The ionic substituted octacalcium phosphate for biomedical applications: A new pathway to follow?
Source abstract
Abstract
Numerous studies have found that octacalcium phosphate possesses promising biological properties applicable to bone tissue regeneration. To further improve the osteogenic and regenerative properties of octacalcium phosphate, substitutions with Sr2+, Zn2+, Mg2+, Fe3+, Na+, F− and CO32− ions have been investigated in recent years. Despite that, hydroxyapatite is still considered the most promising calcium phosphate for bioactive bone grafts due to its biocompatibility, physicochemical similarity to biological apatite, osteoconductivity and strong bonding with the surrounding tissue. However, better biological properties of octacalcium phosphate in vivo as well as a larger volume of regenerated bone tissue, compared to hydroxyapatite, were confirmed by many studies. This review summarizes recent and relevant studies on cationic and anionic substitutions in the crystal lattice of octacalcium phosphate and its in vitro biological performance. It also discusses future challenges and prospects for the use of substituted octacalacium phosphate.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Bone Metabolism and Diseases · Bone health and treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (84)
Show source-provided references
1. Bone physiological microenviroment and healing mechanism: basis for future bone-tissue engineering scaffolds
2. Osteoporosis in the European union: medical management, epidemiology and economic burden. A report prepared in collaboration with the international osteoporosis foundation (IOF) and the European federation of pharmaceutical industry associations (EFPIA)10.1007/s11657-013-0136-1 ↗
3. Biological and medical significance of calcium phosphates10.1002/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1 ↗
4. Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics10.1016/j.tibtech.2013.06.005 ↗
5. Calcium orthophosphates: occurrence, properties and major applications10.4172/2090-5025.1000081 ↗
6. Biomimetic materials for bone tissue engineering – state of the art and future trends10.1002/adem.201080098 ↗
7. Effect of doping in hydroxyapatite as coating material on biomedical implants by plasma spraying method: a review10.1016/j.ceramint.2020.10.112 ↗
8. Bone mineral: new insights into its chemical composition10.1038/s41598-019-44620-6 ↗
9. Strontium substitution in bioactive calcium phosphates: a first-principles study10.1021/jp808713m ↗
10. First-principles study of substitutional magnesium and zinc in hydroxyapatite and octacalcium phosphate10.1063/1.2940337 ↗
11. Ionic substitutions in calcium phosphates synthesized at low temperature10.1016/j.actbio.2009.12.041 ↗
12. Applications of NMR crystallography to problems in biomineralization: refinement of the crystal structure and 31P solid-state NMR spectral assignment of octacalcium phosphate10.1021/ja3017544 ↗
13. Davies · Proc. Natl. Acad. Sci. Unit. States Am. · 2014 · 111 · 1354
14. VESTA 3 for three-dimensional visualization of crystal, volumetric and morphology data10.1107/S0021889811038970 ↗
15. Ion-doped hydroxyapatite: an impasse or the road to follow?10.1016/j.ceramint.2020.02.001 ↗
16. Ionic substituted hydroxyapatite for bone regeneration applications: a review10.1016/j.oceram.2021.100122 ↗
17. A comprehensive review on the preparation and application of calcium hydroxyapatite: a special focus on atomic doping methods for bone tissue engineering10.1016/j.ceramint.2021.07.100 ↗
18. Transformation of amorphous calcium phosphate to bone-like apatite10.1038/s41467-018-06570-x ↗
19. Octacalcium phosphate – a metastable mineral phase controls the evolution of scaffold forming proteins10.1039/C5TB00673B ↗
20. Solid-state NMR study of the transformation of octacalcium phosphate to hydroxyapatite: a mechanistic model for central dark line formation10.1021/ja060336u ↗
