A critical review of palladium organometallic anticancer agents
Source abstract
Abstract
With the aim of overcoming the well-known limitations of platinum-based antineoplastic drugs, recent efforts have focused on the development of new anticancer agents containing metals other than platinum. Among these agents, organopalladium compounds have received significant recent attention due to their generally high stability under physiological conditions. A significant number of these compounds have shown promising in vitro and in vivo antiproliferative activity toward several cisplatin-sensitive and cisplatin-resistant tumors and have sometimes exhibited a different mechanism of action compared to platinum-based drugs. In this review, recent advances in the field of organopalladium compounds as potential anticancer agents are discussed.
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Research context
OpenAlex topics: Metal complexes synthesis and properties · Organometallic Complex Synthesis and Catalysis · N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. 2020
2. Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches10.2174/0929867054637626 ↗
3. Direct cellular responses to platinum-induced DNA damage10.1021/cr068207j ↗
4. Ruthenium complexes as anticancer agents: a brief history and perspectives10.2147/DDDT.S275007 ↗
5. Recent progress in polynuclear ruthenium complex-based DNA binders/structural probes and anticancer agents10.2174/0929867326666181203143422 ↗
6. Recent advances in gold-NHC complexes with biological properties10.1039/C8CS00570B ↗
7. Dinuclear gold(i) complexes: from bonding to applications10.1039/D0CS00438C ↗
8. Casini · 2019
9. Platinum, palladium, gold and ruthenium complexes as anticancer agents: current clinical uses, cytotoxicity studies and future perspectives10.1016/j.ejmech.2017.04.007 ↗
10. Anticancer activity of palladium-based complexes against triple-negative breast cancer10.1016/j.drudis.2019.02.012 ↗
11. Metabolic Aspects of Palladium(II) Potential Anti-Cancer Drugs10.3389/fonc.2020.590970 ↗
12. Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes10.1039/C4CS00063C ↗
13. Cyclopalladated and cycloplatinated benzophenone imines: antitumor, antibacterial and antioxidant activities, DNA interaction and cathepsin B inhibition10.1016/j.jinorgbio.2014.07.001 ↗
14. Cyclopalladated Benzophenone Imines: Synthesis, Antitumor Activity, Cell Accumulation, DNA Interaction, and Cathepsin B Inhibition10.1021/om501060f ↗
15. Endo and exo cyclopalladated (E)-N-([1,1′-biphenyl]-2-yl)-1- mesitylmethanimines: anticancer, antibacterial and antioxidant activities10.1016/j.jorganchem.2017.04.002 ↗
16. A new family of oxime palladacycles mixed with unsymmetrical phosphorus ylides; synthesis, structural, cytotoxicity and catalytic activity studies10.1016/j.jorganchem.2019.120927 ↗
17. para metallation of 3-acetyl-chromen-2-one Schiff bases in tetranuclear palladacycles: focus on their biomolecular interaction and in vitro cytotoxicity10.1039/C9DT02663K ↗
18. Synthesis, electronic structure and molecular docking of new organometallic palladium (II) complexes with intercalator ligands: the influence of bridged ligands on enhanced DNA/serum protein binding and in vitro antitumoral activity10.1016/j.jorganchem.2016.10.001 ↗
19. In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA10.1016/j.ejmech.2013.11.042 ↗
20. The biphosphinic paladacycle complex induces melanoma cell death through lysosomal-mitochondrial axis modulation and impaired autophagy10.1016/j.ejmech.2015.11.008 ↗
21. Cyclopalladated compounds as chemotherapeutic agents: antitumor activity against a murine melanoma cell line10.1002/ijc.11434 ↗
22. Synthesis and characterization of planar chiral cyclopalladated ferrocenylimines: DNA/HSA interactions and in vitro cytotoxic activity10.1016/j.jorganchem.2018.06.027 ↗
23. Organometallic binuclear Pd(II) complex: synthesis, crystal structure and in-vitro antitumor activity study10.1016/j.inoche.2019.05.017 ↗
