AMGC is a multiple-task graph neutral network for epigenetic target profiling
Source abstract
Abstract
Accurate prediction of ligand-protein interactions is crucial in the initial stages of drug development, especially when focusing on intricate epigenetic targets. This study proposes AMGC, an adaptive multi-task graph conventional network with contrastive learning to predict the inhibitory activities of small molecules against a panel of 67 epigenetic targets. The results show that AMGC outperforms classic molecular fingerprint-based machine learning models and other graph neutral network (GNN) variant-based models in terms of predictive and generalization abilities. Additionally, owing to the advantages of multi-task learning on small datasets, the AMGC approach is well suited for epigenetic target fishing and surpasses the state-of-the-art consensus model ETP. The interpretability of AMGC is verified by highlighting the key atoms in the ligand that interact with surrounding residues. To facilitate easy access, we develop a user-friendly online server for the epigenetic target fishing service.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Computational Drug Discovery Methods · Bioinformatics and Genomic Networks · Machine Learning in Materials Science
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (49)
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