Calcium deficient hydroxyapatite by precipitation: Continuous process by vortex reactor and semi-batch synthesis
Source abstract
Abstract
Abstract Precipitation of calcium deficient hydroxyapatite nanoparticles in an environmentally benign manner by using only dilute solutions of calcium hydroxide and phosphoric acid without pH adjustment and addition of other chemicals, and water, being the only by-product was investigated by using continuous flow Vortex Reactor (VR) and Semi-Batch Reactor (SBR). The effect of hydrodynamics by changing the Reynolds number of the jets providing residence times of 8.4 ms to 4.37 s for VR, and by changing the stirrer speed between 100 rpm (Re = 2656) and 1000 rpm (Re = 26560) for SBR, on the particle size, particle size distribution, and morphology of the particles was investigated for both systems. It has been shown that it is possible to produce pure phase hydroxyapatite nanoparticles in the desired morphology by changing production system, without resorting to additives. While VR produced rod-like particles with the crystallite size around 4 nm, SBR produced spherical particles with the crystallite size of around 5 nm.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrohydrodynamics and Fluid Dynamics · Calcium Carbonate Crystallization and Inhibition · Minerals Flotation and Separation Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (64)
Show source-provided references
1. Comprehensive review of preparation methodologies of nano hydroxyapatite10.13074/jent.2013.12.132058 ↗
2. A Facile chemical route to synthesize Zn doped hydroxyapatite nanorods for protein drug delivery10.1016/j.matchemphys.2018.04.117 ↗
3. Synthesis of monophasic Ag doped hydroxyapatite and evaluation of antibacterial activity10.1016/j.msec.2018.04.076 ↗
4. Wet chemical precipitation synthesis of hydroxyapatite (HA) powders10.1016/j.ceramint.2018.02.201 ↗
5. Facile synthesis of hydroxyapatite nanoparticles by a polymer-assisted method: morphology, mechanical properties and formation mechanism
6. Preparation and characterization of nano-hydroxyapatite powder using sol-gel technique10.1007/s12034-009-0069-x ↗
7. Advances in synthesis and functional modification of nanohydroxyapatite10.1155/2018/3106214 ↗
8. Hydroxyapatite nanocrystals: simple preparation, characterization and formation mechanism10.1016/j.msec.2014.08.058 ↗
9. Various parameters affecting the synthesis of the hydroxyapatite powders by the wet chemical precipitation technique
10. Characteristics and properties of hydoxyapatite derived by sol–gel and wet chemical precipitation methods10.1016/j.ceramint.2015.04.105 ↗
11. Comparative of the removal of Pb2+, Cd2+ and Ni2+ by nano crystallite hydroxyapatite from aqueous solutions: adsorption isotherm study10.1016/j.arabjc.2010.12.022 ↗
12. Effect of surfactant and heat treatment on morphology, surface area and crystallinity in hydroxyapatite nanocrystals10.1016/j.ceramint.2012.05.090 ↗
13. Synthesıs and characterızatıon of hydroxyapatıte nanopartıcles and its adsorptıon parameters for Zn (Iı) and reactıve yellow 4 dye in aqueous solutıon
14. Morphology controlled synthesis of nano-hydroxyapatite using polyethylene glycol as a template10.1016/j.jallcom.2016.09.117 ↗
15. Novel multiform morphologies of hydroxyapatite: synthesis and growth mechanism10.1016/j.apsusc.2015.11.123 ↗
16. Nanosized hydroxyapatite powders derived from coprecipitation process10.1023/A:1014355103125 ↗
17. A novel continuous industrial process for producing hydroxyapatite nanoparticles
18. Synthesis and characterization of nano-hydroxyapatite powder using wet chemical precipitation reaction10.1016/j.jmst.2013.10.011 ↗
19. The influence of hydroxyapatite nanoparticle morphology on embryonic development in a zebrafish exposure model10.3390/nano7040089 ↗
20. Effects of hydroxyapatite microparticle morphology on bone mesenchymal stem cell behavior10.1039/C4TB00424H ↗
21. Synthesis and characterization of hydroxyapatite nanocrystals via chemical precipitation technique
22. Synthesis of pure hydroxyapatite and the effect of synthesis conditions on its yield, crystallinity, morphology and mean particle size10.1080/01496390500385400 ↗
23. Preparation and characterization of nanostructured powders of hydroxyapatite
24. Tailoring the morphology of hydroxyapatite particles using a simple solvothermal route10.1016/j.ceramint.2016.12.022 ↗
25. Evaluation of hydroxyapatite crystallization in a batch reactor for the valorization of alkaline phosphate concentrates from wastewater treatment plants using calcium chloride10.1016/j.cej.2014.12.079 ↗
