Bioelectronic interfacial matching for superior implant design

Bioelectronics offer unprecedented spatiotemporal resolution in medicine, opening new doors to electronic therapies and monitoring systems. However, the development of bioelectronic medicine requires the construction of a stable interface between a device and tissue. Here, we focus on generating a framework from which to view this interface, specifically for the case of bioelectronic implants. We discuss general criteria that are important to consider when constructing a bioelectronic implant, with a major focus on the structure of the interface as it pertains to tissue. We categorize different mechanical, electrical, and chemical strategies that can be considered in tandem when designing a bioelectronic interface. This perspective aims to provide a useful framework to consider interfacial construction to aid in the development of new areas of bioelectronic medicine using implantable devices.