journal article·2024-03Open access

AMGC is a multiple-task graph neutral network for epigenetic target profiling

Shukai Gu, Lingjie Bao, Yuwei Yang, Yihao Zhao, Henry Hoi Yee Tong, Liwei Liu, Huanxiang Liu, Tingjun Hou, Yu Kang

Cell Reports Physical Science· Volume 5· Issue 3

Abstract

Accurate prediction of ligand-protein interactions is crucial in the initial stages of drug development, especially when focusing on intricate epigenetic targets. This study proposes AMGC, an adaptive multi-task graph conventional network with contrastive learning to predict the inhibitory activities of small molecules against a panel of 67 epigenetic targets. The results show that AMGC outperforms classic molecular fingerprint-based machine learning models and other graph neutral network (GNN) variant-based models in terms of predictive and generalization abilities. Additionally, owing to the advantages of multi-task learning on small datasets, the AMGC approach is well suited for epigenetic target fishing and surpasses the state-of-the-art consensus model ETP. The interpretability of AMGC is verified by highlighting the key atoms in the ligand that interact with surrounding residues. To facilitate easy access, we develop a user-friendly online server for the epigenetic target fishing service.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Computational Drug Discovery Methods · Bioinformatics and Genomic Networks · Machine Learning in Materials Science

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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