Mortality response of folate receptor-activated, PEG–functionalized TiO2 nanoparticles for doxorubicin loading with and without ultraviolet irradiation
Source abstract
Abstract
Abstract TiO 2 nanoparticles (NPs) were synthesized by hydrothermal assisted sol–gel technique. In the next step, as-synthesized NPs were modified by poly ethylene glycol (PEG). Then, folic acid (FA) was conjugated to TiO 2 –PEG. Finally, Doxorubicin (Dox) as an anticancer drug was loaded on as-prepared TiO 2 –PEG–FA nanocarrier. The optimization of TiO 2 and FA concentration and the influence of ultraviolet (UV) irradiation on photocatalytic activity of nanocarrier and Dox loaded carrier were assessed by utilizing the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT)-assay method. Results indicated that the effect of NPs on cancer cells killing is dose-dependent, optimized at 1.25 g/L. The performance of FA on the selective targeting was confirmed and maximized at FA/TiO 2 =0.5. As-optimized TiO 2 –PEG–FA–Dox conjugate, in comparison to pure Dox, was more effective as far as cancer cell viability reduced to about 5%, especially under UV irradiation.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Advanced Photocatalysis Techniques · TiO2 Photocatalysis and Solar Cells
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (33)
Show source-provided references
1. Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT10.1016/j.jphotobiol.2009.04.001 ↗
2. Killing of cancer cell line by photoexcitation of folic acid-modified titanium dioxide nanoparticles10.1016/j.jphotochem.2009.03.009 ↗
3. The in vitro inhibition of multidrug resistance by combined nanoparticulate titanium dioxide and UV irradiation10.1016/j.biomaterials.2006.03.021 ↗
4. The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers10.1016/j.biomaterials.2009.05.015 ↗
5. Bio-nanotechnology and photodynamic therapy – State of the art review10.1016/j.pdpdt.2008.02.001 ↗
6. Parameters affecting the photocatalytic degradation of dyes using TiO2-based photocatalysts: a review10.1016/j.jhazmat.2009.05.039 ↗
7. In vivo biocompatibility studies of nano TiO2 materials10.4028/www.scientific.net/AMR.79-82.389 ↗
8. Photoinduced reactivity of titanium dioxide10.1016/j.progsolidstchem.2004.08.001 ↗
9. TiO2 photocatalysis: a historical overview and future prospects10.1143/JJAP.44.8269 ↗
10. Highly water-dispersible TiO2 nanoparticles for doxorubicin delivery: effect of loading mode on therapeutic efficacy10.1039/c1jm13615a ↗
11. Sonodynamic therapy using water–dispersed TiO2 polyethylene glycol compound on glioma cells: comparison of cytotoxic mechanism with photodynamic therapy10.1016/j.ultsonch.2010.12.017 ↗
12. The preparation of TiO2 nanometer photocatalyst film by a hydrothermal method and its sterilization performance for Giardia lamblia10.1016/j.watres.2003.10.011 ↗
13. Disinfection of E. Coli by carbon modified TiO2 photocatalysts
14. In vitro effects of nanoparticles on renal cells10.1186/1743-8977-5-22 ↗
15. Physics and chemistry of photocatalytic titanium dioxide: visualization of bactericidal activity using atomic force microscopy
16. Agglomeration and sedimentation of TiO2 nanoparticles in cell culture medium10.1016/j.colsurfb.2008.09.014 ↗
17. Nanomedicines and nanotoxicology: some physiological principles10.1093/occmed/kql052 ↗
18. Colloidal stability of dextran and dextran/poly ethylene glycol coated TiO2 nanoparticles by hydrothermal assisted sol–gel method10.1016/j.ceramint.2013.04.018 ↗
19. Mesoporous properties of nanosized anatase titania powders prepared by urea hydrolysis with PEG dispersant10.1023/A:1025170926516 ↗
20. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake10.1016/S0142-9612(01)00267-8 ↗
21. Surface modification of monodisperse magnetite nanoparticles for improved intracellular uptake to breast cancer cells10.1016/j.jcis.2004.09.042 ↗
22. Byrappa · 2001 · 28
23. Application of the statistical Taguchi method to optimize TiO2 nanoparticles synthesis by the hydrothermal assisted sol–gel technique
24. Brinker · 1990 · 22
25. On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol–functionalized magnetite nanoparticles10.1016/j.actbio.2007.06.006 ↗
26. Effect of polyethylene glycol modification of TiO2 nanoparticles on cytotoxicity and gene expressions in human cell lines10.3390/ijms13033703 ↗
27. The hydrothermal synthesis of mesoporous TiO2 with high crystallinity, thermal stability, large surface area, and enhanced photocatalytic activity10.1016/j.apcata.2007.02.010 ↗
28. Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line10.1016/j.cellbi.2008.03.019 ↗
29. FTIR spectroscopy of biodegraded historical textiles10.1016/j.polymdegradstab.2010.12.016 ↗
30. Preparation of highly active photocatalyst anatase TiO2 by mixed template method10.1007/s10971-009-2029-8 ↗
31. Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery10.1016/j.msec.2010.01.006 ↗
32. Surface chemistry influences cancer killing effect of TiO2 nanoparticles10.1016/j.nano.2008.04.001 ↗
33. Selectivity of folate conjugated polymer micelles against different tumor cells10.1016/j.ijpharm.2007.07.040 ↗