Novel scaffolds based on hydroxyapatite/poly(vinyl alcohol) nanocomposite coated porous TiO 2 ceramics for bone tissue engineering
Source abstract
Abstract
Abstract The work is focused on the preparation of novel tissue engineering scaffolds with suitable initial mechanical properties and favorable microstructure based on biodegradable polymer/inorganic nanocomposite and porous ceramic. Macroporous TiO2 scaffolds with pore sizes ranging from 100 to 500 μm were obtained by the polyurethane foam replication method. Uniform, a few micrometers thin coating composed of hydroxyapatite synthesized in presence of poly(vinyl alcohol) were obtained on the porous TiO2 scaffolds through vacuum-assisted impregnation method while the original macroporosity and open pore structure of the TiO2 scaffolds were maintained. The mechanical strength as well as degradation and in vitro bioactivity of the scaffolds were characterized. The results showed that combination of hydroxyapatite/poly(vinyl alcohol) nanocomposite coatings and porous TiO2 ceramic leads to composite material with improved mechanical properties by achieving the initial mechanical strength up to 0.99±0.19 MPa and enhanced in vitro bioactivity.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Dental materials and restorations
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (33)
Show source-provided references
1. Evolution of bioceramics within the field of biomaterials10.1016/j.crci.2009.03.004 ↗
2. Regeneration of trabecular bone using porous ceramics10.1016/j.cossms.2003.09.012 ↗
3. A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering10.1016/j.biomaterials.2003.10.007 ↗
4. Fabrication and characterization of porous bioceramic composites based on hydroxyapatite and titania10.1016/j.matchemphys.2007.01.015 ↗
5. Processing of highly porous TiO2 bone scaffolds with improved compressive strength10.1016/j.jeurceramsoc.2012.08.016 ↗
6. Porous ceramic titanium dioxide scaffolds promote bone formation in rabbit peri-implant cortical defect model10.1016/j.actbio.2012.09.009 ↗
7. Effect of ZrO2 addition on the mechanical properties of porous TiO2 bone scaffolds10.1016/j.msec.2012.04.014 ↗
8. Polymer-bioceramic composites for tissue engineering scaffolds10.1007/s10853-008-2552-y ↗
9. TiO2 foams with poly-(D,L-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds10.1007/s10853-008-2858-9 ↗
10. Nanobioceramic coatings for biomedical applications10.1179/175355510X12723642365449 ↗
11. Recent progress in inorganic and composite coatings with bactericidal capability for orthopedic applications10.1016/j.nano.2010.10.005 ↗
12. Electrodeposition of hydroxyapatite-silver-chitosan nanocomposite coatings10.1016/j.surfcoat.2008.01.022 ↗
13. Synthesis of poly(vinyl alcohol)-hydroxyapatite composites and characterization of their bioactivity
14. Bioactivity evaluation of synthetic nanocrystalline hydroxyapatite
15. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective10.1002/term.24 ↗
16. Comparative investigation on the adhesion of hydroxyapatite coating on Ti–6Al–4V implant: a review paper10.1016/j.ijadhadh.2013.09.030 ↗
17. Deposition behavior and characteristics of hydroxyapatite coatings on Al2O3, Ti, and Ti6Al4V formed by a chemical bath method10.1016/j.ceramint.2013.10.109 ↗
18. Hydroxyapatite coating on zirconia10.1016/j.msec.2006.03.009 ↗
19. Development of tissue scaffolds using selective laser sintering of polyvinylalcohol/ hydroxyapatite biocomposite for craniofacial and joint defects10.1023/B:JMSM.0000046393.81449.a5 ↗
20. S. Nkhwa, K.F. Lauriaga, E. Kemal, S. Deb, Poly(vinyl alcohol): physical approaches to designing biomaterials for biomedical applications, Conference Papers in Science, 2014, Article ID 403472.10.1155/2014/403472 ↗
21. Polyvinylalcohol–collagen–hydroxyapatite biocomposite nanofibrous scaffold: mimicking the key features of natural bone at the nanoscale level10.1016/j.polymer.2009.12.046 ↗
22. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering10.1016/j.biomaterials.2006.01.039 ↗
23. In situ synthesis and characterization of nano-size hydroxyapatite in poly(vinylalcohol) matrix10.1016/j.ceramint.2006.06.006 ↗
24. An in situ hydrothermal fabrication process of poly (vinyl alcohol)/apatite-like nanocomposites with improved thermal and mechanical properties10.1016/j.ceramint.2013.08.057 ↗
25. Biomimetic synthesis of hybrid nanocomposite scaffolds by freeze-thawing and freeze-drying10.1007/s12034-008-0067-4 ↗
26. The influence of titania/hydroxyapatite composite coatings on in vitro osteoblasts behavior10.1016/S0142-9612(00)00269-6 ↗
27. Poly(vinyl alcohol)–hydroxyapatite biomimetic scaffold for tissue regeneration10.1016/j.msec.2006.02.008 ↗
28. Multifunctional properties of hydroxyapatite/titania bio-nano-composites: bioactivity and antimicrobial studies10.1016/j.powtec.2012.06.001 ↗
29. A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications10.1002/jbm.b.32694 ↗
30. Friction properties of nano-hydroxyapatite reinforced poly(vinyl alcohol) gel composites as an articular cartilage10.1016/j.wear.2008.08.012 ↗
31. IR-analysis of H-bonded H2O on the pure TiO2 surface10.1016/j.molstruc.2003.12.057 ↗
32. Preparation of hybrid biomaterials for bone tissue engineering10.1590/S1516-14392007000100006 ↗
33. Ultra-porous titanium dioxide scaffold with high compressive strength