Synthesis, applications in therapeutics, and bioimaging of traditional Chinese medicine-derived carbon dots
Source abstract
Abstract
Carbon dots (CDs) are a novel type of fluorescent nanoparticles with a particle size smaller than 10 nm. They possess several advantageous properties, including excellent biocompatibility, light stability, water solubility, and low toxicity. CDs have been widely researched in recent years. As a treasure of ancient Chinese science, traditional Chinese medicine (TCM) is rich in various active ingredients and has a variety of pharmacodynamic effects, which have been used for thousands of years. TCM-CDs prepared with TCM as carbon source can create some special functions and then may play a greater medicinal value. The purpose of this review was to engage in an in-depth conversation about the use of TCM-CDs in medical therapy and bioimaging. Firstly, this study provides a comprehensive exploration of different synthesis methods for TCM-CDs, comparing their respective advantages and disadvantages. Subsequently, the intrinsic pharmacological activity of TCM-CDs, encompassing antibacterial, hypoglycemic, hemostatic, anticancer, and anti-inflammatory effects, is mainly discussed, alongside their underlying mechanisms of action. Additionally, investigations into in vitro imaging of diverse cell types and the distribution and uptake of TCM-CDs under in vivo imaging guidance are presented. Finally, the significance of TCM-CD research, key challenges and issues within this field, and future directions for development are summarized and outlined. Graphical abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Heavy Metal Exposure and Toxicity · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Jadidi Kouhbanani MA, Mosleh-Shirazi S, Beheshtkhoo N, Kasaee SR, Nekouian S, Alshehery S, Kamyab H, Chelliapan S, Ali MA, Amani AM (2023) Investigation through the antimicrobial activity of electrospun PCL nanofiber mats with green synthesized Ag–Fe nanoparticles. J Drug Deliv Sci Technol 85:10454110.1016/j.jddst.2023.104541 ↗
2. Kamyab H, Chelliapan S, Hayder G, Yusuf M, Taheri MM, Rezania S, Hasan M, Yadav KK, Khorami M, Farajnezhad M, Nouri J (2023) Exploring the potential of metal and metal oxide nanomaterials for sustainable water and wastewater treatment: a review of their antimicrobial properties. Chemosphere 335:13910310.1016/j.chemosphere.2023.139103 ↗
3. Chandra S, Singh VK, Yadav PK, Bano D, Kumar V, Pandey VK, Talat M, Hasan SH (2019) Mustard seeds derived fluorescent carbon quantum dots and their peroxidase-like activity for colorimetric detection of H(2)O(2) and ascorbic acid in a real sample. Anal Chim Acta 1054:145–15610.1016/j.aca.2018.12.024 ↗
4. Chenghao L, Yamin L, Bin L, Ulla S, Xianyan R, Yaping S (2022) Toward high-performance and functionalized carbon dots: strategies, features, and prospects. Prog Chem 34:499
5. Huang Q, Li Q, Chen Y, Tong L, Lin X, Zhu J, Tong Q (2018) High quantum yield nitrogen-doped carbon dots: green synthesis and application as “off-on” fluorescent sensors for the determination of Fe3+ and adenosine triphosphate in biological samples. Sens Actuators B Chem 276:82–8810.1016/j.snb.2018.08.089 ↗
6. Ben-Zichri S, Rajendran S, Bhunia SK, Jelinek R (2022) Resveratrol carbon dots disrupt mitochondrial function in cancer cells. Bioconjug Chem 33(9):1663–167110.1021/acs.bioconjchem.2c00282 ↗