26. A simple method to control morphology of hydroxyapatite nano-and microcrystals by altering phase transition route10.1021/cg400308a ↗
27. Impact of morphology-influencing factors in lecithin-based hydroxyapatite precipitation10.1016/j.ceramint.2019.07.103 ↗
28. Effect of precipitation method on stoichiometry and morphology of hydroxyapatite nanoparticles10.4028/www.scientific.net/KEM.330-332.271 ↗
29. Effect of synthesis temperature on morphology and structural characteristics of hydroxyapatite whiskers10.13168/cs.2018.0010 ↗
30. Effect of concentration on nano hydroxyapatite powder by wet chemical precipitation route
31. Synthesis and characterisation of pure nanoporous hydroxyapatite
32. Facile development of nano size calcium hydroxyapatite based ceramic from eggshells: synthesis and characterization10.1007/s12649-017-9891-3 ↗
33. Advances in synthesis of calcium phosphate crystals with controlled size and shape10.1016/j.actbio.2014.06.017 ↗
34. Some characteristics of synthetic hydroxyapatite10.1023/A:1013080431495 ↗
35. Investigation of hydroxyapatite morphology at different experimental conditions
36. Influence of dispersant and heat treatment on the morphology of nanocrystalline hydroxyapatite10.1007/s11665-009-9569-5 ↗
37. Preparation of calcium hydroxyapatite nanoparticles using microreactor and their characteristics of protein adsorption10.1021/jp110441e ↗
38. Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability10.1016/j.biomaterials.2009.02.044 ↗
39. A facile vacuum assisted synthesis of nanoparticle impregnated hydroxyapatite composites having excellent antimicrobial properties and biocompatibility10.1016/j.ceramint.2017.10.051 ↗
40. Hydroxyapatite micro-and nanoparticles: nucleation and growth mechanisms in the presence of citrate species10.1016/j.jcis.2007.10.008 ↗
41. A simple method to controlled synthesis of nano hydroxyapatite in different particle size10.1016/j.matlet.2018.01.079 ↗
42. Study on the particle texture dependence of protein adsorption by using synthetic micrometer-sized calcium hydroxyapatite particles10.1016/S0927-7765(01)00227-2 ↗
43. Control of hydroxyapatite nanoparticle morphology using wet synthesis techniques: reactant addition rate effects10.1016/j.matlet.2014.05.105 ↗
44. A highly reproducible continuous process for hydroxyapatite nanoparticles synthesis10.1166/jnn.2009.NS06 ↗
45. High throughput methodology for continuous preparation of hydroxyapatite nanoparticles in a microporous tube-in-tube microchannel reactor10.1021/ie9005436 ↗
46. Process intensification and optimization for hydroxyapatite nanoparticles production10.1016/j.ces.2013.01.002 ↗
47. Production of sheet-like hydroxyapatite particles using a microreactor10.1246/bcsj.20120357 ↗
48. Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems10.1016/j.cej.2012.11.014 ↗
49. Precipitation of hydroxyapatite nanoparticles in 3D-printed reactors10.1016/j.cep.2018.10.001 ↗
50. A microscale multi-inlet vortex nanoprecipitation reactor: turbulence measurement and simulation10.1063/1.3125428 ↗
51. Confocal imaging of laminar and turbulent mixing in a microscale multi-inlet vortex nanoprecipitation reactor10.1063/1.3662042 ↗
52. Experimental characterization of turbulent mixing performance using simultaneous stereoscopic particle image velocimetry and planar laser-induced fluorescence10.1007/s00348-018-2669-y ↗
53. Liu
54. Nanoprecipitation in confined impinging jets mixers: production, characterization and scale-up of pegylated nanospheres and nanocapsules for pharmaceutical use10.1016/j.ces.2012.02.050 ↗
55. Flow characteristics in a scaled-up multi-inlet vortex nanoprecipitation reactor10.1021/ie5041836 ↗
56. Delayed detached eddy simulation of flow in macroscale and microscale multi-inlet vortex reactors10.1002/aic.15230 ↗
57. Mixing in a multi-inlet vortex mixer (MIVM) for flash nano-precipitation10.1016/j.ces.2007.10.020 ↗
58. Flow field simulation and mixing efficiency assessment of the multi-inlet vortex mixer for molybdenum sulfide nanoparticle precipitation10.1016/j.cej.2013.09.065 ↗
59. Production of TiO2 nanoparticles with controlled characteristics by means of a Vortex Reactor10.1016/j.cej.2008.10.031 ↗
60. Mixing strategies for zinc oxide nanoparticle synthesis via a polyol process10.1002/aic.14737 ↗
61. Synthesis and characterization of hydroxyapatite and gelatin doped with magnesium chloride for bone tissue engineering
62. Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity10.1351/pac198557040603 ↗
63. Recommendations for the characterization of porous solids10.1351/pac199466081739 ↗
64. Ultrasound-assisted crystallization (sonocrystallization)10.1016/j.ultsonch.2006.12.004 ↗