Synthesis of near-infrared responsive gold nanorod-doped gelatin/hydroxyapatite composite microspheres with controlled photo-thermal property
Source abstract
Abstract
Abstract Gelatin/hydroxyapatite (HAp) composites are of great interest in the biomedical applications because of their excellent biocompatibility, biodegradability, and bioactivity. However, little attention has been paid to synthesis of the gelatin/HAp composites with photo-thermal property. In this study, near-infrared (NIR) responsive gold nanorod (GNR) doped gelatin/HAp composite microspheres were synthesized via an emulsion technique and their microstructure and NIR-responsive photo-thermal property were investigated. SEM observations showed that the composite microspheres were spherical and their diameter was ranged from 10 to 50 µm. XRD patterns showed that the composite microspheres presented the typical diffraction peaks of HAp and GNR components. FT-IR spectra showed that P-O-P bonds, -COOH groups and –NH2 groups were involved in the composite microspheres. Under an 808-nm NIR light irradiation, the temperature of the suspension of composite microspheres was increased from 37 °C to 42 °C due to the presence of GNR component, indicating that the composite microspheres possessed NIR-responsive photo-thermal property.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Collagen: Extraction and Characterization · Bone Tissue Engineering Materials · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (28)
Show source-provided references
1. Bioactive polysaccharide-based pH-sensitive polymers for cytoplasmic delivery of antigen and activation of antigen-specific immunity10.1016/j.biomaterials.2016.12.021 ↗
2. Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs10.1016/j.biomaterials.2008.03.025 ↗
3. A review of NIR dyes in cancer targeting and imaging10.1016/j.biomaterials.2011.06.024 ↗
4. Aldehyde-functionalized dendritic mesoporous silica nanoparticles aspotential nanocarriers for pH-responsive protein drug delivery10.1016/j.msec.2016.10.039 ↗
5. metal−organic framework/graphene quantum dot nanoparticles used for synergistic chemo- and photothermal therapy10.1021/acsomega.6b00385 ↗
6. Simple synthesis of multifunctional zeolitic imidazolate frameworks-8/graphene oxide nanocrystals with controlleddrug release and photothermal effect10.1016/j.micromeso.2016.09.036 ↗
7. Graphene quantum dots-capped magnetic mesoporous silica nanoparticles as a multifunctional platformfor controlled drug delivery, magnetic hyperthermia, and photothermal therapy10.1002/smll.201602225 ↗
8. Mesoporous silica nanoparticles capped with graphene quantum dots for potential chemo-photothermal synergistic cancer therapy10.1021/acs.langmuir.6b04189 ↗
9. Multifunctional gold-based nanocomposites for theranostics10.1016/j.biomaterials.2016.08.040 ↗
10. Gold nanorod-based localized surface plasmon resonance biosensors: a review10.1016/j.snb.2014.01.056 ↗
11. Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation10.1016/j.biomaterials.2013.01.051 ↗
12. Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods10.1016/j.polymer.2015.12.047 ↗
13. Preparation and characterization of gelatin–hydroxyapatite composite microspheres for hard tissue repair10.1016/j.msec.2015.07.047 ↗
14. Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study10.1016/j.msec.2017.02.172 ↗
15. Preparation, characterization and in vitro release of gentamicin from coralline hydroxyapatite–gelatin composite microspheres10.1016/S0142-9612(02)00066-2 ↗
16. Functional and bioactive properties of collagen and gelatin from alternative sources: a review10.1016/j.foodhyd.2011.02.007 ↗
17. Hydroxyapatite: a review of syntheses, structure and applications in heterogeneous catalysis10.1016/j.ccr.2017.06.009 ↗
18. Physicochemical and mechanical properties of freeze cast hydroxyapatite-gelatin scaffolds with dexamethasone loaded PLGA microspheres for hard tissue engineering applications10.1016/j.msec.2016.06.079 ↗
19. Novel gamma irradiated agarose-gelatin-hydroxyapatite nanocomposite scaffolds for skin tissue regeneration10.1016/j.ceramint.2016.04.001 ↗
20. Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite10.1016/j.msec.2016.12.111 ↗
21. Fabrication of novel Si-doped hydroxyapatite/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration10.1016/j.actbio.2014.12.021 ↗
22. Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration10.1021/bm1006344 ↗
23. Microsphere of apatite-gelatin nanocomposite as bone regenerative fillers
24. Selective protein adsorption property and characterization of nano-crystalline zinc-containing hydroxyapatite10.1016/j.actbio.2005.09.002 ↗
25. Growth mechanism of gold nanorods10.1021/cm303659q ↗
26. Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions10.1016/j.addr.2011.03.005 ↗
27. Collagen-templated sol–gel fabrication, microstructure, in vitro apatite deposition, and osteoblastic cell MC3T3-E1 compatibility of novel silica nanotube compacts10.1039/c0jm03823g ↗
28. Synthesis and tuning of gold nanorods with surface plasmon resonance10.1016/j.optmat.2017.01.004 ↗