7. Mosleh-Shirazi S, Kasaee SR, Dehghani F, Kamyab H, Kirpichnikova I, Chelliapan S, Firuzyar T, Akhtari M, Amani AM (2023) Investigation through the anticancer properties of green synthesized spinel ferrite nanoparticles in present and absent of laser photothermal effect. Ceram Int 49(7):11293–1130110.1016/j.ceramint.2022.11.329 ↗
8. Tao J, Zou H, Liao X, Lu X, Cao J, Pan J, Li C, Zheng Y (2022) Fabrication of FA/HA-functionalized carbon dots for human breast cancer cell targeted imaging. Photodiagn Photodyn Ther 40:10309910.1016/j.pdpdt.2022.103099 ↗
9. Li S, Jiang J, Yan Y, Wang P, Huang G, Kim NH, Lee JH, He D (2018) Red, green, and blue fluorescent folate-receptor-targeting carbon dots for cervical cancer cellular and tissue imaging. Mater Sci Eng C Mater Biol Appl 93:1054–106310.1016/j.msec.2018.08.058 ↗
10. Bhunia SK, Maity AR, Nandi S, Stepensky D, Jelinek R (2016) Imaging cancer cells expressing the folate receptor with carbon dots produced from folic acid. ChemBioChem 17(7):614–61910.1002/cbic.201500694 ↗
11. Rao C, Khan S, Verma NC, Nandi CK (2017) Labelling proteins with carbon nanodots. ChemBioChem 18(24):2385–238910.1002/cbic.201700440 ↗
12. Unnikrishnan B, Wu RS, Wei SC, Huang CC, Chang HT (2020) Fluorescent carbon dots for selective labeling of subcellular organelles. ACS Omega 5(20):11248–1126110.1021/acsomega.9b04301 ↗
13. Gong X, Wang Z, Zhang L, Dong W, Wang R, Liu Y, Song S, Hu Q, Du F, Shuang S, Dong C (2022) A novel carbon-nanodots-based theranostic nano-drug delivery system for mitochondria-targeted imaging and glutathione-activated delivering camptothecin. Colloids Surf B Biointerfaces 218:11271210.1016/j.colsurfb.2022.112712 ↗
14. Wei J, Zhang X, Mugo SM, Zhang Q (2022) A portable sweat sensor based on carbon quantum dots for multiplex detection of cardiovascular health biomarkers. Anal Chem 94(37):12772–1278010.1021/acs.analchem.2c02587 ↗
15. Chen J, Yuan N, Jiang D, Lei Q, Liu B, Tang W, Row KH, Qiu H (2021) Octadecylamine and glucose-coderived hydrophobic carbon dots-modified porous silica for chromatographic separation. Chin Chem Lett 32(11):3398–340110.1016/j.cclet.2021.04.052 ↗
16. Egorova MN, Tomskaya AE, Kapitonov AN, Alekseev AA, Smagulova SA (2018) Hydrothermal synthesis of luminescent carbon dots from glucose and birch bark soot. J Struct Chem 59(4):780–78510.1134/S0022476618040054 ↗
17. Li D, Xu KY, Zhao WP, Liu MF, Feng R, Li DQ, Bai J, Du WL (2022) Chinese medicinal herb-derived carbon dots for common diseases: efficacies and potential mechanisms. Front Pharmacol 13:81547910.3389/fphar.2022.815479 ↗
18. Zhang J, Yu S-H (2016) Carbon dots: large-scale synthesis, sensing and bioimaging. Mater Today 19(7):382–39310.1016/j.mattod.2015.11.008 ↗
19. Wang Z, Liao H, Wu H, Wang B, Zhao H, Tan M (2015) Fluorescent carbon dots from beer for breast cancer cell imaging and drug delivery. Anal Methods 7(20):8911–891710.1039/C5AY01978H ↗
20. Liu J, Lu S, Tang Q, Zhang K, Yu W, Sun H, Yang B (2017) One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis. Nanoscale 9(21):7135–714210.1039/C7NR02128C ↗
21. Cui F, Ye Y, Ping J, Sun X (2020) Carbon dots: current advances in pathogenic bacteria monitoring and prospect applications. Biosens Bioelectron 156:11208510.1016/j.bios.2020.112085 ↗
22. Dong X, Liang W, Meziani MJ, Sun YP, Yang L (2020) Carbon dots as potent antimicrobial agents. Theranostics 10(2):671–68610.7150/thno.39863 ↗
