Low-temperature aqueous synthesis and biocompatibility of manganese whitlockite
Source abstract
Abstract
In this work, manganese whitlockite (Mn-WH, Ca18Mn2(HPO4)2(PO4)12) was successfully synthesized andcomprehensively characterized. This material is a manganese-containing analog of the biomineral magnesiumwhitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis was performed via a low-temperature dissolutionprecipitation process in aqueous medium under ambient pressure at 75 ◦C using dicalcium phosphate dehydrateand manganese acetate tetrahydrate as starting materials. The crystal structure of the synthesized powder wasdetermined by powder X-ray diffraction, FTIR and Raman spectroscopies, demonstrating the presence of characteristic structural units. Morphological features and elemental distribution within the synthesized powder werestudied by SEM/EDX analysis. XPS, EPR and magnetic studies confirmed the presence of Mn ions in a divalentstate. Temperature-dependent magnetic measurements revealed a paramagnetic behavior of Mn-WH down to 5K. In vitro cytotoxicity experiments were performed with MC3T3-E1 preosteoblastic cell line.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Layered Double Hydroxides Synthesis and Applications · Geochemistry and Elemental Analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (58)
Show source-provided references
1. In vitro and in vivo evaluation of whitlockite biocompatibility: comparative study with hydroxyapatite and β-tricalcium phosphate10.1002/adhm.201400824 ↗
2. Micrometer-sized magnesium whitlockite crystals in micropetrosis of bisphosphonate-exposed human alveolar bone10.1021/acs.nanolett.7b02888 ↗
3. Morphology and chemical composition of dental calculi mainly composed of whitlockite
4. Magnesium whitlockite – omnipresent in pathological mineralisation of soft tissues but not a significant inorganic constituent of bone10.1016/j.actbio.2021.02.021 ↗
5. A novel injectable whitlockite-containing borosilicate bioactive glass cement for bone repair10.1016/j.jnoncrysol.2020.120291 ↗
6. Whitlockite-enabled hydrogel for craniofacial bone regeneration10.1021/acsami.1c07453 ↗
7. Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties10.1016/j.actbio.2013.11.001 ↗
8. Enhanced osteogenesis of hydroxyapatite scaffolds by coating with BMP-2-loaded short polylactide nanofiber: a new drug loading method for porous scaffolds
9. Synthesis of magnesium- and silicon-modified hydroxyapatites by microwave-assisted method10.1038/s41598-019-50777-x ↗
10. Poly-ε-caprolactone/Whitlockite electrospun bionic membrane with an osteogenic–angiogenic coupling effect for periosteal regeneration10.1021/acsbiomaterials.1c00426 ↗
11. Dissolution–precipitation synthesis and characterization of zinc whitlockite with variable metal content10.1021/acsbiomaterials.1c00335 ↗
12. Peculiarities of the formation, structural and morphological properties of zinc whitlockite (Ca18Zn2(HPO4)2(PO4)12) synthesized via a phase transformation process under hydrothermal conditions10.1039/D2CE00497F ↗
13. Copper whitlockite synthesized via hydrothermal transformation of calcium hydrogen phosphate dihydrate10.3363/prb.38.18 ↗
14. A copper-containing analog of the biomineral whitlockite: dissolution–precipitation synthesis, structural and biological properties10.1039/D3DT03756H ↗
15. Crystal structures of biocompatible Mg-, Zn-, and Co-whitlockites synthesized via one-step hydrothermal reaction10.1515/zkri-2023-0016 ↗
16. Surface phenomena enhancing the antibacterial and osteogenic ability of nanocrystalline hydroxyapatite, activated by multiple-ion doping10.1021/acsbiomaterials.9b00893 ↗
17. Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials10.1016/j.actbio.2019.03.055 ↗
18. Biological properties of copper-doped biomaterials for orthopedic applications: a review of antibacterial, angiogenic and osteogenic aspects10.1016/j.actbio.2020.09.044 ↗
19. Antimicrobial properties of co-doped tricalcium phosphates Ca3-2x(MˊMˊˊ)x(PO4)2 (M = Zn2+, Cu2+, Mn2+ and Sr2+)10.1016/j.ceramint.2022.06.237 ↗
20. Cerium-doped whitlockite nanohybrid scaffolds promote new bone regeneration via SMAD signaling pathway10.1016/j.cej.2018.11.116 ↗
21. Eu3+/Tb3+-doped whitlockite nanocrystals: controllable synthesis, cell imaging, and the degradation process in the bone reconstruction10.1007/s12274-021-3654-y ↗