21. Calcium orthophosphates: crystallization and dissolution10.1021/cr0782574 ↗
22. Amorphous calcium (ortho)phosphates10.1016/j.actbio.2010.06.031 ↗
23. Intermediate states in the precipitation of hydroxyapatite10.1038/208365a0 ↗
24. Fluoride analysis of apatite crystals with a central planar OCP inclusion: concerning the role of F− ions on apatite/OCP/apatite structure formation10.1007/s002239900143 ↗
25. Enamel mineralization and an initial crystalline phase10.3109/03008209809017029 ↗
26. Calcium phosphates in biomedical applications: materials for the future?10.1016/j.mattod.2015.10.008 ↗
27. Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: indications for an amorphous precursor phase10.1073/pnas.0803354105 ↗
28. Mapping amorphous calcium phosphate transformation into crystalline mineral from the cell to the bone in zebrafish fin rays10.1073/pnas.0914218107 ↗
29. Transient amorphous calcium phosphate in forming enamel10.1016/j.jsb.2009.02.001 ↗
30. Bone mineralization proceeds through intracellular calcium phosphate loaded vesicles: a cryo-electron microscopy study10.1016/j.jsb.2011.03.014 ↗
31. Nanoanalytical electron microscopy reveals a sequential mineralization process involving carbonate-containing amorphous precursors10.1021/acsnano.6b02443 ↗
32. Bone mineralization pathways during the rapid growth of embryonic chicken long bones10.1016/j.jsb.2016.04.011 ↗
33. First evidence of octacalcium phosphate@osteocalcin nanocomplex as skeletal bone component directing collagen triple–helix nanofibril mineralization10.1038/s41598-018-31983-5 ↗
34. Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate10.1038/ncomms2490 ↗
35. Biochemical markers of bone turnover: part I: biochemistry and variability
36. The cell biology of bone metabolism10.1136/jcp.2007.048868 ↗
37. Bone tissue regeneration: biology, strategies and interface studies10.1007/s40204-019-00125-z ↗
38. Bone formation on synthetic precursors of hydroxyapatite10.1620/tjem.164.37 ↗
39. Comparative study on osteoconductivity by synthetic octacalcium phosphate and sintered hydroxyapatite in rabbit bone marrow10.1007/s00223-005-0170-0 ↗
40. Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite10.1016/j.biomaterials.2005.12.004 ↗
41. Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor10.1007/s10856-018-6162-1 ↗
42. Osteoconductive property of a mechanical mixture of octacalcium phosphate and amorphous calcium phosphate10.1021/am5067139 ↗
43. Capacity of octacalcium phiosphate to promote osteoblastic differentiation towards osteocytes in vitro10.1016/j.actbio.2018.01.026 ↗
44. Synthesis and structure of iron- and strontium-substituted octacalcium phosphate: effects of ionic charge and radius10.1039/C5TB02247A ↗
45. A thermostability perspective on enhancing physicochemical and cytological characteristics of octacalcium phosphate by doping iron and strontium
46. Cancellous-bone-like porous iron scaffold coated with strontium incorporated octacalcium phosphate nanowhiskers for bone regeneration10.1021/acsbiomaterials.8b01188 ↗
47. Effect of the ionic radius of alkali metal ions on octacalcium phosphate formation via different substitution modes10.1021/acs.cgd.9b00656 ↗
48. Sodium inhibits the formation of ammonium-substituted solid solutions of octacalcium phosphate by filling its substitution site10.1039/C8DT04697B ↗
49. Regulating the physicochemical and biological properties in vitro of octacalcium phosphate by substitution with strontium in a large doping range10.1016/j.mtchem.2017.07.003 ↗
50. Magnesium and strontium doped octacalcium phosphate thin films by matrix assisted pulsed laser evaporation10.1016/j.jinorgbio.2011.11.003 ↗
51. Strontium substituted octacalcium phosphate coatings by electrochemical deposition and their dose-dependent bioactivities10.1016/j.matlet.2020.127844 ↗
52. Strontium substituted biomimetic calcium phosphate system derived from cuttlefish bone10.1002/jbm.b.34515 ↗
