The importance of chitosan and nano-TiHA in cement-type composites on the basis of calcium sulfate
Source abstract
Abstract
Abstract The objective of this study was to combine titanium doped nano-hydroxyapatite with chitosan and calcium sulfate to obtain cement-type materials with improved cohesion and handling properties. It was proven that the presence of nano-TiHA influenced setting, hardening, microstructure and bioactivity of the cement samples. In the developed composites chitosan played a role of the cohesion promotor and created homogenous organic layers on the materials surfaces. Application of chitosan in acetic acid solution favorably delayed setting process of calcium sulfate dihydrate. The polymer combined with nano-TiHA and calcium sulfate improved handling and workability of the cements without diminishing their mechanical properties. It was suggested that the resorption rate of materials based on calcium sulfate can be optimized by addition of both titanium doped nano-hydroxyapatite and chitosan.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Dental materials and restorations
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (57)
Show source-provided references
1. Biomimetic Mg- and Mg, CO3-substituted hydroxyapatites: synthesis characterization and in vitro behavior10.1016/j.jeurceramsoc.2005.06.040 ↗
2. Magnesium- and strontium-co-substituted hydroxyapatite: the effects of doped-ions on the structure and chemico-physical properties10.1007/s10856-012-4767-3 ↗
3. Zinc-substituted hydroxyapatite: a biomaterial with enhanced bioactivity and antibacterial properties10.1007/s10856-012-4817-x ↗
4. Improving the osteogenic and angiogenic properties of synthetic hydroxyapatite by dual doping of bivalent cobalt and magnesium ion10.1016/j.ceramint.2015.05.090 ↗
5. Solid-state NMR study of Mn2+ for Ca2+ substitution in thermally processed hydroxyapatites10.1111/jace.13394 ↗
6. First-principles investigations of Ti-substituted hydroxyapatite electronic structure10.1039/B915171K ↗
7. Synthesis of rod-like titanium doped hydroxyapatite nanopowder
8. Comparison of photocatalytic activity and surface friction force variation on Ti-doped hydroxyapatite and anatase under UV illumination10.1016/j.jphotochem.2015.07.001 ↗
9. Effect of Ti ion substitution on the structure of hydroxylapatite10.1016/j.jeurceramsoc.2008.03.007 ↗
10. Evaluation of a setting reaction pathway in the novel composite TiHA–CSD bone cement by FT-Raman and FT-IR spectroscopy10.1016/j.molstruc.2012.10.044 ↗
11. The influence of titanium on physicochemical properties of Ti-modified hydroxyapatite
12. Desai · 2007
13. Novel non-rigid calcium phosphate scaffold seeded with umbilical cord stem cells for bone tissue engineering
14. Calcium phosphate bone graft substitutes: failures and hopes10.1016/j.jeurceramsoc.2012.02.028 ↗
15. Dual-setting brushite–silica gel cements10.1016/j.actbio.2014.09.036 ↗
16. Biocompatibility of calcium phosphate bone cement with optimized mechanical properties10.1002/jbm.b.33370 ↗
17. Development of a fully injectable calcium phosphate cement for orthopedic and dental applications10.1007/BF02711186 ↗
18. Nanomaterials: the next step in injectable bone cements10.2217/nnm.14.109 ↗
19. Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function10.1016/S0142-9612(99)00181-7 ↗
20. Biomaterial developments for bone tissue engineering10.1016/S0142-9612(00)00102-2 ↗
21. Bone regeneration with calcium sulfate: evidence for increased angiogenesis in rabbits10.1563/1548-1336(2002)028<0273:BRWCSE>2.3.CO;2 ↗
22. In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model10.1016/j.biomaterials.2004.02.014 ↗
23. A novel injectable magnesium/calcium sulfate hemihydrate composite cement for bone regeneration
24. The use of plaster of paris to fill defects in bone
25. Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute10.1302/0301-620X.86B1.14040 ↗
26. Biphasic calcium sulfate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications: in vitro study10.1088/1748-6041/5/2/025006 ↗
27. Osteogenic biphasic calcium sulphate dihydrate/iron-modified a-tricalcium phosphate bone cement for spinal applications: in vivo study10.1016/j.actbio.2009.07.010 ↗
28. Inorganic cements for biomedical application: calcium phosphate, calcium sulphate and calcium silicate10.1179/1743676114Y.0000000219 ↗
29. Alginate combined calcium phosphate cements: mechanical properties and in vitro rat bone marrow stromal cell responses10.1007/s10856-011-4296-5 ↗
30. Addition of sodium hyaluronate and the effect on performance of the injectable calcium phosphate cement10.1007/s10856-009-3728-y ↗
31. The influence of different cellulose ethers on both the handling and mechanical properties of calcium phosphate cements for bone substitution10.1016/j.actbio.2012.11.020 ↗
32. Application of β-1,3-glucan in production of ceramics-based elastic composite for bone repair
33. Influence of anti-washout agents on the rheological properties and injectability of a calcium phosphate cement10.1002/jbm.b.30678 ↗
34. Chitosan functional properties10.1023/A:1018524207224 ↗
35. Elsabee antifungal efficacy of chitosan and its Thiourea derivatives upon the growth of some sugar-beet pathogens10.1016/j.ijbiomac.2005.12.009 ↗
36. Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles10.1016/j.biomaterials.2005.11.036 ↗
37. Preparation and characterization of injectable chitosan-hydroxyapatite microspheres
38. Physicochemical properties and biomimetic behavior of α-TCP-chitosan based materials10.1016/j.ceramint.2013.10.142 ↗
39. Characterization and cytocompatibility of nano-hydroxyapatite/chitosan bone cement with the addition of calcium salts10.1002/jbm.b.31267 ↗
40. Effects of chitosan addition to self-setting bone cement
41. Chitosan/hydroxyapatite-based composites, Biotec
42. Standard test method for time setting of hydraulic-cement paste by gillmore needles in ASTM Annual Book of Standards, ASTM C266-15, American Society for Testing and Materials, West Conshohocken, PA. 19428–2959
43. The dynamics of capillary flow10.1103/PhysRev.17.273 ↗
44. Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride-containing bioactive glass10.1002/jbm.a.34724 ↗
45. Calcium sulphate hemihydrate hydration leading to gypsum crystallization10.1016/j.pcrysgrow.2007.01.002 ↗
46. Regeneration of bone in the presence of calcium sulfate10.1001/archotol.1980.00790310029007 ↗
47. (A13) C. Ergun, Effect of Ti ion substitution on the structure of hydroxyapatite, J. Eur. Ceram. Soc. 28, 2008, pp. 2137–2149.10.1016/j.jeurceramsoc.2008.03.007 ↗
48. Osteotransductive bone cements10.1243/0954411981534196 ↗
49. Formulation and setting times of some calcium orthophosphate cements: a pilot study10.1007/BF00120130 ↗
50. Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties10.1016/j.actbio.2013.11.001 ↗
51. J. Moisset, Plaster setting modifiers, presented at the16th Eurogypsum Congress Association of European Gypsum Industries, Brussels, Paper No. 1, 1985, pp.1–27
52. Effect of carboxylica acids on the morphology, physical characteristic and hydratation of α-hemihydrate plaster
53. Carboxylic acids: effective inhibitors for calcium sulfate precipitation?10.1180/minmag.2014.078.6.13 ↗
54. Contribution to the study of complexation of copper by chitosan and oligomers10.1016/S0032-3861(01)00685-1 ↗
55. Preparation, characterization and antimicrobial activity of chitosan–Zn complex10.1016/j.carbpol.2003.11.007 ↗
56. Mechanical and degradation behavior of polymer-calcium sulfate composites10.1007/s10856-006-8936-0 ↗
57. An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs)10.1016/j.msec.2015.01.092 ↗