journal article·2025-06

Effect of Fe-Mg co-incorporation on the mechanical properties, biodegradation, osteogenesis and immunoregulation in vitro of 3D printed biphasic calcium phosphate bioceramics

Dong Dong, Haijun Su, Jian Xing, Xiang Li, Zhonglin Shen, Hao Jiang, Minghui Yu, Min Guo, Zhuo Zhang, Pengfei Wang

Ceramics International· Volume 51· Issue 15
Publisher page

Abstract

No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.

Source: Not provided · Quality: missing

Research context

OpenAlex topics: Bone Tissue Engineering Materials · 3D Printing in Biomedical Research · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (76)

Show source-provided references
1. Materials design for bone-tissue engineering10.1038/s41578-020-0204-2 ↗
2. Biomaterials for bone tissue engineering10.1016/S1369-7021(08)70086-5 ↗
3. Bioceramics: from bone regeneration to cancer nanomedicine10.1002/adma.201101586 ↗
4. Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review10.1016/j.actbio.2011.11.017 ↗
5. Biphasic calcium phosphate ceramics for bone reconstruction: a review of biological response10.1016/j.actbio.2017.01.076 ↗
6. Biphasic calcium phosphates bioceramics (HA/TCP): concept, physicochemical properties and the impact of standardization of study protocols in biomaterials research10.1016/j.msec.2016.11.039 ↗
7. Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size
8. Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants
9. A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model10.1093/rb/rbaa040 ↗
10. 3D-printed biodegradable composite scaffolds with significantly enhanced mechanical properties via the combination of binder jetting and capillary rise infiltration process
11. Strategies of strengthening mechanical properties in the osteoinductive calcium phosphate bioceramics10.1093/rb/rbad013 ↗
12. A biomimetic piezoelectric scaffold with sustained Mg(2+) release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration
13. A new iron calcium phosphate material to improve the osteoconductive properties of a biodegradable ceramic: a study in rabbit calvaria10.1088/1748-6041/10/5/055012 ↗
14. Silicate-based bioceramic scaffolds for dual-lineage regeneration of osteochondral defect10.1016/j.biomaterials.2018.11.025 ↗
15. Promoting vascularized bone regeneration via strontium-incorporated hydroxyapatite bioceramic10.1016/j.matdes.2023.112313 ↗
16. Complementary and synergistic effects on osteogenic and angiogenic properties of copper-incorporated silicocarnotite bioceramic: in vitro and in vivo studies10.1016/j.biomaterials.2020.120553 ↗
17. Magnesia-doped HA/β-TCP ceramics and evaluation of their biocompatibility10.1016/S0142-9612(03)00538-6 ↗
18. Tailoring mechanical and in vitro biological properties of calciumsilicate based bioceramic through iron doping in developing future material10.1016/j.jmbbm.2022.105122 ↗
19. Calcium silicate scaffolds promoting bone regeneration via the doping of Mg2+ or Mn2+ ion10.1016/j.compositesb.2020.107937 ↗
20. Antibacterial PLA/Mg composite with enhanced mechanical and biological performance for biodegradable orthopedic implants10.1016/j.bioadv.2023.213523 ↗
21. A strategy for enhancing bioactivity and osseointegration with antibacterial effect by incorporating magnesium in polylactic acid based biodegradable orthopedic implant10.1016/j.ijbiomac.2023.127797 ↗
22. 3D‐printed tissue‐specific nanospike‐based adhesive materials for time‐regulated synergistic tumor therapy and tissue regeneration in vivo
23. 3D printed magnesium-doped β-TCP gyroid scaffold with osteogenesis, angiogenesis, immunomodulation properties and bone regeneration capability in vivo10.1016/j.bioadv.2022.212759 ↗
24. Effects of zinc, magnesium, and iron ions on bone tissue engineering10.1021/acsbiomaterials.2c00368 ↗
25. Three-dimensional-printed bioceramic scaffolds with osteogenic activity for simultaneous photo/magnetothermal therapy of bone tumors10.1021/acsbiomaterials.9b01095 ↗
26. Enhanced in vivo bone and blood vessel formation by iron oxide and silica doped 3D printed tricalcium phosphate scaffolds10.1007/s10439-018-2040-8 ↗
27. Interactive effects of cerium and copper to tune the microstructure of silicocarnotite bioceramics towards enhanced bioactivity and good biosafety10.1016/j.biomaterials.2022.121751 ↗
28. Complementary and synergistic design of bi‐layered double hydroxides modified magnesium alloy toward multifunctional orthopedic implants10.1002/adhm.202201367 ↗
29. Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures
30. Impact of structural features of Sr/Fe co-doped HAp on the osteoblast proliferation and osteogenic differentiation for its application as a bone substitute10.1016/j.msec.2020.110633 ↗
31. 3D printed bioactive glasses porous scaffolds with high strength for the repair of long-bone segmental defects10.1016/j.compositesb.2023.110582 ↗
32. Enhanced mechanical properties and biological responses of SLA 3D printed biphasic calcium phosphate bioceramics by doping bioactive metal elements10.1016/j.jeurceramsoc.2023.03.007 ↗
33. A comprehensive review of the photopolymerization of ceramic resins used in stereolithography
34. Rational design of nonstoichiometric bioceramic scaffolds via digital light processing: tuning chemical composition and pore geometry evaluation10.1186/s13036-020-00252-3 ↗