22. Inorganic biomaterials for regenerative medicine10.1021/acsami.9b17801 ↗
23. Nutritional aspects of manganese homeostasis10.1016/j.mam.2005.07.003 ↗
24. Ross · 2020
25. Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats10.1007/s12011-008-8119-6 ↗
26. Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics10.1016/j.tibtech.2013.06.005 ↗
27. Effect of Mg2+, Sr2+, and Mn2+ on the chemico-physical and in vitro biological properties of calcium phosphate biomimetic coatings10.1016/j.jinorgbio.2009.09.009 ↗
28. Oxidative basis of manganese neurotoxicity10.1196/annals.1306.010 ↗
29. Recent progress on manganese-based nanostructures as responsive MRI contrast agents10.1002/chem.201802851 ↗
30. Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging10.1016/j.biomaterials.2009.02.001 ↗
31. Multifunctional hydroxyapatite nanoparticles for drug delivery and multimodal molecular imaging10.1007/s00604-015-1504-x ↗
32. Biodegradable manganese-doped calcium phosphate nanotheranostics for traceable cascade reaction-enhanced anti-tumor therapy10.1021/acsnano.9b05836 ↗
33. Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications10.1007/s10856-018-6070-4 ↗
34. Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants10.1016/j.biomaterials.2004.01.005 ↗
35. The crystal structure of manganese-whitlockite, Ca18Mn2H2(PO4)1410.1107/S0567740876002690 ↗
36. Dopamine and DNA functionalized manganese whitlockite nanocrystals for magnetic resonance imaging and chemo-photothermal therapy of tumors10.1016/j.colsurfb.2022.113120 ↗
37. Neodymium and manganese ions co-doped whitlockite for temperature monitoring, photothermal therapy, and bone tissue repair in osteosarcoma10.1016/j.jcis.2023.09.186 ↗
38. DNA aptamer functionalized monodisperse Eu/Mn-WH nanoparticle for in vivo magnetic resonance and fluorescence imaging10.1016/j.ceramint.2023.11.046 ↗
39. Neutron and XRD single-crystal diffraction study and vibrational properties of whitlockite, the natural counterpart of synthetic tricalcium phosphate10.3390/cryst11030225 ↗
40. Diamagnetic corrections and pascal's constants10.1021/ed085p532 ↗
41. Simple correction for the sample shape and radial offset effects on SQUID magnetometers: magnetic measurements on Ln2O3 (Ln=Gd, Dy, Er) standards10.1016/j.jssc.2014.10.026 ↗
42. Crystal structure of synthetic Mg-whitlockite, Ca18Mg2H2(PO4)1410.1139/v74-181 ↗
43. Dissolution-precipitation synthesis and thermal stability of magnesium whitlockite10.1039/D3CE00602F ↗
44. Revisiting whitlockite, the second most abundant biomineral in bone: nanocrystal synthesis in physiologically relevant conditions and biocompatibility evaluation10.1021/nn405246h ↗
45. Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): synthesis, structural, magnetic, mechanical and biological properties10.1016/j.msec.2020.110918 ↗
46. Effect of Mn doping on the low-temperature synthesis of tricalcium phosphate (TCP) polymorphs10.1016/j.jeurceramsoc.2019.03.057 ↗
47. Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984)10.1351/pac198557040603 ↗
48. Hydrothermal growth of whitlockite coating on β-tricalcium phosphate surfaces for enhancing bone repair potential10.1016/j.jmst.2017.07.009 ↗
49. Phase transformation from hydroxyapatite to the secondary bone mineral, whitlockite10.1039/C4TB01793E ↗
50. Crystal structure and EPR study of Mn-doped beta-tricalcium phosphate10.1016/j.materresbull.2007.02.031 ↗
51. EPR investigations of calcium phosphate glasses containing manganese ions10.1016/j.physb.2009.07.187 ↗
52. Conventional, pulsed and high-field electron paramagnetic resonance for studying metal impurities in calcium phosphates of biogenic and synthetic origins10.1016/j.jmmm.2018.02.039 ↗
53. Whitlockite (β-Ca3(PO4)2) characterization by XPS: an environmentally important mineral10.1116/1.1247924 ↗
54. Calcium phosphate phase identification using XPS and time-of-flight cluster SIMS10.1021/ac9806963 ↗
55. Resolving surface chemical states in XPS analysis of first row transition metals, oxides and hydroxides: Cr, Mn, Fe, Co and Ni10.1016/j.apsusc.2010.10.051 ↗
56. Core-level satellites and outer core-level multiplet splitting in Mn model compounds10.1116/1.582302 ↗
57. Synthesis, structural and luminescent properties of Mn-doped calcium pyrophosphate (Ca2P2O7) polymorphs10.1038/s41598-022-11337-y ↗
58. Synthesis and luminescent properties of Mn-doped alpha-tricalcium phosphate10.1016/j.ceramint.2020.10.114 ↗