23. Yang S, Sun J, Li X, Zhou W, Wang Z, He P, Ding G, Xie X, Kang Z, Jiang M (2014) Large-scale fabrication of heavy doped carbon quantum dots with tunable-photoluminescence and sensitive fluorescence detection. J Mater Chem A 2(23):8660–866710.1039/c4ta00860j ↗
24. Miao R, Meng Q, Wang C, Yuan W (2022) Bibliometric analysis of network pharmacology in traditional Chinese medicine. Evid Based Complement Altern Med 2022:158377310.1155/2022/1583773 ↗
25. Zhang Y, Wang S, Lu F, Zhang M, Kong H, Cheng J, Luo J, Zhao Y, Qu H (2021) The neuroprotective effect of pretreatment with carbon dots from Crinis Carbonisatus (carbonized human hair) against cerebral ischemia reperfusion injury. J Nanobiotechnol 19(1):25710.1186/s12951-021-00908-2 ↗
26. Wu D, Huang X, Deng X, Wang K, Liu Q (2013) Preparation of photoluminescent carbon nanodots by traditional Chinese medicine and application as a probe for Hg2+. Anal Methods 5(12):3023–302710.1039/c3ay40337h ↗
27. Chen J, Wang Y, Wang L, Liu M, Fang L, Chu P, Gao C, Chen D, Ren D, Zhang J (2023) Multi-applications of carbon dots and polydopamine-coated carbon dots for Fe(3+) detection, bioimaging, dopamine assay and photothermal therapy. Discov Nano 18(1):3010.1186/s11671-023-03809-5 ↗
28. Yu J, Song N, Zhang Y-K, Zhong S-X, Wang A-J, Chen J (2015) Green preparation of carbon dots by Jinhua bergamot for sensitive and selective fluorescent detection of Hg2+ and Fe3+. Sens Actuators B Chem 214:29–3510.1016/j.snb.2015.03.006 ↗
29. Zuo G, Xie A, Li J, Su T, Pan X, Dong W (2017) Large emission red-shift of carbon dots by fluorine doping and their applications for red cell imaging and sensitive intracellular Ag+ detection. J Phys Chem C 121(47):26558–2656510.1021/acs.jpcc.7b10179 ↗
30. Kumari M, Chaudhary GR, Chaudhary S, Umar A, Akbar S, Baskoutas S (2022) Bio-derived fluorescent carbon dots: synthesis, properties and applications. Molecules 27(16):532910.3390/molecules27165329 ↗
31. Tang S, Chen D, Guo G, Li X, Wang C, Li T, Wang G (2022) A smartphone-integrated optical sensing platform based on Lycium ruthenicum derived carbon dots for real-time detection of Ag+. Sci Total Environ 825:15391310.1016/j.scitotenv.2022.153913 ↗
32. Sun X, He J, Yang S, Zheng M, Wang Y, Ma S, Zheng H (2017) Green synthesis of carbon dots originated from Lycii Fructus for effective fluorescent sensing of ferric ion and multicolor cell imaging. J Photochem Photobiol B 175:219–22510.1016/j.jphotobiol.2017.08.035 ↗
33. Tian R, Guo Y, Luo F, Yang T, Zhou Z, Wang Z, Xie Y (2023) Green synthesis of multifunctional carbon dots from Crataegi Fructus for pH sensing, cell imaging and hemostatic effects. J Photochem Photobiol A: Chem 438:11453110.1016/j.jphotochem.2022.114531 ↗
34. Zheng X, Qin K, He L, Ding Y, Luo Q, Zhang C, Cui X, Tan Y, Li L, Wei Y (2021) Novel fluorescent nitrogen-doped carbon dots derived from Panax notoginseng for bioimaging and high selectivity detection of Cr6+. Analyst 146(3):911–91910.1039/D0AN01599G ↗
35. Jiang X, Liu X, Wu M, Ma Y, Xu X, Chen L, Niu N (2022) Facile off-on fluorescence biosensing of human papillomavirus using DNA probe coupled with sunflower seed shells carbon dots. Microchem J 181:10774210.1016/j.microc.2022.107742 ↗
36. Luo J, Zhang M, Cheng J, Wu S, Xiong W, Kong H, Zhao Y, Qu H (2018) Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata. RSC Adv 8(66):37707–3771410.1039/C8RA06340K ↗
37. Zhang M, Zhao Y, Cheng J, Liu X, Wang Y, Yan X, Zhang Y, Lu F, Wang Q, Qu H (2018) Novel carbon dots derived from Schizonepetae Herba Carbonisata and investigation of their haemostatic efficacy. Artif Cells Nanomed Biotechnol 46(8):1562–1571