35. Fe-doped tricalcium phosphates: crystal structure and degradation behavior10.1088/2053-1591/abcee8 ↗
36. Mg-substituted hydroxyapatite nanopowders: Synthesis, thermal stability and sintering behaviour10.1016/j.jeurceramsoc.2009.04.038 ↗
37. Variations of structure and composition in magnesium incorporated hydroxyapatite/β-tricalcium phosphate10.1557/jmr.2006.0049 ↗
38. Synthesis and characterization of sintered Sr/Fe-modified hydroxyapatite bioceramics for bone tissue engineering applications10.1021/acsbiomaterials.9b01666 ↗
39. Development of cell-laden photopolymerized constructs with bioactive amorphous calcium magnesium phosphate for bone tissue regeneration via 3D bioprinting10.1016/j.ijbiomac.2024.131412 ↗
40. Influence of iron doping towards the physicochemical and biological characteristics of hydroxyapatite10.1016/j.ceramint.2020.10.084 ↗
41. Effect of Fe2O3 doping on color and mechanical properties of dental 3Y-TZP ceramics fabricated by stereolithography-based additive manufacturing10.1016/j.ceramint.2022.12.062 ↗
42. Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair10.1016/j.ceramint.2014.12.065 ↗
43. Effect of grain orientation and magnesium doping on beta-tricalcium phosphate resorption behavior10.1016/j.actbio.2019.02.045 ↗
44. Effects of iron on physical and mechanical properties, and osteoblast cell interaction in beta-tricalcium phosphate10.1007/s10439-016-1724-1 ↗
45. Effects of coatings on the mechanical properties of carbon fiber reinforced HAP composites10.1016/j.matlet.2004.05.086 ↗
46. The thermal expansion of pure metals: copper, gold, aluminum, nickel, and iron10.1103/PhysRev.60.597 ↗
47. On the dependence of the coefficient of thermal expansion on density10.1016/S0031-9201(98)00115-0 ↗
48. Synthesis and sintering of B, Sr, Mg multi-doped hydroxyapatites: structural, mechanical and biological characterization10.1016/j.jmbbm.2020.104230 ↗
49. Recent advances in bone tissue engineering scaffolds10.1016/j.tibtech.2012.07.005 ↗
50. Enhanced angiogenesis of biodegradable iron-doped octacalcium phosphate/poly(lactic-co-glycolic acid) scaffold for potential cancerous bone regeneration10.1016/j.apmt.2019.01.002 ↗
51. Additive manufacturing a novel bioceramic bone scaffold with MgO/Ca3(PO4)2: microstructure, mechanical property and controllable degradation behavior10.1016/j.jmrt.2023.10.083 ↗
52. Mechanically driving supersaturated Fe–Mg solid solution for bone implant: preparation, solubility and degradation10.1016/j.compositesb.2020.108564 ↗
53. Cryogenically 3D printed biomimetic scaffolds containing decellularized small intestinal submucosa and Sr2+/Fe3+ co-substituted hydroxyapatite for bone tissue engineering10.1016/j.cej.2021.133459 ↗
54. A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing10.1016/j.biomaterials.2020.120414 ↗
55. Additive manufacturing of bioactive and biodegradable porous iron-akermanite composites for bone regeneration10.1016/j.actbio.2022.06.009 ↗
56. Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway10.1016/j.biomaterials.2013.11.014 ↗
57. Unlocking the potential of iron-containing mesoporous bioactive glasses: orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts10.1016/j.colsurfa.2024.134188 ↗
58. Fe–Zn alloy, a new biodegradable material capable of reducing ROS and inhibiting oxidative stress10.1093/rb/rbae002 ↗
59. Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells10.1002/(SICI)1097-4636(199802)39:2<331::AID-JBM22>3.0.CO;2-E ↗
60. Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis
61. Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application
62. Controlled magnesium ion delivery system for in situ bone tissue engineering10.1016/j.jconrel.2022.08.036 ↗
63. Stepwise 3D-spatio-temporal magnesium cationic niche: nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification
64. The effects of ascorbic acid and iron co-supplementation on the proliferation of 3T3 fibroblasts10.3109/10715769609145658 ↗
65. Degradation particles derived from high-purity magnesium inhibit osteogenic differentiation through regulation of macrophage polarization10.1016/j.jmst.2022.08.029 ↗
66. Magnesium enhances osteogenesis of BMSCs by tuning osteoimmunomodulation
67. In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages
68. Distinct mechanisms of iron and zinc metal ions on osteo-immunomodulation of silicocarnotite bioceramics10.1016/j.mtbio.2024.101086 ↗
69. Angiogenic and immunomodulation role of ions for initial stages of bone tissue regeneration10.1016/j.actbio.2023.06.001 ↗
70. Bone physiological microenvironment and healing mechanism: basis for future bone-tissue engineering scaffolds
71. Iron overload promotes hemochromatosis-associated osteoarthritis via the mTORC1-p70S6K/4E-BP1 pathway10.1016/j.intimp.2024.111848 ↗
72. Iron reduces M1 macrophage polarization in RAW264.7 macrophages associated with inhibition of STAT110.1155/2017/8570818 ↗
73. Ironing out the details: how iron orchestrates macrophage polarization10.3389/fimmu.2021.669566 ↗
74. Iron-doped brushite bone cement scaffold with enhanced osteoconductivity and antimicrobial properties for jaw regeneration10.1016/j.ceramint.2021.05.309 ↗
75. Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration10.1016/j.biomaterials.2015.08.027 ↗
76. Bioactive Sr2+/Fe3+ co-substituted hydroxyapatite in cryogenically 3D printed porous scaffolds for bone tissue engineering10.1088/1758-5090/abcf8d ↗