TiO2 hollow spheres as a novel antibiotic carrier for the direct delivery of gentamicin
Source abstract
Abstract
Abstract The TiO 2 hollow spheres were synthesized using a green, cheap, and easy process, in which carbonaceous spheres were chosen as the removable template. The prepared materials were characterized by X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDX), Atomic force microscopy (AFM), Fourier Transform Infrared Spectroscopy (FTIR), and Brunauer–Emmett–Teller (BET) analysis. According to the results, the obtained mesoporous TiO 2 hollow spheres demonstrated an external diameters less than 200 nm with shell thickness around 40 nm. The antibacterial activities of the TiO 2 hollow spheres were evaluated against gram-positive ( Bacillus subtilis and Staphylococcus aureus ) and gram-negative ( Escherichia coli and Pseudomonas aeruginosa ). No antibacterial activity was found for TiO 2 hollow spheres in the used concentrations. TiO 2 hollow spheres were loaded with gentamycin as a selected antibiotic to magnify their benefits in biomedical applications. TiO 2 hollow spheres exhibited good antibiotic carrier activity for the direct delivery of gentamicin, which was attributed to interaction between gentamicin and surface due to their larger specific surface area, more abundant porous structure, and their spherical morphology. The application of TiO 2 hollow spheres as gentamicin carrier undoubtedly opens an avenue to use hollow sphere materials in other drug delivery applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Photocatalysis Techniques · TiO2 Photocatalysis and Solar Cells · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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