Structural characterization, in vitro bioactivity, and antibacterial evaluation of low silver-doped bioactive glasses
Source abstract
Abstract
Abstract Four bioactive glasses (70 SiO2-(20-X) CaO-10 P2O5) containing low concentrations of silver (X Ag2O; where X = 0.5, 1, and 1.5 mol%) were synthesized by the conventional sol-gel method. Physical and structural characterization was realized using Fourier Transform Infrared (FT-IR), Thermogravimetric Analysis (TGA), X-ray Diffraction analysis (XRD), and Scanning Electron Microscopy (SEM-EDX). Acellular bioactivity tests were performed by immersion in the SBF solution. Escherichia coli and Staphylococcus aureus were used to evaluate the antibacterial activity of the prepared Ag-doped bioglasses. While FTIR, DRX, and SEM analysis displayed good acellular bioactivity for all bioactive glasses (Ag–70S), the antibacterial activity confirms well the bactericidal effect of 70S 1Ag and 70S 1.5Ag through total growth inhibition (100%) of the two pathogenic bacteria. It is also important to mention that low silver-doped bioglass nanoparticles (Ag2O ≤ 1.5 mol%) could be a required multifunctional candidate in bone tissue engineering.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Laser-Ablation Synthesis of Nanoparticles · Facial Trauma and Fracture Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. The story of Bioglass®10.1007/s10856-006-0432-z ↗
2. Optimized bioactive glass: the quest for the Bony Graft10.1002/adhm.201801542 ↗
3. Bioactive sol-gel glasses: processing, properties, and applications10.1111/ijac.12873 ↗
4. Can bioactivity be tested in vitro with SBF solution?10.1016/j.biomaterials.2009.01.008 ↗
5. Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments10.1098/rsif.2011.0611 ↗
6. Enhanced mechanical and biocompatible properties of strontium ions doped mesoporous bioactive glass10.1016/j.compositesb.2020.108099 ↗
7. Tantalum doped SiO2-CaO-P2 O5 based bioactive glasses: investigation of in vitro bioactivity and antibacterial activities
8. Bivalent cationic ions doped bioactive glasses: the influence of magnesium, zinc, strontium and copper on the physical and biological properties10.1007/s10853-017-1010-0 ↗
9. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics10.1016/j.biomaterials.2011.01.004 ↗
10. Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants10.1002/jbm.10270 ↗
11. Evaluation of in vitro and in vivo biocompatibility and structure of cobalt-releasing sol-gel bioactive glass10.1016/j.ceramint.2018.08.022 ↗
12. Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications
13. Human mesenchymal stem cells differentiate into an osteogenic lineage in presence of strontium containing bioactive glass nanoparticles10.1016/j.actbio.2019.03.038 ↗
14. In vitro studies of antibacterial activity of bioglasses releasing Ag+10.4028/www.scientific.net/KEM.493-494.108 ↗
15. A comprehensive study on copper incorporated bio-glass matrix for its potential antimicrobial applications10.1016/j.ceramint.2020.08.149 ↗
16. Mesoporous bioactive glasses: promising platforms for antibacterial strategies10.1016/j.actbio.2018.09.052 ↗
17. Fabrication of silver nanoparticles employing the cyanobacterium Spirulina platensis and its bactericidal effect against opportunistic nosocomial pathogens of the respiratory tract10.1016/j.molstruc.2020.128392 ↗
18. Interspecies interactions can enhance Pseudomonas aeruginosa tolerance to surfaces functionalized with silver nanoparticles10.1016/j.colsurfb.2020.111027 ↗
19. Influence of silver on the structure, dielectric and antibacterial effect of silver doped bioglass-ceramic nanoparticles10.1016/j.ceramint.2016.11.003 ↗
20. Optimization of silver-containing bioglass nanoparticles envisaging biomedical applications10.1016/j.msec.2018.09.027 ↗
21. Fabrication and multiscale characterization of 3D silver containing bioactive glass-ceramic scaffolds
22. Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition10.1016/j.msec.2020.111693 ↗
23. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment10.1007/s11051-010-9900-y ↗
24. The influential factors on antibacterial behaviour of copper and silver nanoparticles10.1080/00194506.2015.1026950 ↗
25. In vitro evaluation of cytotoxicity of silver-containing borate bioactive glass10.1002/jbm.b.31735 ↗
26. Facile synthesis of hollow mesoporous bioactive glass sub-micron spheres with a tunable cavity size10.1016/j.matlet.2014.07.041 ↗
27. How useful is SBF in predicting in vivo bone bioactivity?10.1016/j.biomaterials.2006.01.017 ↗
28. Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity10.1039/C9RA01133A ↗
29. Taufik · 2018
30. Effects of transition metal ion dopants (Ag, Cu and Fe) on the structural, mechanical and antibacterial properties of bioactive glass10.1016/j.colsurfa.2017.11.023 ↗
31. Coating of bone-like apatite for development of bioactive materials for bone reconstruction10.1088/1748-6041/2/4/R01 ↗
32. Bioactive glass: an in-vitro comparative study of doping with nanoscale copper and silver particles10.1111/ijag.12061 ↗
33. Antibacterial effects and dissolution behavior of six bioactive glasses10.1002/jbm.a.32564 ↗
34. Chudobova · 2014 · 10
35. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli10.1128/AEM.02001-07 ↗