53. Enhanced hydrated properties of α-tricalcium phosphate bone cement mediated by loading magnesium substituted octacalcium phosphate10.1016/j.apt.2017.10.006 ↗
54. Collapsed octacalcium phosphate stabilized by ionic substitutions, Cryst10.1021/cg100494f ↗
55. Effect of Zn2+ on the physicochemical characteristics of octacalcium phosphate and its hydrolysis into apatitic phases10.1021/cg1009835 ↗
56. Aesthetic silver-doped octacalcium phosphate powders exhibiting both contact antibacterial ability and low cytotoxicity10.1021/acsomega.0c02868 ↗
57. Prediction of sodium substitution sites in octacalcium phosphate: the relationships of ionic pair ratios in reacting solutions
58. Effect of the ionic radius of alkali metal ions on octacalcium phosphate formation via different substitution modes10.1021/acs.cgd.9b00656 ↗
59. Role of Mg2+, Sr2+, and F‒ ions in octacalcium phosphate crystallization10.1134/S0020168517120184 ↗
60. Synthesis and enhanced bone regeneration of carbonate substituted octacalcium phosphate
61. Overview of substitutes for bone Replacement: natural and synthetic products
62. Mimicking growth factors: role of small molecule scaffold additives in promoting tissue regeneration and repair10.1039/C9RA02765C ↗
63. Selenite substituted calcium phosphates: preparation, characterization, and cytotoxic activity10.3390/ma14123436 ↗
64. Bone grafts and biomaterials substitutes for bone defect repair: a review
65. Strontium and strontium ranelate: historical review of some of their functions10.1016/j.msec.2017.05.042 ↗
66. Crystal growth of calcium phosphates from aqueous solutions in the presence of strontium10.1016/j.ces.2012.02.049 ↗
67. Human mesenchymal stromal cells response to biomimetic octacalcium phosphate containing strontium10.1002/jbm.a.35725 ↗
68. Chemical stability, antibacterial and osteogenic activities study of strontium-silver co-substituted fluorohydroxyapatite nanopillars: a potential multifunctional biological coating10.1016/j.ceramint.2020.07.275 ↗
69. Strontium incorporation to optimize the antibacterial and biological characteristics of silver-substituted hydroxyapatite coating10.1016/j.msec.2015.08.061 ↗
70. Sodium induces octacalcium phosphate formation and enhances its layer structure by affecting the hydrous layer phosphate10.1021/acs.cgd.8b01030 ↗
71. Fabrication of silver-doped apatite powders from silver-substituted octacalcium phosphate powders via solid-solid phase-conversion process10.1016/j.ceramint.2021.05.287 ↗
72. Ion incorporation into octacalcium phosphate hydrolyzates10.1016/0022-0248(91)90247-3 ↗
73. Stoichiometry of K+- and CO32--containing apatites prepared by the hydrolysis of octacalcium phosphate10.1021/ic960213i ↗
74. Roles of fluoride on octacalcium phosphate and apatite formation on amorphous calcium phosphate substrate10.1021/acs.cgd.7b01717 ↗
75. Succinate-complexed octacalcium phosphate10.1246/bcsj.56.3843 ↗
76. Octacalcium phosphate carboxylates. 1. Preparation and identification10.1021/cm00034a007 ↗
77. Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain10.1039/C4DT03943B ↗
78. Incorporation of tetracarboxylate ions into octacalcium phosphate for the development of next-generation biofriendly materials10.1038/s42004-020-00443-5 ↗
79. Transformation of dicalcium phosphate dihydrate into octacalcium phosphate with incorporated dicarboxylate ions10.2109/jcersj2.18016 ↗
80. Synthesis of octacalcium phosphate with incorporated succinate and suberate ions10.1016/j.ceramint.2012.01.030 ↗
81. Understanding the steric structures of dicarboxylate ions incorporated in octacalcium phosphate crystals10.3390/ma14112703 ↗
82. 3D printing of calcium phosphate ceramics for bone tissue engineering and drug delivery10.1007/s10439-016-1678-3 ↗
83. Tris(hydroxymethyl)aminomethane substitution into octacalcium phosphate10.1246/cl.190553 ↗
84. Inorganic process for wet silica-doping of calcium phosphate10.1039/D1RA00288K ↗