38. Wang H, Zhang M, Ma Y, Wang B, Shao M, Huang H, Liu Y, Kang Z (2020) Selective inactivation of Gram-negative bacteria by carbon dots derived from natural biomass: Artemisia argyi leaves. J Mater Chem B 8(13):2666–267210.1039/C9TB02735A ↗
39. Leong CR, Tong WY, Tan W-N, Tumin ND, Yusof FAM, Yacob LS, bin Rosli MIH, Md Abu T (2020) Synthesis of curcumin quantum dots and their antimicrobial activity on necrotizing fasciitis causing bacteria. Mater Today: Proc 31:31–35
40. Qu X, Gao C, Fu L, Chu Y, Wang JH, Qiu H, Chen J (2023) Positively charged carbon dots with antibacterial and antioxidant dual activities for promoting infected wound healing. ACS Appl Mater Interfaces 15(15):18608–1861910.1021/acsami.2c21839 ↗
41. Wang X, Zhang Y, Kong H, Cheng J, Zhang M, Sun Z, Wang S, Liu J, Qu H, Zhao Y (2020) Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties. Artif Cells Nanomed Biotechnol 48(1):68–7610.1080/21691401.2019.1699810 ↗
42. Wei X, Li L, Liu J, Yu L, Li H, Cheng F, Yi X, He J, Li B (2019) Green synthesis of fluorescent carbon dots from gynostemma for bioimaging and antioxidant in zebrafish. ACS Appl Mater Interfaces 11(10):9832–984010.1021/acsami.9b00074 ↗
43. Li Y, Li W, Yang X, Kang Y, Zhang H, Liu Y, Lei B (2020) Salvia miltiorrhiza-derived carbon dots as scavengers of reactive oxygen species for reducing oxidative damage of plants. ACS Appl Nano Mater 4(1):113–12010.1021/acsanm.0c02419 ↗
44. Sharma V, Tiwari P, Mobin SM (2017) Sustainable carbon-dots: recent advances in green carbon dots for sensing and bioimaging. J Mater Chem B 5(45):8904–892410.1039/C7TB02484C ↗
45. Naik GG, Shah J, Balasubramaniam AK, Sahu AN (2021) Applications of natural product-derived carbon dots in cancer biology. Nanomedicine 16(7):587–60810.2217/nnm-2020-0424 ↗
46. Humaera NA, Fahri AN, Armynah B, Tahir D (2021) Natural source of carbon dots from part of a plant and its applications: a review. Luminescence 36(6):1354–136410.1002/bio.4084 ↗
47. Wu X, Liang W, Cai C (2021) Photoluminescence mechanisms of carbon quantum dots. Prog Chem 33:1059
48. Wang B, Song H, Qu X, Chang J, Yang B, Lu S (2021) Carbon dots as a new class of nanomedicines: opportunities and challenges. Coord Chem Rev 442:21401010.1016/j.ccr.2021.214010 ↗
49. Meng W, Bai X, Wang B, Liu Z, Lu S, Yang B (2019) Biomass-derived carbon dots and their applications. Energy Environ Mater 2(3):172–19210.1002/eem2.12038 ↗
50. Tuerhong M, Xu Y, Yin X-B (2017) Review on carbon dots and their applications. Chin J Anal Chem 45(1):139–15010.1016/S1872-2040(16)60990-8 ↗
51. Sagbas S, Sahiner N (2019) Carbon dots: preparation, properties, and application. In: Nanocarbon and its composites, pp 651–67610.1016/B978-0-08-102509-3.00022-5 ↗
52. Wang Y, Hu A (2014) Carbon quantum dots: synthesis, properties and applications. J Mater Chem C 2(34):6921–693910.1039/C4TC00988F ↗
53. Meng W, Wang B, Ai L, Song H, Lu S (2021) Engineering white light-emitting diodes with high color rendering index from biomass carbonized polymer dots. J Colloid Interface Sci 598:274–28210.1016/j.jcis.2021.04.022 ↗
54. Namdari P, Negahdari B, Eatemadi A (2017) Synthesis, properties and biomedical applications of carbon-based quantum dots: an updated review. Biomed Pharmacother 87:209–22210.1016/j.biopha.2016.12.108 ↗