24. A novel cyclopalladated ferrocene derivative: synthesis, single crystal structure and evaluation of in vitro antitumor activity10.1016/j.molstruc.2019.127077 ↗
25. Synthesis, characterization and biological activities of two novel orthopalladated complexes: interactions with DNA and bovine serum albumin, antitumour activity and molecular docking studies10.1002/aoc.3740 ↗
26. Synthesis and spectroscopic characterization study of new palladium complexes containing bioactive O,O-chelated ligands: evaluation of the DNA/protein BSA interaction, in vitro antitumoural activity and molecular docking10.1080/07391102.2017.1391125 ↗
27. Synthesis, spectroscopic characterization and in vitro cytotoxicities of new organometallic palladium complexes with biologically active β-diketones; biological evaluation probing of the interaction mechanism with DNA/protein and molecular docking10.1016/j.molstruc.2017.10.059 ↗
28. Synthesis, characterization and molecular docking of new C,N-palladacycles containing pyridinium-derived ligands: DNA and BSA interaction studies and evaluation as antitumor agents10.1002/aoc.4728 ↗
29. Spectral and molecular docking studies of nucleic acids/protein binding interactions of a novel organometallic palladium (II) complex containing bioactive PTA ligands: its synthesis, anticancer effects and encapsulation in albumin nanoparticles10.1002/aoc.5839 ↗
30. New Pd/Pt(II) complexes as unsymmetrical ylide-based chemotherapeutic agents: synthesis, characterization, biological activity, electrochemical, and X-ray studies10.1039/C8NJ00797G ↗
31. Different properties of P,C-donor Pd(II) and Pt(II); spectroscopic and X-ray analysis, catalytic potential and anti-proliferative potency10.1016/j.jorganchem.2019.03.002 ↗
32. Synthesis, characterization, theoretical and cytotoxicity studies of Pd(II) and Pt(II) complexes with new bidentate carbon donor ligand10.1016/j.poly.2019.01.016 ↗
33. Synthesis and characterization of palladacyclopentadiene complexes with N-heterocyclic carbene ligands10.1016/j.jorganchem.2015.07.014 ↗
34. Catalytic Three-Component Synthesis of Conjugated Dienes from Alkynes via Pd0, PdII and PdIV Intermediates Containing 1,2-Diimine10.1002/anie.199717431 ↗
35. The addition of bromine and iodine to palladacyclopentadienyl complexes bearing bidentate heteroditopic P-N spectator ligands derived from differently substituted quinolinic frames. The unexpected evolution of the reaction10.1039/C5DT01884F ↗
36. The unexpected case of reactions of halogens and interhalogens with halide substituted Pd(ii) σ-butadienyl complexes10.1039/C6DT01964A ↗
37. Addition of halogens and interhalogens on palladacyclopentadienyl complexes stabilized by pyridyl−thioether N−S spectator ligands10.1016/j.jorganchem.2016.02.011 ↗
38. The addition of halogens and interhalogens on palladacyclopentadienyl complexes bearing quinolyl-thioether as spectator ligands. A kinetic and computational study10.1016/j.poly.2016.04.008 ↗
39. Bioconjugates of enantiomerically pure organopalladium compounds by metal-assisted positional selective transesterifications at palladium enolates10.1002/chem.201003308 ↗
40. Palladacyclopentadienyl complexes bearing purine-based N-heterocyclic carbenes: a new class of promising antiproliferative agents against human ovarian cancer10.1002/aoc.4902 ↗
41. A categorization of metal anticancer compounds based on their mode of action10.1039/b905798f ↗
42. Synthesis and in-depth studies on the anticancer activity of novel palladacyclopentadienyl complexes stabilized by N-heterocyclic carbene ligands10.1016/j.ejmech.2019.06.065 ↗
43. Reactivity of N-heterocyclic carbene-pyridine palladacyclopentadiene complexes toward halogen addition. The unpredictable course of the reaction10.1039/C7DT02162C ↗
44. Improved Synthesis, Anticancer Activity and Electrochemical Characterization of Unusual Zwitterionic Palladium Compounds with a Ten-Term Coordinative Ring10.1002/slct.201902316 ↗
