Osseointegration of sputtered SiC-added hydroxyapatite for orthopaedic applications
Source abstract
Abstract
Abstract Over the last few years, a trend in medical applications is to find solutions for metallic implants using coatings that can improve bioactivity and osseointegration. The goal of this study was to obtain and investigate sputtered hydroxyapatite coatings enriched with SiC to enhance the bioactivity and osseointegration of Ti alloys used in orthopaedic applications. The films were characterized in terms of phase composition, roughness, corrosion resistance in a synthetic body fluid (SBF) and in vitro biocompatibility with MG 63 osteoblast-like cells. All of the investigations were conducted using XRD, AFM, cell viability assays and proliferation tests. The results revealed that the addition of SiC had a positive influence on the properties of the sputtered hydroxyapatite. The addition of SiC led to an improvement in coating adhesion and corrosion resistance in an SBF solution over the HAP coating. All of the coatings presented cell viability values over 90%, revealing their suitability for medical applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (44)
Show source-provided references
1. On the mechanisms of biocompatibility10.1016/j.biomaterials.2008.04.023 ↗
2. Foreign body reaction to biomaterials10.1016/j.smim.2007.11.004 ↗
3. The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces10.1002/1097-4636(20011205)57:3<336::AID-JBM1176>3.0.CO;2-E ↗
4. The future of biologic coatings for orthopaedic implants10.1016/j.biomaterials.2013.01.074 ↗
5. Coatings and surface modifications imparting antimicrobial activity to orthopedic implants10.1002/wnan.1273 ↗
6. Calcium phosphate-based coatings on titanium and its alloys10.1002/jbm.b.30932 ↗
7. Nanocrystalline hydroxyapatite coatings from ultrasonated electrolyte: preparation, characterization, and osteoblast responses10.1002/jbm.a.31852 ↗
8. Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium10.1016/j.biomaterials.2005.10.041 ↗
9. Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis–a review10.1016/j.actbio.2013.10.036 ↗
10. Differentiation of mesenchymal stem cells onto highly adherent radio frequency-sputtered carbonated hydroxylapatite thin films10.1002/jbm.a.32947 ↗
11. Calcium phosphate coatings for bio-implant applications: Materials, performance factors, and methodologies10.1016/j.mser.2009.05.001 ↗
12. In vivo tensile testing of fluorapatite and hydroxylapatite plasma-sprayed coatings10.1002/jbm.820280506 ↗
13. In vivo mechanical and histological characteristics of HA-coated implants vary with coating vendor10.1002/jbm.820290215 ↗
14. Production of thin film silicon-doped hydroxyapatite via sputter deposition10.1023/B:JMSC.0000016213.77001.71 ↗
15. Surface modification of magnetron-sputtered hydroxyapatite thin films via silicon substitution for orthopaedic and dental applications10.1016/j.surfcoat.2010.12.012 ↗
16. Magnetron co-sputtered silicon-containing hydroxyapatite thin films – an in vitro study10.1016/j.biomaterials.2004.07.058 ↗
17. Enhancement of the mechanical properties of hydroxyapatite by SiC addition10.1016/j.jmbbm.2014.08.025 ↗
18. The corrosion and bioactivity behavior of SiC doped hydroxyapatite for dental applications10.1016/j.ceramint.2014.07.116 ↗
19. Corrosion resistance of amorphous hydrogenated SiC and diamond-like coatings deposited by r.f.-plasma-enhanced chemical vapour deposition10.1016/0257-8972(93)90156-I ↗
20. Corrosion and tribo-corrosion behavior of a-SiCx:H, a-SiNx:H and a-SiCxNy:H coatings on SS301 substrate10.1016/j.surfcoat.2009.10.018 ↗
21. Bioactivation of biomorphous silicon carbide bone implants10.1016/j.actbio.2010.06.036 ↗
22. Plasma-enhanced chemical vapor deposited silicon carbide as an implantable dielectric coating10.1002/jbm.a.10152 ↗
23. Magnetron sputtered SiC coatings as corrosion protection barriers for steels10.1016/S0257-8972(00)00976-2 ↗
24. Corrosion protection of an AISI 321 stainless steel by SiC coatings10.1016/S0257-8972(97)00622-1 ↗
25. Nanocrystalline 3C–SiC electrode for biosensing applications10.1021/ac201315q ↗
26. Selective streptavidin bioconjugation on silicon and silicon carbide nanowires for biosensor applications10.1557/jmr.2012.283 ↗
27. Investigation of the SiC thin films synthetized by Thermionic Vacuum Arc method (TVA)10.1140/epjd/e2012-20470-5 ↗
28. P, Human monocytes are stimulated by particles of hydroxyapatite and silicon carbide, but not by diamond: in vitro studies of new prosthesis coatings10.1016/0142-9612(96)89777-8 ↗
29. In vitro cellular responses to silicon carbide nanoparticles: impact of physico-chemical features on pro-inflammatory and pro-oxidative effects10.1007/s11051-012-1143-7 ↗
30. Effect of the deposition temperature on corrosion resistance and biocompatibility of the hydroxyapatite coatings10.1016/j.apsusc.2015.05.059 ↗
31. The influence of the deposition parameters on the properties of an rf-magnetron-deposited nanostructured calcium phosphate coating and a possible growth mechanism10.1016/j.surfcoat.2010.12.039 ↗
32. Influence of target surface degradation on the properties of r.f. Magnetron-sputtered calcium phosphate coatings10.1002/sia.1512 ↗
33. Influence of the substrate bias on the stoichiometry and structure of RF-magnetron sputter-deposited silver containing calcium phosphate coatings10.1002/mawe.201300101 ↗
34. Magnetron sputtering: a review of recent developments and applications10.1016/S0042-207X(99)00189-X ↗
35. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W310.1002/jbm.820240607 ↗
36. Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption10.1016/S0142-9612(00)00274-X ↗
37. surface characteristics of and in vitro behavior of osteoblast-like cells on titanium with nanotopography prepared by high-energy shot peening10.2147/IJN.S71625 ↗
38. Residual stress evaluation within hydroxyapatite coatings of different micrometer thicknesses10.1016/j.surfcoat.2015.02.040 ↗
39. Properties of passive film formed on CP titanium, Ti–6Al–4V and Ti–13.4Al–29Nb alloys in simulated human body conditions10.1016/j.intermet.2004.10.001 ↗
40. Baboian · 2005
41. Impedance study on the corrosion of PVD and CVD titanium nitride coatings10.4028/www.scientific.net/MSF.44-45.29 ↗
42. One- and two-dimensional polymer films ofmodified alkanethiol monolayers for preventing iron fromcorrosion10.1016/S0010-938X(98)00048-1 ↗
43. Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics10.1002/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9 ↗
44. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment10.1002/jbm.a.10098 ↗