55. Chandra S, Bano D, Pradhan P, Singh VK, Yadav PK, Sinha D, Hasan SH (2020) Nitrogen/sulfur-co-doped carbon quantum dots: a biocompatible material for the selective detection of picric acid in aqueous solution and living cells. Anal Bioanal Chem 412(15):3753–376310.1007/s00216-020-02629-1 ↗
56. Yang X, Liu M, Yin Y, Tang F, Xu H, Liao X (2018) Green, hydrothermal synthesis of fluorescent carbon nanodots from gardenia, enabling the detection of metronidazole in pharmaceuticals and rabbit plasma. Sensors (Basel) 18(4):96410.3390/s18040964 ↗
57. Asha Jhonsi M, Kathiravan A (2017) Photoinduced interaction of arylamine dye with carbon quantum dots ensued from Centella asiatica. J Lumin 192:321–32710.1016/j.jlumin.2017.06.056 ↗
58. Suvarnaphaet P, Tiwary CS, Wetcharungsri J, Porntheeraphat S, Hoonsawat R, Ajayan PM, Tang IM, Asanithi P (2016) Blue photoluminescent carbon nanodots from limeade. Mater Sci Eng C Mater Biol Appl 69:914–92110.1016/j.msec.2016.07.075 ↗
59. Dager A, Uchida T, Maekawa T, Tachibana M (2019) Synthesis and characterization of mono-disperse carbon quantum dots from fennel seeds: photoluminescence analysis using machine learning. Sci Rep 9(1):1400410.1038/s41598-019-50397-5 ↗
60. Liu X, Wang T, Wang W, Zhou Z, Yan Y (2019) A tailored molecular imprinting ratiometric fluorescent sensor based on red/blue carbon dots for ultrasensitive tetracycline detection. J Ind Eng Chem 72:100–10610.1016/j.jiec.2018.12.007 ↗
61. Zhang W, Chen J, Gu J, Bartoli M, Domena JB, Zhou Y, Ferreira BCLB, Cilingir EK, McGee CM, Sampson R, Arduino C, Tagliaferro A, Leblanc RM (2023) Nano-carrier for gene delivery and bioimaging based on pentaethylenehexamine modified carbon dots. J Colloid Interface Sci 639:180–19210.1016/j.jcis.2023.02.046 ↗
62. Thokchom B, Bhavi SM, Abbigeri MB, Shettar AK, Yarajarla RB (2023) Green synthesis, characterization and biomedical applications of Centella asiatica-derived carbon dots. Carbon Lett 33(4):1057–107110.1007/s42823-023-00505-3 ↗
63. Li W, Wang S, Li Y, Ma C, Huang Z, Wang C, Li J, Chen Z, Liu S (2017) One-step hydrothermal synthesis of fluorescent nanocrystalline cellulose/carbon dot hydrogels. Carbohydr Polym 175:7–1710.1016/j.carbpol.2017.07.062 ↗
64. Tejwan N, Saha SK, Das J (2020) Multifaceted applications of green carbon dots synthesized from renewable sources. Adv Colloid Interface Sci 275:10204610.1016/j.cis.2019.102046 ↗
65. Rong M, Wang D, Li Y, Zhang Y, Huang H, Liu R, Deng X (2021) Green-emitting carbon dots as fluorescent probe for nitrite detection. J Anal Test 5(1):51–5910.1007/s41664-021-00161-4 ↗
66. Li CL, Ou CM, Huang CC, Wu WC, Chen YP, Lin TE, Ho LC, Wang CW, Shih CC, Zhou HC, Lee YC, Tzeng WF, Chiou TJ, Chu ST, Cang J, Chang HT (2014) Carbon dots prepared from ginger exhibiting efficient inhibition of human hepatocellular carcinoma cells. J Mater Chem B 2(28):4564–457110.1039/c4tb00216d ↗
67. Zhu S, Meng Q, Wang L, Zhang J, Song Y, Jin H, Zhang K, Sun H, Wang H, Yang B (2013) Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging. Angew Chem Int Ed Engl 52(14):3953–395710.1002/anie.201300519 ↗
68. Yuan F, Wang Z, Li X, Li Y, Tan Z, Fan L, Yang S (2017) Bright multicolor bandgap fluorescent carbon quantum dots for electroluminescent light-emitting diodes. Adv Mater 29(3):160443610.1002/adma.201604436 ↗
69. Shen Y, Wu H, Wu W, Zhou L, Dai Z, Dong S (2020) A facile hydrothermal method to synthesize fluorescent carbon dots for detecting iron. Mater Express 10(7):1135–114010.1166/mex.2020.1745 ↗
