In situ formation of biohybrid system based on Streptococcus pneumoniae for enhanced radical therapy against tumors
Source abstract
Abstract
Clinical practices have shown that Streptococcus pneumoniae ( S. pn ) can induce severe lung injury by secreting amounts of hydrogen peroxide (H 2 O 2 ). Inspired by the reactive oxygen species (ROS)-mediated host-damaging characteristics of S. pn , we intended to apply S. pn for tumor therapy considering the heightened susceptibility of tumor cells to oxidative damage. However, the antitumor efficacy was not ideal due to the constrained oxidizing capacity of H 2 O 2 . To further improve the anti-tumor effect, we developed a biohybrid system (BHS) to equip S. pn with ferroferric oxide (Fe 3 O 4 ) artificial enzymes via click chemistry in tumor in situ , facilitating the conversion of bacteria-derived H 2 O 2 into highly active hydroxyl radicals (⋅OH) for enhanced tumor radical therapy even in a highly hypoxic pancreatic tumor model. The in situ -formed S. pn -based biohybrid system opens up an avenue for the treatment of malignant tumors by utilizing the inherent tissue damage characteristic of pathogens.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cancer Research and Treatments · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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