In situ manufacture of hydrogel lubrication coating on damaged tissue to resist adhesion
Source abstract
Abstract
The human body involves many soft interfaces with excellent hydration and lubrication properties to resist biological adhesion. The abdominal cavity, one of the most important parts of soft tissues, commonly generates severe wear and adhesion-related complication upon encountering lubrication failure between the internal organs of the abdominal cavity and the abdominal wall. Here, we report a method for the manufacture of UV-cured hydrogel lubrication coating on damaged cecum tissue. The hydrogel coating consists of methacrylated carboxymethyl chitosan (MA-CMC) and o -nitrobenzene-grafted hyaluronic acid (HA-NB). The coating not only exhibits fast curing time, good bonding strength, as well as matching mechanics with organs but also shows good lubricity and anti-fouling properties. The anti-adhesion performance of the coating is verified in a constructed rat cecum-abdominal wall postoperative adhesion model. The current concept of hydrogel lubrication coating may help accelerate the development and clinical application of soft anti-adhesion materials.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Surgical Sutures and Adhesives · Hemostasis and retained surgical items · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (44)
Show source-provided references
1. Molecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins10.1016/j.cocis.2010.07.002 ↗
2. Oligolamellar lubrication of joints by surface active phospholipid
3. Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein10.1529/biophysj.106.088799 ↗
4. Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues10.1016/j.biomaterials.2018.07.040 ↗
5. Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels10.1021/accountsmr.1c00219 ↗
6. Recent Progress in Cartilage Lubrication10.1002/adma.202005513 ↗
7. The Diagnosis and Management of Dry Eye: A Twenty-five–Year Review10.1097/00003226-200009000-00009 ↗
8. Toward mucoadhesive hydrogel formulations for the management of xerostomia: the physicochemical, biological, and pharmacological considerations10.1002/jbm.a.34626 ↗
9. Rheologic behavior of osteoarthritic synovial fluid after addition of hyaluronic acid: a pilot study10.1007/s11999-009-0867-x ↗
10. Post-operative adhesions after digestive surgery: their incidence and prevention: review of the literature10.1016/j.jviscsurg.2011.11.006 ↗
11. The enhanced anti-tissue adhesive effect of injectable pluronic-HA hydrogel by poly(γ-glutamic acid)10.1016/j.ijbiomac.2016.02.064 ↗
12. Effect of hyaluronic acid on the excursion resistance of tendon graft: a biomechanical in vitro study in a modified human model10.1016/j.clinbiomech.2006.04.007 ↗
13. Cross-linked electrospun cartilage acellular matrix/poly(caprolactone-co-lactide-co-glycolide) nanofiber as an antiadhesive barrier10.1016/j.actbio.2018.05.032 ↗
14. An injectable and antifouling self-fused supramolecular hydrogel for preventing postoperative and recurrent adhesions10.1016/j.cej.2020.127096 ↗
15. An Ultrasoft Self-Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion10.1002/adma.202008395 ↗
16. Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion10.1073/pnas.2012491117 ↗
17. In-situ growth of robust superlubricated nano-skin on electrospun nanofibers for post-operative adhesion prevention10.1038/s41467-022-32804-0 ↗
18. Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion
19. An overview of functional biolubricants10.1007/s40544-022-0607-8 ↗
20. Functional hydrogel coatings10.1093/nsr/nwaa254 ↗
21. Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing10.1126/sciadv.adc9375 ↗
22. Pollen-Inspired Shell-Core Aerosol Particles Capable of Brownian Motion for Pulmonary Vascularization
23. Rapid fabrication of physically robust hydrogels10.1038/s41563-023-01648-4 ↗
24. Haemostatic materials for wound healing applications10.1038/s41570-021-00323-z ↗
25. Emerging hemostatic materials for non-compressible hemorrhage control10.1093/nsr/nwac162 ↗
26. (Bio)molecular surface patterning by phototriggered oxime ligation10.1002/anie.201202684 ↗
27. Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction10.1002/adma.201505336 ↗
28. A postoperative anti-adhesion barrier based on photoinduced imine-crosslinking hydrogel with tissue-adhesive ability10.1016/j.actbio.2017.08.047 ↗
29. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds10.1038/s41467-019-10004-7 ↗
30. Study of double-bonded carboxymethyl chitosan/cysteamine-modified chondroitin sulfate composite dressing for hemostatic application10.1016/j.eurpolymj.2021.110875 ↗
31. Hydrogel bioelectronics10.1039/C8CS00595H ↗
32. Postoperative adhesion formation and the use of adhesion preventing techniques in cardiac and general surgery
33. Post-Operative Adhesions: A Comprehensive Review of Mechanisms10.3390/biomedicines9080867 ↗
34. Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion
35. A review: progress in preventing tissue adhesions from a biomaterial perspective10.1039/D0BM02023K ↗
36. The histophysiology and pathophysiology of the peritoneum10.1016/j.tice.2016.11.004 ↗
37. The biology of adhesion formation in the peritoneal cavity10.1053/j.sempedsurg.2014.06.004 ↗
38. Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms10.3390/biom11050692 ↗
39. Inflammation in wound repair: molecular and cellular mechanisms10.1038/sj.jid.5700701 ↗
40. Effects of hypoxia on the expression of inflammatory markers IL-6 and TNF-a in human normal peritoneal and adhesion fibroblasts10.3109/19396368.2012.713439 ↗
41. TGF-beta system: the principal profibrotic mediator of peritoneal adhesion formation10.1055/s-0028-1082388 ↗
42. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice10.1096/fj.201600871RR ↗
43. Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery10.1016/j.surg.2012.07.037 ↗
44. Improving intraperitoneal chemotherapeutic effect and preventing postsurgical adhesions simultaneously with biodegradable micelles10.1016/j.nano.2011.10.010 ↗