70. Zhao X, Liao S, Wang L, Liu Q, Chen X (2019) Facile green and one-pot synthesis of purple perilla derived carbon quantum dot as a fluorescent sensor for silver ion. Talanta 201:1–810.1016/j.talanta.2019.03.095 ↗
71. Atchudan R, Edison TNJI, Aseer KR, Perumal S, Lee YR (2018) Hydrothermal conversion of Magnolia liliiflora into nitrogen-doped carbon dots as an effective turn-off fluorescence sensing, multi-colour cell imaging and fluorescent ink. Colloids Surf B 169:321–32810.1016/j.colsurfb.2018.05.032 ↗
72. Wang S, Wu S-H, Fang W-L, Guo X-F, Wang H (2019) Synthesis of non-doped and non-modified carbon dots with high quantum yield and crystallinity by one-pot hydrothermal method using a single carbon source and used for ClO− detection. Dyes Pigm 164:7–1310.1016/j.dyepig.2019.01.004 ↗
73. Kang C, Huang Y, Yang H, Yan XF, Chen ZP (2020) A review of carbon dots produced from biomass wastes. Nanomaterials (Basel) 10(11):231610.3390/nano10112316 ↗
74. Xue M, Zou M, Zhao J, Zhan Z, Zhao S (2015) Green preparation of fluorescent carbon dots from lychee seeds and their application for the selective detection of methylene blue and imaging in living cells. J Mater Chem B 3(33):6783–678910.1039/C5TB01073J ↗
75. Zhu L, Yin Y, Wang C-F, Chen S (2013) Plant leaf-derived fluorescent carbon dots for sensing, patterning and coding. J Mater Chem C 1(32):4925–493210.1039/c3tc30701h ↗
76. Praneerad J, Neungnoraj K, In I, Paoprasert P (2019) Environmentally friendly supercapacitor based on carbon dots from durian peel as an electrode. Key Eng Mater 803:115–11910.4028/www.scientific.net/KEM.803.115 ↗
77. Aji MP, Susanto, Wiguna PA, Sulhadi (2017) Facile synthesis of luminescent carbon dots from mangosteen peel by pyrolysis method. J Theor Appl Phys 11(2):119–12610.1007/s40094-017-0250-3 ↗
78. Jing HH, Bardakci F, Akgol S, Kusat K, Adnan M, Alam MJ, Gupta R, Sahreen S, Chen Y, Gopinath SCB, Sasidharan S (2023) Green carbon dots: synthesis, characterization, properties and biomedical applications. J Funct Biomater 14(1):2710.3390/jfb14010027 ↗
79. Wang C, Yang M, Shi H, Yao Z, Liu E, Hu X, Guo P, Xue W, Fan J (2022) Carbon quantum dots prepared by pyrolysis: investigation of the luminescence mechanism and application as fluorescent probes. Dyes Pigm 204:11043110.1016/j.dyepig.2022.110431 ↗
80. Chen Y, Lian H, Wei Y, He X, Chen Y, Wang B, Zeng Q, Lin J (2018) Concentration-induced multi-colored emissions in carbon dots: origination from triple fluorescent centers. Nanoscale 10(14):6734–674310.1039/C8NR00204E ↗
81. Ethordevic L, Arcudi F, Prato M (2019) Preparation, functionalization and characterization of engineered carbon nanodots. Nat Protoc 14(10):2931–295310.1038/s41596-019-0207-x ↗
82. Wang N, Wang Y, Guo T, Yang T, Chen M, Wang J (2016) Green preparation of carbon dots with papaya as carbon source for effective fluorescent sensing of Iron (III) and Escherichia coli. Biosens Bioelectron 85:68–7510.1016/j.bios.2016.04.089 ↗
83. Qiu Y, Gao D, Yin H, Zhang K, Zeng J, Wang L, Xia L, Zhou K, Xia Z, Fu Q (2020) Facile, green and energy-efficient preparation of fluorescent carbon dots from processed traditional Chinese medicine and their applications for on-site semi-quantitative visual detection of Cr(VI). Sens Actuators B: Chem 324:12872210.1016/j.snb.2020.128722 ↗
84. Shi Y, Liu J, Zhang Y, Bao J, Cheng J, Yi C (2021) Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe3+ detection and bioimaging. Chin Chem Lett 32(10):3189–319410.1016/j.cclet.2021.03.022 ↗