45. Extending the Application Scope of Organophosphorus(V) Compounds in Palladium(II) Pincer Chemistry10.1021/acs.organomet.8b00867 ↗
46. The two isomers of a cyclometallated palladium sensitizer show different photodynamic properties in cancer cells10.1039/C8CC10134E ↗
47. The Self-Assembly of a Cyclometalated Palladium Photosensitizer into Protein-Stabilized Nanorods Triggers Drug Uptake In Vitro and In Vivo10.1021/jacs.0c01369 ↗
48. An overview of N-heterocyclic carbenes10.1038/nature13384 ↗
49. Synthetic Routes to Late Transition Metal–NHC Complexes10.1016/j.trechm.2020.06.001 ↗
50. N-Heterocyclic Carbene Complexes in C-H Activation Reactions10.1021/acs.chemrev.9b00634 ↗
51. N-Heterocyclic Carbenes in Materials Chemistry10.1021/acs.chemrev.8b00514 ↗
52. Metal N-heterocyclic carbene complexes in medicinal chemistry10.1016/bs.adioch.2019.10.008 ↗
53. Cyclometalated Palladium(II) N-Heterocyclic Carbene Complexes: Anticancer Agents for Potent In Vitro Cytotoxicity and In Vivo Tumor Growth Suppression10.1002/anie.201602814 ↗
54. Palladium complexes of bidentate pyridine N-heterocyclic carbenes: optical resolution, antimicrobial and cytotoxicity studies10.1002/aoc.4377 ↗
55. Palladium Complexes with Tridentate N-Heterocyclic Carbene Ligands: Selective “Normal” and “Abnormal” Bindings and Their Anticancer Activities10.1021/acs.organomet.5b00586 ↗
56. Water soluble palladium(II) and platinum(II) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity10.1039/D0NJ00060D ↗
57. Macrocyclic NHC complexes of group 10 elements with enlarged aromaticity for biological studies10.1039/D0DT02598D ↗
58. The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer10.1039/D0CC03883K ↗
59. Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes10.1021/ja075889z ↗
60. Sterically tuned Ag(I)- and Pd(II)-N-heterocyclic carbene complexes of imidazol-2-ylidenes: synthesis, crystal structures, and in vitro antibacterial and anticancer studies10.1039/c3mt00051f ↗
61. Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: synthesis, structural and in vitro anticancer activity10.5155/eurjchem.7.1.115-120.1387 ↗
62. Mono- and bis-N-heterocyclic carbene silver(I) and palladium(II) complexes: synthesis, characterization, crystal structure and in vitro anticancer studies10.1016/j.poly.2016.09.065 ↗
63. Investigation of structural and biological properties of N-heterocyclic carbene silver(I) and palladium(II) complexes10.1080/00958972.2018.1511050 ↗
64. Synthesis, characterization, crystal structure and in vitro anticancer potentials of mono and bimetallic palladium(II)–N–heterocyclic carbene complexes10.1016/j.inoche.2016.11.014 ↗
65. Synthesis, structures and anticancer studies of symmetrically and non-symmetrically aliphatic nitrile functionalized silver(I)-N-heterocyclic carbene and palladium(II)-N-heterocyclic carbene complexes10.1080/24701556.2018.1504074 ↗
66. Palladium(II) N-heterocyclic carbene complexes: synthesis, structures and cytotoxicity potential studies against breast cancer cell line10.1080/00958972.2018.1485901 ↗
67. Potent Anticancer Activity with High Selectivity of a Chiral Palladium N-Heterocyclic Carbene Complex10.1021/acsomega.7b00688 ↗
68. Kumar · 2019
69. In vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium salts10.1016/j.ica.2016.05.001 ↗
70. New compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines10.1016/j.jorganchem.2017.03.037 ↗
71. Antiproliferative activities of 2-hydroxyethyl substituted benzimidazolium salts and their palladium complexes against human cancerous cell lines
72. New Water-Soluble N-Heterocyclic Carbene-Palladium Complexes as Promising Anti-Tumor Agents: Investigating DNA and Protein Interactions10.1002/slct.201800535 ↗
73. Palladium(II) and ruthenium(II) complexes of benzotriazole functionalized N-heterocyclic carbenes: cytotoxicity, antimicrobial, and DNA interaction studies10.1016/j.jorganchem.2019.02.013 ↗
74. Preparation and characterization of PEPPSI-palladium N-heterocyclic carbene complexes using benzimidazolium salts catalyzed Suzuki–Miyaura cross coupling reaction and their antitumor and antimicrobial activities10.1080/00958972.2019.1572886 ↗
75. Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents10.3390/catal10101190 ↗
76. Novel cis-[PdCl2(NHC)(PPh3)] complex: synthesis, crystal structure, spectral investigations, DFT and NCI studies, prediction of biological activity10.1080/00958972.2020.1732360 ↗
77. N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity10.1021/acsomega.8b02387 ↗
78. New palladium(II) and platinum(II) complexes with the model nucleobase 1-methylcytosine: antitumor activity and interactions with DNA10.1021/ic0502372 ↗
79. The cytotoxic and growth inhibitory effects of palladium(II) complexes on MDA-MB-435 cells10.1590/S1415-47572012005000016 ↗
80. Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes10.1039/C7DT04615D ↗
81. Palladium(II) Acetylide Complexes with Pincer-Type Ligands: Photophysical Properties, Intermolecular Interactions, and Photo-cytotoxicity10.1002/asia.201601414 ↗
82. Crabtree · 2014 · 134
83. Chemoselective oxidative addition of vinyl sulfones mediated by palladium complexes bearing picolyl-N-heterocyclic carbene ligands10.1039/D0DT01144D ↗
84. Reactions of palladium(0) olefin complexes stabilized by some different hetero- and homo-ditopic spectator ligands with propargyl halides10.1016/j.jorganchem.2017.02.003 ↗
85. Oxidative addition of organic halides on palladium(0) complexes stabilized by dimethylfumarate and quinoline-based N–P or N–S spectator ligands10.1016/j.poly.2015.07.049 ↗
86. Synthesis of novel olefin complexes of palladium(0) bearing monodentate NHC, phosphine and isocyanide spectator ligands10.1016/j.poly.2018.01.010 ↗
87. Synthesis and characterization of novel olefin complexes of palladium(0) with chelating bis(N-heterocyclic carbenes) as spectator ligands10.1016/j.poly.2018.08.007 ↗
88. Oxidative addition of allyl and propargyl halides on palladium(0) complexes bearing bidentate ligands with quinolinic structure10.1016/j.jorganchem.2015.01.023 ↗
89. Synthesis of palladium(0) and -(II) complexes with chelating bis(N-heterocyclic carbene) ligands and their application in semihydrogenation10.1039/c3dt32835j ↗
90. Measuring the Olefin-to-Pd(0) Bond Strength: A Kinetic Study Involving Olefin Exchange Reactions on Palladium(0) Complexes Bearing Isocyanide Ligands10.1002/hlca.202000150 ↗
91. The importance of the electronic and steric features of the ancillary ligands on the rate of cis–trans isomerization of olefins coordinated to palladium(0) centre. A study involving (Z)-1,2-ditosylethene as olefin model10.1016/j.poly.2019.114144 ↗
92. Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo10.1158/1078-0432.CCR-08-0405 ↗
93. Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells10.3109/10428194.2016.1161186 ↗
94. Tris DBA palladium overcomes hypoxia-mediated drug resistance in multiple myeloma10.3109/10428194.2015.1099645 ↗
95. New Pd/Pt-[60]fullerene complexes of phosphorus ylides as anticancer agents: Cytotoxic investigation and DFT calculations10.1016/j.jorganchem.2018.02.013 ↗
96. Palladium (0) olefin complexes bearing purine-based N-heterocyclic carbenes and 1,3,5-triaza-7-phosphaadamantane (PTA): synthesis, characterization and antiproliferative activity toward human ovarian cancer cell lines10.1016/j.jorganchem.2019.07.008 ↗
97. Synthesis, spectral characterization of novel Pd(II), Pt(II) π-coordination compounds based on N-allylthioureas. Cytotoxic properties and DNA binding ability10.1016/j.jinorgbio.2016.12.004 ↗
98. 2-Methyltetrahydrofuran (2-MeTHF): A Green Solvent for Pd−NHC-Catalyzed Amide and Ester Suzuki-Miyaura Cross-Coupling by N−C/O−C Cleavage10.1002/adsc.201901188 ↗
99. Synthesis of novel allyl palladium complexes bearing purine based NHC and a water soluble phosphine and their catalytic activity in the Suzuki-Miyaura coupling in water10.1002/aoc.4034 ↗
100. Synthesis of Di-Substituted Alkynes via Palladium-Catalyzed Decarboxylative Coupling and C-H Activation10.1002/slct.201803805 ↗