Study on the new bone cement based on calcium sulfate and Mg, CO3 doped hydroxyapatite
Source abstract
Abstract
Abstract In order to improve some features of bone substitutes the new self-setting composite-type implant material based on Mg 2+ /CO 3 2− co-substituted hydroxyapatite (Mg-CHA) and calcium sulfate hemihydrate (CSH) was developed. Synthetic hydroxyapatites doped with small amounts of additives found in natural bone ( e.g. Mg 2+ and CO 3 2− ) are regarded as promising components of calcium phosphate bone cements (CPCs). The CPCs, now available on the market, due to low resorption rate are too stable to permit material degradation and are slowly replaced by the newly formed bone. To improve cement resorption we used calcium sulfate which is a well-known biodegradable and biocompatible bone defect filler. Combining properties of Mg-CHA and CSH allowed developing a new, promising, easy shapeable implant material with high potential for bone regeneration.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. New processing approaches in calcium phosphate cements and their applications in regenerative medicine10.1016/j.actbio.2010.01.036 ↗
2. Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment10.1016/j.biomaterials.2005.03.049 ↗
3. Calcium phosphate cement (CPC): a critical development path
4. Bioceramics of calcium orthophosphates10.1016/j.biomaterials.2009.11.050 ↗
5. Calcium phosphate cement: review of mechanical and biological properties10.1111/j.1532-849X.2006.00129.x ↗
6. Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements10.1016/j.matchemphys.2009.11.007 ↗
7. Calcium orthophosphate in medicine: from ceramic to calcium phosphate cements10.1016/S0020-1383(00)80022-4 ↗
8. Fabrication and mechanical properties of calcium phosphate cements (CPC) for bone substitution10.1016/j.msec.2010.10.014 ↗
9. Calcium orthophosphate cement for biomedical application10.1007/s10853-008-2527-z ↗
10. Calcium-deficient apatite: a first in vivo study concerning bone ingrowth10.1002/jbm.a.10518 ↗
11. In vivo mechanisms of hydroxyapatite ceramic degradation by osteoclasts: fine structural microscopy10.1002/jbm.a.10091 ↗
12. In vitro ageing of brushite calcium phosphate cement10.1016/S0142-9612(03)00293-X ↗
13. In vivo behavior of three different injectable hydraulic calcium phosphate cements10.1016/j.biomaterials.2003.08.073 ↗
14. In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line10.1016/j.biomaterials.2006.04.030 ↗
15. Biocompatibility and resorption of a brushite calcium phosphate cement10.1016/j.biomaterials.2004.11.056 ↗
16. Short-term implantation effects of a DCPD-based calcium phosphate cement10.1016/S0142-9612(97)00163-4 ↗
17. Histological, chemical, and crystallographic analysis of four calcium phosphate cements in different rabbits osseous sites10.1002/(SICI)1097-4636(199824)43:4<451::AID-JBM13>3.0.CO;2-Q ↗
18. Volume effect on biological properties of a calcium phosphate hydraulic cement: experimental study in sheep10.1016/S8756-3282(99)00147-7 ↗
19. The effect of calcium phosphate cement particles on osteoblast function10.1016/S0142-9612(99)00250-1 ↗
20. Formation of macropores in calcium phosphate cements trought the use of mannitol crystals
21. Preparation of macroporous calcium phosphate cement tissue engineering scaffold10.1016/S0142-9612(01)00401-X ↗
22. Calcium phosphate cement containing restorable fibres for short-term reinforcement and macroporosity10.1016/S0142-9612(01)00095-3 ↗
23. Incorporation of biodegradable electrospun fibres into calcium phosphate cement for bone regeneration10.1016/j.actbio.2009.10.036 ↗
24. Hydroxyapatite ceramics with selected sintering additives10.1016/S0142-9612(97)00019-7 ↗
25. Osteoblast response to hydroxyapatite doped with divalent and trivalent cations10.1016/j.biomaterials.2003.09.001 ↗
26. Influence of setting liquid composition and liquid-to-powder ratio on properties of a Mg-substituted calcium phosphate cement10.1016/j.actbio.2008.11.026 ↗
27. Cement from magnesium substituted hydroxyapatite10.1007/s10856-005-6986-3 ↗
28. Physico-chemical-mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphate10.1016/j.biomaterials.2006.10.018 ↗
29. Calcium phosphates in oral biology and medicine
30. Biomimetic Mg- and Mg,CO3-substituted hydroxyapatites: synthesis characterization and in vitro behavior10.1016/j.jeurceramsoc.2005.06.040 ↗
31. Processing of AB-type carbonated hydroxyapatite Ca10-x(PO4)6-x(CO3)x(OH)2-x-2y(CO3)y ceramics with controlled composition10.1016/j.jeurceramsoc.2007.06.009 ↗
32. Mechanochemical-hydrothermal synthesis of carbonated apatite powders at room temperature10.1016/S0142-9612(01)00158-2 ↗
33. Synergistic effects of magnesium and carbonate on properties of biological and synthetic apatites
34. FTIR and XRD evaluation of carbonated hydroxyapatite powders synthesized by wet methods10.1016/j.molstruc.2004.11.078 ↗
35. LeGeros · 1994 · 3
36. Incorporation of carbonate and magnesium ions into synthetic hydroxyapatite: the effect on physicochemical properties10.1016/j.molstruc.2010.11.058 ↗
37. Structural morphology of gypsum (CaSO4·2H2O), brushite (CaHPO4·2H2O) and pharmacolite (CaHAsO4·2H2O)10.1016/0022-0248(91)90376-G ↗
38. New hydraulic cements based on α-tricalcium phosphate-calcium sulfate dihydrate mixtures10.1016/S0142-9612(03)00573-8 ↗
39. Chitin and chitosan: properties and applications10.1016/j.progpolymsci.2006.06.001 ↗
40. Chitosan: a versatile biopolymer for orthopaedic tissue-engineering10.1016/j.biomaterials.2005.03.016 ↗
41. Chitosan: a versatile semi-synthetic polymer in biomedical applications10.1016/j.progpolymsci.2011.02.001 ↗
42. Calcium orthophosphate cements for biomedical application10.1007/s10853-008-2527-z ↗