85. Choi Y, Jo S, Chae A, Kim YK, Park JE, Lim D, Park SY, In I (2017) Simple microwave-assisted synthesis of amphiphilic carbon quantum dots from A(3)/B(2) polyamidation monomer set. ACS Appl Mater Interfaces 9(33):27883–2789310.1021/acsami.7b06066 ↗
86. Shen Z, Zhang C, Yu X, Li J, Wang Z, Zhang Z, Liu B (2018) Microwave-assisted synthesis of cyclen functional carbon dots to construct a ratiometric fluorescent probe for tetracycline detection. J Mater Chem C 6(36):9636–964110.1039/C8TC02982B ↗
87. Wareing TC, Gentile P, Phan AN (2021) Biomass-based carbon dots: current development and future perspectives. ACS Nano 15(10):15471–1550110.1021/acsnano.1c03886 ↗
88. Architha N, Ragupathi M, Shobana C, Selvankumar T, Kumar P, Lee YS, Kalai Selvan R (2021) Microwave-assisted green synthesis of fluorescent carbon quantum dots from Mexican Mint extract for Fe(3+) detection and bio-imaging applications. Environ Res 199:11126310.1016/j.envres.2021.111263 ↗
89. Isnaeni, Rahmawati I, Intan R, Zakaria M (2018) Photoluminescence study of carbon dots from ginger and galangal herbs using microwave technique. J Phys: Conf Ser 985:012004
90. Tejwan N, Sharma A, Thakur S, Das J (2021) Green synthesis of a novel carbon dots from red Korean ginseng and its application for Fe2+ sensing and preparation of nanocatalyst. Inorg Chem Commun 134:10898510.1016/j.inoche.2021.108985 ↗
91. de Medeiros TV, Manioudakis J, Noun F, Macairan J-R, Victoria F, Naccache R (2019) Microwave-assisted synthesis of carbon dots and their applications. J Mater Chem C 7(24):7175–719510.1039/C9TC01640F ↗
92. Singh RK, Kumar R, Singh DP, Savu R, Moshkalev SA (2019) Progress in microwave-assisted synthesis of quantum dots (graphene/carbon/semiconducting) for bioapplications: a review. Mater Today Chem 12:282–31410.1016/j.mtchem.2019.03.001 ↗
93. Sun Y, Zhang M, Bhandari B, Yang C (2020) Recent development of carbon quantum dots: biological toxicity, antibacterial properties and application in foods. Food Rev Int 38(7):1513–153210.1080/87559129.2020.1818255 ↗
94. Li H, Huang J, Song Y, Zhang M, Wang H, Lu F, Huang H, Liu Y, Dai X, Gu Z, Yang Z, Zhou R, Kang Z (2018) Degradable carbon dots with broad-spectrum antibacterial activity. ACS Appl Mater Interfaces 10(32):26936–2694610.1021/acsami.8b08832 ↗
95. Lin R, Cheng S, Tan M (2022) Green synthesis of fluorescent carbon dots with antibacterial activity and their application in Atlantic mackerel (Scomber scombrus) storage. Food Funct 13(4):2098–210810.1039/D1FO03426J ↗
96. Lu F, Zhang Y, Cheng J, Zhang M, Luo J, Qu H, Zhao Y, Wang Q (2019) Maltase and sucrase inhibitory activities and hypoglycemic effects of carbon dots derived from charred Fructus crataegi. Mater Res Express 6(12):12500510.1088/2053-1591/ab4fd8 ↗
97. Sun Z, Lu F, Cheng J, Zhang M, Zhu Y, Zhang Y, Kong H, Qu H, Zhao Y (2018) Hypoglycemic bioactivity of novel eco-friendly carbon dots derived from traditional Chinese medicine. J Biomed Nanotechnol 14(12):2146–215510.1166/jbn.2018.2653 ↗
98. Liu X, Wang Y et al (2018) Novel Phellodendri Cortex (Huang Bo)-derived carbon dots and their hemostatic effect. Nanomedicine (Lond) 13(4):391–40510.2217/nnm-2017-0297 ↗
99. Yan X, Zhao Y, Luo J, Xiong W, Liu X, Cheng J, Wang Y, Zhang M, Qu H (2017) Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots. J Nanobiotechnol 15(1):6010.1186/s12951-017-0296-z ↗
100. Cheng J, Zhang M, Sun Z et al (2019) Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived carbon dots. Nanomedicine 14:43110.2217/nnm-2018-0285 ↗