Hydroxyapatite nanoparticle-enriched thiolated polymer-based biocompatible scaffold can improve skin tissue regeneration
Source abstract
Abstract
Hydroxyapatite has been extensively used in bone tissue regeneration but its application in skin tissue engineering and the underlying molecular mechanism remains unexplored. In the present study, we have developed a polymer hybrid scaffold functionalized with hydroxyapatite nanoparticles. Thiolated chitosan was combined with thiolated eudragit and polyethylene glycol to form the scaffold using the freeze–thawing technique. During the freeze–thawing process, the scaffolds were functionalized with hydroxyapatite nanoparticles. FTIR and XRD studies confirmed the polymeric interlinking in the scaffold during the freeze–thawing method. SEM and micro-CT analysis indicated the functionalization of the nanoparticle on the scaffold moiety and a spongy structure of the nanocomposite scaffold with controlled pore intensity. In silico study in corroboration with in vivo evaluation indicated that the component of the nanocomposite scaffold acts via controlling the actions of epidermal growth factor and glycogen synthase kinase and may prove to be a suitable material for tissue engineering.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Silk-based biomaterials and applications · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (60)
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