A new insight into biomedical applications of an apatite like oxyphosphate – BiCa4(PO4)3O
Source abstract
Abstract
Divalent ion (Cu, Co, Mn, Mg and Zn) substituted BiCa4(PO4)3O (BCPO) – an apatite like oxyphosphate is synthesized by conventional high temperature solid state method and characterized by powder X-ray diffraction (XRD), Fourier Transform infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Scanning electron microscope (SEM) and Energy dispersive X-ray spectroscopy (EDAX). Antimicrobial properties of these synthesized materials are studied by spread plate method against the three organisms E.coli, S.aureus, and C.albicans. It is noticed from the results that Copper substitution improved the antibacterial activity of the oxyapatite compared to other divalent ion substitution. Cytotoxicity study is carried out by MTT assay method against fibroblast NIH 3T3 cell line. All the synthesized compounds are non-cytotoxic except Mn(II) and Zn(II) substituted oxyapatite.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Thermal and Kinetic Analysis · Chemical Synthesis and Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (36)
Show source-provided references
1. Antibacterial nanosized silver substituted hydroxyapatite: Synthesis and characterization10.1002/jbm.a.30958 ↗
2. Infection and sepsis after operations for total hip or knee-joint replacement: Influence of ultraclean air, prophylactic antibiotics and other factors10.1017/S0022172400065098 ↗
3. Prosthetic joint infection
4. Reducing implant-related infections: active release strategies10.1039/b515219b ↗
5. Antibacterial effects of Ag-HAp thin films on alumina substrates10.1016/S0040-6090(98)00956-0 ↗
6. Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review10.1016/j.injury.2006.04.016 ↗
7. Comparison of different lewis acid supported on hydroxyapatite as new catalysts of Friedel–crafts alkylation10.1016/S0926-860X(01)00599-3 ↗
8. Selective protein adsorption property and characterization of nano-crystalline zinc-containing hydroxyapatite10.1016/j.actbio.2005.09.002 ↗
9. Synthetic hydroxyapatites employed as inorganic cation-exchangers10.1039/f19817701059 ↗
10. Bioceramics: from concept to clinic10.1111/j.1151-2916.1991.tb07132.x ↗
11. Advances in bioceramics10.1111/j.1551-2916.1987.tb00047.x ↗
12. Chemical implant fixation using hydroxyl-apatite coatings. The development of a human total hip prosthesis for chemical fixation to bone using hydroxyl-apatite coatings on titanium substrates10.1097/00003086-198712000-00014 ↗
13. Shaoxian · Mater. Res. Soc. Symp. Proc · 1993 · 292 · 27110.1557/PROC-292-271 ↗
14. Influence of Sr2+ on strontium substituted hydroxyapatite׳s (Sr-HA) cytotoxicity
15. Understanding the impact of divalent cation substitution on hydroxyapatite: an in vitro multiparametric study on biocompatibility10.1002/jbm.a.33126 ↗
16. Bismuth-doped injectable calcium phosphate cement with improved radiopacity and potent antimicrobial activity for root canal filling10.1016/j.actbio.2010.02.049 ↗
17. Recent advances in bioinorganic chemistry of bismuth
18. Antimicrobial effects of metal ions (Ag+, Cu2+, Zn2+) in hydroxyapatite
19. Preparation and characterization of beta-tricalcium phosphate co-doped with monovalent and divalent antibacterial metal ions10.1016/j.actbio.2009.04.010 ↗
20. Effect of chemical treatments on the ionic conductivity of carbonate apatite10.1016/S1466-6049(01)00054-X ↗
21. Structural studies of apatite-type oxide ion conductors doped with cobalt10.1039/b418992b ↗
22. Synthesis and Eu3+ luminescence in new oxysilicates, ALa3Bi(SiO4)3O and ALa2Bi2(SiO4)3O [A= Ca, Sr and Ba] with apatite-related structure10.1016/j.jssc.2005.08.006 ↗
23. Defect chemistry and oxygen ion migration in the apatite-type materials La9.33Si6O26 and La8Sr2Si6O2610.1039/b302748c ↗
24. Preparation of germanium apatite and its cytotoxicity
25. The apatite structure without an inversion center in a new bismuth calcium vanadium oxide: BiCa4V3O1310.1006/jssc.1993.1140 ↗
26. Synthesis and characterization of new apatite-related phosphates10.1006/jssc.1999.8510 ↗
27. Antimicrobial and cytotoxicity evaluation of aliovalent substituted hydroxyapatite10.1016/j.apsusc.2014.02.166 ↗
28. A. Doyle, J.B. Griffiths, Cell and tissue culture for medical research. John Willey and Son׳s, U.K.
29. Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders10.1016/j.apsusc.2010.03.124 ↗
30. Cobalt-exchanged hydroxyapatite catalysts: magnetic studies, spectroscopic investigations, performance in 2-butanol and ethane oxidative hydrogenations10.1016/j.jcat.2004.05.007 ↗
31. In vitro bioactivity evaluation of magnesium-substituted fluorapatite nanopowders10.1016/j.ceramint.2011.05.157 ↗
32. Ionic substitutions in calcium phosphates synthesized at low temperature10.1016/j.actbio.2009.12.041 ↗
33. Fluor-chlor-oxy-apatite and sphene from crystal lode pegmatite near eagle Colorado
34. Kinetics of thermal decomposition of hydroxyapatite bioceramics10.1023/A:1004769820545 ↗
35. Cytotoxicity analysis of apatites modified with divalent metals10.4028/www.scientific.net/KEM.361-363.1135 ↗
36. Preparation, solubility, and cytocompatibility of zinc‐releasing calcium phosphate ceramics10.1002/(SICI)1097-4636(200005)50:2<178::AID-JBM12>3.0.CO;2-5 ↗