Effects of pore size on the mechanical and biological properties of stereolithographic 3D printed HAp bioceramic scaffold
Source abstract
Abstract
Abstract In this study, hydroxyapatite (HAp) scaffolds with the pore size of 400, 500, and 600 μm were prepared by stereolithographic 3D printing (SL-3DP). The effects of pore size on mechanical and biological properties of the HAp scaffolds were investigated. Firstly, the macro- and microstructure of the HAp scaffolds were observed. Then, the compressive strength of the HAp scaffolds were tested. Finally, the biological properties of the HAp scaffolds were further characterized in vitro by the synthetic body fluid (SBF) solution immersion testing, as well as by using the cell proliferation and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. From this study, it was found that the HAp scaffold with a pore size of 600 μm had the most promising application prospect.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Additive Manufacturing and 3D Printing Technologies · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (53)
Show source-provided references
1. Unraveling the mechanical strength of biomaterials used as a bone scaffold in oral and maxillofacial defects10.1016/S1348-8643(18)30005-3 ↗
2. Design and fabrication of 3D printed scaffolds with a mechanical strength comparable to cortical bone to repair large bone defects10.1038/srep19468 ↗
3. Custom repair of mandibular bone defects with 3D printed bioceramic scaffolds10.1177/0022034517734846 ↗
4. A dual functional bone-defect-filling material with sequential antibacterial and osteoinductive properties for infected bone defect repair10.1002/jbm.a.36744 ↗
5. Bone regenerative medicine in oral and maxillofacial region using a three-dimensional printer10.1089/ten.tea.2016.0543 ↗
6. A review of synthesis methods, properties and use of monetite cements as filler for bone defects10.1016/j.ceramint.2021.01.240 ↗
7. Development of biodegradable porous scaffolds for tissue engineering10.1016/S0928-4931(01)00338-1 ↗
8. Individual tissue-engineered bone in repairing bone defects: a 10-year follow-up study10.1089/ten.tea.2019.0287 ↗
9. Coating biopolymer nanofibers with carbon nanotubes accelerates tissue healing and bone regeneration through orchestrated cell- and tissue-regulatory responses10.1016/j.actbio.2020.03.012 ↗
10. Mg bone implant: features, developments and perspectives10.1016/j.matdes.2019.108259 ↗
11. The effect of magnesium on bioactivity, rheology and biology behaviors of injectable bioactive glass-gelatin-3-glycidyloxypropyl trimethoxysilane nanocomposite-paste for small bone defects repair10.1016/j.ceramint.2021.01.110 ↗
12. Superior biological performance and osteoinductive activity of Si-containing bioactive bone regeneration particles for alveolar bone reconstruction10.1016/j.ceramint.2019.08.269 ↗
13. A review of bioceramic porous scaffolds for hard tissue applications: effects of structural features10.1016/j.ceramint.2020.03.192 ↗
14. Preparation of high-strength β-CaSiO3 bioceramic with B2O3 and SiO2 sintering additives10.1016/j.ceramint.2020.07.086 ↗
15. Bioceramic fibrous scaffolds built with calcium silicate/hydroxyapatite nanofibers showing advantages for bone regeneration10.1016/j.ceramint.2021.03.234 ↗
16. Hydroxyapatite nano bioceramics optimized 3D printed poly lactic acid scaffold for bone tissue engineering application10.1016/j.ceramint.2019.10.057 ↗
17. Effect of zinc ions on the structural characteristics of hydroxyapatite bioceramics10.1016/j.ceramint.2020.02.192 ↗
18. Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration10.1007/s00784-020-03700-y ↗
19. Alliance of gallium and strontium potently mediates the osteoclastic and osteogenic activities of β-tricalcium phosphate bioceramic scaffolds10.1016/j.cej.2021.128709 ↗
20. Influences of gallium substitution on the phase stability, mechanical strength and cellular response of β-tricalcium phosphate bioceramics10.1016/j.ceramint.2020.03.195 ↗
21. Study of nanoscale deformation mechanisms in bulk hexagonal hydroxyapatite under uniaxial loading using molecular dynamics10.1016/j.jmbbm.2020.103894 ↗
