Magnetic lamellar nanohydroxyapatite as a novel nanocarrier for controlled delivery of 5-fluorouracil
Source abstract
Abstract
Abstract Magnetic nanoparticles are attractive carriers for drug delivery and layered materials intercalated by drug molecules exhibit improved safety and effectiveness of drug delivery. In this work, we report the loading of a model anticancer drug, 5-fluorouracil (5FU), into a magnetic layered nanohydroxyapatite (ML-HAP) by intercalation technique. The as-prepared ML-HAP nanoparticles with loaded 5FU were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and vibrating sample magnetometer. We find that, within a certain drug concentration, the drug molecules can be intercalated into the gallery of ML-HAP without breaking its lamellar structure. The drug loading capacity of ML-HAP is extremely large. The drug release profiles display pH-dependent behavior and the drug release mechanisms are a combination of drug diffusion and HAP dissolution. Furthermore, ML-HAP/5FU shows strong superparamagnetism and good biocompatibility. The ML-HAP can be an efficient platform for targeted anticancer drug delivery.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Layered Double Hydroxides Synthesis and Applications · Bone Tissue Engineering Materials · Clay minerals and soil interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (51)
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