Synergism in novel silver-copper/hydroxyapatite composites for increased antibacterial activity and biocompatibility
Source abstract
Abstract
Abstract This study develops a novel silver-copper/hydroxyapatite composite (Ag–Cu/HA) with high biocompatibility and antibacterial activity. Two different materials were synthesized, namely silver-hydroxyapatite (Ag-HA) and copper-hydroxyapatite (Cu-HA) composites, with 0.1%, 0.5%, and 1.0% (mol) of each metal. These materials were mixed in a planetary mill to obtain the Ag–Cu/HA composites. The results of our characterization demonstrated the low cytotoxicity and hemolytic response. The composite showed higher percent-inhibition for bacterial growth compared to those in separated composites of silver or copper with hydroxyapatite. Hence, these new materials promise higher efficacy as antibacterial hydroxyapatites.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (44)
Show source-provided references
1. Basic aspects of the mechanisms of bacterial resistence
2. Antibacterial and antioxidant activities for natural and synthetic dual-active compounds10.1016/j.ejmech.2018.09.009 ↗
3. WHO · 2018
4. Development of resistant strains ofStaphylococcus epidermidis on gentamicin-loaded bone cement in vivo10.1302/0301-620X.84B5.0840758 ↗
5. Antibiotic-loaded bio-materials and the risks for the spread of antibiotic resistance following theirprophylactic and therapeutic clinical use10.1016/j.biomaterials.2010.05.005 ↗
6. Vancomycin release behaviour fromamorphous calcium polyphosphate matrices intended for osteomyelitis treat-ment10.1016/j.biomaterials.2005.05.072 ↗
7. Microbial resistance in the current context and the importance of knowledge and application in antimicrobial policy
8. Antimicrobial activity and biocompatibility of Ag+ and Cu2+ doped biphasic hydroxyapatite/α-tricalcium phosphate obtained from hydrothermally synthesized Ag+ and Cu2+ doped hydroxyapatite10.1016/j.apsusc.2014.04.066 ↗
9. Main factors provoquing dental implant failure
10. Surface functionalization of biomaterials by radicalpolymerization10.1016/j.pmatsci.2016.04.005 ↗
11. Hydroxyapatite-based nanoparticles as a coating material for the dentine surface: an antibacterial and toxicological effect10.1016/j.ceramint.2019.08.260 ↗
12. Physico-chemical characterization and biocompatibility of hydroxyapatite derived from fish waste10.1016/j.jmbbm.2018.01.035 ↗
13. Hydroxyapatite/tricalcium silicate composites cement derived from novel two-step sol-gel process with good biocompatibility and applications as bone cement and potential coating materials10.1016/j.ceramint.2018.12.032 ↗
14. Microwave-assisted co-precipitation synthesis of high purity β-tricalcium phosphate crystalline powders10.1016/j.matchemphys.2011.05.075 ↗
15. Characterization and biocompatibility study of hydroxyapatite coating on the surface of titanium alloy10.1016/j.surfcoat.2019.07.067 ↗
16. Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix10.1016/j.msec.2019.109965 ↗
17. Synthesis of silver–hydroxyapatite composite with improved antibacterial properties10.1016/j.vacuum.2018.03.015 ↗
18. Bioactive Zn-doped hydroxyapatite coatings and their antibacterial efficacy against Escherichia +6coli and Staphylococcus aureus10.1016/j.surfcoat.2018.08.017 ↗
19. Electrophoretic-deposited hydroxyapatite-copper nanocomposite as an antibacterial coating for biomedical applications10.1016/j.surfcoat.2017.04.055 ↗
20. Pulsed laser deposition of copper and zinc doped hydroxyapatite coatings for biomedical applications10.1016/j.surfcoat.2017.11.006 ↗
21. Strontium and copper co-substituted hydroxyapatite-based coatings with improved antibacterial activity and cytocompatibility fabricated by electrodeposition10.1016/j.ceramint.2016.04.110 ↗
22. Antibacterial bone substitute of hydroxyapatite and magnesium oxide to prevent dental and orthopedic infections10.1016/j.msec.2018.12.059 ↗
23. Enhanced antibacterial activity, mechanical and physical properties of alginate/hydroxyapatite bionanocomposite film10.1016/j.ijbiomac.2018.05.104 ↗
24. Mg/Cu co-substituted hydroxyapatite – biocompatibility, mechanical properties and antimicrobial activity10.1016/j.ceramint.2019.07.219 ↗
25. (2018). Synergistic antibacterial activity of multi components in lysozyme/chitosan/silver/hydroxyapatite hybrid coating10.1016/j.matdes.2017.11.018 ↗
26. El mundo oculto de las interacciones farmacológicas en anestesia10.1016/j.rca.2017.05.003 ↗
27. Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions10.1016/j.msec.2014.05.071 ↗
28. Control of hydroxyapatite nanoparticle morphology using wet synthesis techniques: reactant addition rate effects10.1016/j.matlet.2014.05.105 ↗
29. Riss · 2004 · 1
30. CLSI · 2003
31. S. Qaiyumi, Macro- and Microdilution Methods of Antimicrobial Susceptibility Testing, in: R. Schwalbe, L. Steele-Moore, A.C. Goodwin (Eds.).
32. Synthesis and characterization of hydroxyapatite nanopowders by chemical precipitation, 10th WSEAS Int. Conf. EHAC’11 ISPRA’11, 3rd WSEAS
33. Copper substituted hydroxyapatite and fluorapatite: synthesis, characterization and antimicrobial properties10.1016/j.ceramint.2014.07.086 ↗
34. E ff ect of dopant loading on the structural features of silver-doped hydroxyapatite obtained by mechanochemical method10.1016/j.ceramint.2017.06.136 ↗
35. Sonochemical synthesis, characterization and photocatalytic properties of hydroxyapatite nano-rods derived from mussel shells10.1016/j.matlet.2017.03.016 ↗
36. Synthesis of hydroxyapatite nanorods for application in water defluoridation and optimization of process variables: advantage of ultrasonication with precipitation method over conventional method10.1016/j.ultsonch.2016.12.035 ↗
37. Structural properties of silver doped hydroxyapatite and their biocompatibility10.1016/j.msec.2012.12.042 ↗
38. Novel interconnected nanochannel hydroxyapatite ceramics: synthesis, microstructure, and permeability10.1016/j.ceramint.2016.12.113 ↗
39. Processing and properties of transparent hydroxyapatite and β tricalcium phosphate obtained by HIP process10.1016/j.ceramint.2012.06.023 ↗
40. Applied Surface Science Controlled electrophoretic deposition of HAp/β -TCP composite coatings on piranha treated 316L SS for enhanced mechanical and biological properties10.1016/j.apsusc.2015.06.111 ↗
41. Polyethylene glycol-assisted preparation of beta-tricalcium phosphate by direct precipitation method10.1016/j.powtec.2016.05.061 ↗
42. Valero · 2009
43. Ultra-trace silver-doped hydroxyapatite with non-cytotoxicity and effective antibacterial activity10.1016/j.msec.2015.05.078 ↗
44. 2018