Chitosan/sodium alginate modificated graphene oxide-based nanocomposite as a carrier for drug delivery
Source abstract
Abstract
Abstract The anti-cancer drug loaded nanocarrier of functionalized graphene oxide (GO) with chitosan (CS) and sodium alginate (SA) was prepared successfully through electrostatic self-assembly process. The anti-cancer drug doxorubicin hydrochloride (DOX) was incorporated into the nanocomposites and the resulted DOX-loaded products displayed significant pH-dependent drug release behaviors. The modification of GO with CS and SA increased the solubility of both GO and DOX loaded GO nanocomposites as well as limited the undesired non-specific adsorption of protein in physiological conditions. Additionally, the GO-CS/SA nanocomposites could be internalized by MCF-7 cancer cells and the DOX loaded compositions displayed a remarkable cytotoxicity to the tumor cells. Therefore, the GO-CS/SA nanoparticles proved to be potential materials for delivery of anti-tumor drugs.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery · Graphene research and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
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