+ co-substitution on crystal structure and properties of nano-β-tricalcium phosphate10.1016/j.ceramint.2017.12.242 ↗
12. Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of beta-TCP ceramics10.1016/j.actbio.2010.05.012 ↗
13. Does the incorporation of zinc into calcium phosphate improve bone repair? A systematic review10.1016/j.ceramint.2017.10.157 ↗
14. Effect of MgO addition on solid state synthesis and thermal behavior of beta-tricalcium phosphate10.1016/j.ceramint.2014.10.073 ↗
15. Substitution model of monovalent (Li, Na, and K), divalent (Mg), and trivalent (Al) metal ions for β-tricalcium phosphate10.1111/j.1551-2916.2005.00727.x ↗
16. ZnO, SiO2, and SrO doping in resorbable tricalcium phosphates: influence on strength degradation, mechanical properties, and in vitro bone-cell material interactions10.1002/jbm.b.32789 ↗
17. Fabrication of β-TCP foam: effects of magnesium oxide as phase stabilizer on its properties10.1016/j.ceramint.2015.07.053 ↗
18. Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary based P2O5–CaO–Na2O glass system10.1016/S0142-9612(03)00546-5 ↗
19. Fabrication of β-tricalcium phosphate composite ceramic sphere-based scaffolds with hierarchical pore structure for bone regeneration10.1088/1758-5090/aa6a62 ↗
20. Preparation, mechanical property and cytocompatibility of freeze-cast porous calcium phosphate ceramics reinforced by phosphate-based glass10.1016/j.msec.2016.08.008 ↗
21. Low temperature fabrication of high strength porous calcium phosphate and the evaluation of the osteoconductivity10.1007/s10856-009-3764-7 ↗
22. Fabrication of a novel calcium carbonate composite ceramic as bone substitute10.1111/jace.13285 ↗
23. Effect of ternary phosphate-based glass compositions on osteoblast and osteoblast-like proliferation, differentiation and death in vitro10.1016/j.actbio.2006.11.008 ↗
24. Role of MgO on the HAp forming ability in phosphate based glasses10.1016/j.ceramint.2012.01.026 ↗
25. Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis10.1016/j.pharmthera.2012.07.009 ↗
26. Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics10.1016/j.biomaterials.2013.09.056 ↗
27. Strontium-containing apatite/poly lactide composites favoring osteogenic differentiation and in vivo bone formation10.1021/ab500005e ↗
28. Bio-inspired synthesis: understanding and exploitation of the crystallization process from amorphous precursors10.1039/C1NR11044F ↗
29. Synthesis, X-ray diffraction and solid-state 31P magic angle spinning NMR study of α-tricalcium orthophosphate10.1007/BF00122016 ↗
30. Structure and properties of strontium-doped phosphate-based glasses10.1098/rsif.2008.0348 ↗