22. One pot method to synthesize three-dimensional porous hydroxyapatite nanocomposite for bone tissue engineering10.1007/s10934-019-00805-y ↗
23. Microstructures and cell reaction of porous hydroxyapatite coatings on titanium discs using a novel vapour-induced pore-forming atmospheric plasma spraying10.1016/j.surfcoat.2020.125837 ↗
24. Hydroxyapatite scaffolds containing copper for bone tissue engineering10.1007/s10971-020-05285-0 ↗
25. Process-structure-quality relationships of three-dimensional printed poly(caprolactone)-hydroxyapatite scaffolds10.1089/ten.tea.2019.0237 ↗
26. Mechanical strength improvement of chitosan/hydroxyapatite scaffolds by coating and cross-linking10.1016/j.jmbbm.2020.104169 ↗
27. A novel modification for polymer sponge method to fabricate the highly porous composite bone scaffolds with large aspect ratio suitable for repairing critical-sized bone defects10.1016/j.vacuum.2020.109316 ↗
28. Developing porous diopside/hydroxyapatite bio-composite scaffolds via a combination of freeze-drying and coating process10.1016/j.ceramint.2019.01.236 ↗
29. Epoxy-based gelcasting of machinable hydroxyapatite foams for medical applications10.1111/jace.15523 ↗
30. Evaluation of structural and mechanical properties of porous artificial bone scaffolds fabricated via advanced TBA-based freeze-gel casting technique10.3390/app9091965 ↗
31. Effect of hydroxyapatite on biodegradable scaffolds fabricated by SLS
32. Highly loaded hydroxyapatite microsphere/PLA porous scaffolds obtained by fused deposition modelling10.1016/j.ceramint.2018.07.297 ↗
33. Finite element evaluations of the mechanical properties of polycaprolactone/hydroxyapatite scaffolds by direct ink writing: effects of pore geometry10.1016/j.jmbbm.2020.103665 ↗
34. High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing10.1007/s40145-020-0415-4 ↗
35. SLA 3D printing of high quality spine shaped β-TCP bioceramics for the hard tissue repair applications10.1016/j.ceramint.2019.11.261 ↗
36. Preparation of designed poly(d,l-lactide)/nanosized hydroxyapatite composite structures by stereolithography10.1016/j.actbio.2012.12.004 ↗
37. Shaping by microstereolithography and sintering of macro-microporous silicon substituted hydroxyapatite10.1016/j.jeurceramsoc.2015.11.020 ↗
38. 3D printing of hydroxyapatite scaffolds with good mechanical and biocompatible properties by digital light processing10.1007/s10853-018-1992-2 ↗
39. Additive manufacturing of hydroxyapatite bioceramic scaffolds: dispersion, digital light processing, sintering, mechanical properties, and biocompatibility10.1007/s40145-020-0375-8 ↗
40. A novel bone substitute with high bioactivity, strength, and porosity for repairing large and load-bearing bone defects10.1002/adhm.201801298 ↗
41. Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord
42. Pore size regulates mesenchymal stem cell response to Bioglass-loaded composite scaffolds10.1039/C5TB00947B ↗
43. The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering10.1016/j.biomaterials.2009.09.063 ↗
44. Techniques for fabrication and construction of three-dimensional bioceramic scaffolds: effect on pores size, porosity and compressive strength10.1016/j.ceramint.2018.07.056 ↗
45. Isotropic freeze casting of through-porous hydroxyapatite ceramics10.1007/s40145-018-0312-2 ↗
46. Organosilicon polymer-derived ceramics: an overview10.1007/s40145-019-0335-3 ↗
47. 3D gel-printing of hydroxyapatite scaffold for bone tissue engineering10.1016/j.ceramint.2018.09.300 ↗
48. Robust and nanostructured chitosan–silica hybrids for bone repair application10.1039/D0TB00009D ↗
49. A mineralized high strength and tough hydrogel for skull bone regeneration10.1002/adfm.201604327 ↗
50. SBF assays, direct and indirect cell culture tests to evaluate the biological performance of bioglasses and bioglass-based composites: three paradigmatic cases10.1016/j.msec.2018.12.006 ↗
51. In vitro degradability and apatite-formation ability of monticellite (CaMgSiO4) bioceramic10.1016/j.ceramint.2018.11.043 ↗
52. Current methodology of MTT assay in bacteria- A review10.1016/j.acthis.2018.03.007 ↗
53. Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition10.1038/s41598-018-19930-w ↗