Development of Cryogenic Electrohydrodynamic Jet Printing for Fabrication of Fine Scaffolds with Extra Filament Surface Topography

Electrohydrodynamic jet printing (EJP) is a developing additive manufacture technology that enables the fabrication of fine scaffolds directly from polymer solutions or melt. Timely solidification of the polymer jet is the key factor for the success of EJP process. In conventional solution-based EJP methods, it is usually achieved by rapid solvent evaporation and producing a scaffold with smooth filaments. In current study, by combining solution-based EJP with a cryogenic workbench, a cryogenic electrohydrodynamic jet printing (CEJP) system was developed, in which the polymer jet was frozen and solidified quickly at the freezing temperature rather than solvent evaporation. The feasibility and versatility of the CEJP system were verified by successful printing of scaffolds with different hole shapes and pore sizes. Meanwhile, the resulting scaffolds not only had a resolution in the range of 50–80 μm but also possessed oriented “ridges” and “valleys” on surface of the filaments, which was conductive to cell orientation. Therefore, this work provides a novel method to print fine scaffolds with extra surface topography.