journal article·2023-03

Mechanical and antibacterial properties of resin co-filled with mesoporous silica and graphene quantum dots

Shuxin Lu, Hongyu Zhang, Maozhou Chai, Xiaohong Yao, Xiangyu Zhang, Yongqiang Yang

Carbon Letters· Volume 33· Issue 2
Publisher page

Abstract

Poor mechanical properties and bacterial infection are the main problems faced by dental restorative resins in clinical use. In this study, graphene quantum dots (GQDs) grafted with imidazole groups and mesoporous silica (MSN) are co-filled in a dental resin to impart excellent antimicrobial activity and mechanical properties to the dental resin. The higher specific surface area of GQDs and MSN results in an increased contact area with the resin matrix, which enhances the strength of the dental composite resin. The introduction of GQDs significantly improves the antimicrobial activity of the resin. The inhibition efficiency of the composite resin against Streptococcus mutans reached 99.9% with the addition of GQDs at only 0.2 wt.%. When MSN and GQDs are co-filled, MSN interferes with the release of GQDs, thus reducing the antimicrobial activity of the dental resin but improving the cyto-compatibility. By reasonably adjusting the amount of GQDs and MSN, the dental composite resin can exhibit excellent antimicrobial properties, mechanical properties and cyto-compatibility at the same time.
Source: expertdata · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Graphene and Nanomaterials Applications · Oral microbiology and periodontitis research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (45)

Show source-provided references
1. Gou Y, Meghil MM, Pucci CR, Breschi L, Pashley DH, Cutler CW, Niu L, Li J, Tay FR (2018) Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities. Acta Biomater 75:171–18210.1016/j.actbio.2018.06.008 ↗
2. Selwitz RH, Ismail AI, Pitts NB (2007) Dental caries. Lancet 369:5l–5910.1016/S0140-6736(07)60031-2 ↗
3. Pashaa M, Muhammadb N, Nayyera M, Bokharia JH, Ashrafa H, Safi SZ, Kaleema M (2020) Synthesis of an anti-cariogenic experimental dental composite containing novel drug-decorated copper particles. Mater Sci Eng C 114:111040
4. Walters NJ, Xia W, Salih V, Ashley PF, Young AM (2016) Poly(propylene glycol) and urethane dimethacrylates improve conversion of dental composites and reveal complexity of cytocompatibility testing. Dent Mater 32:264–27710.1016/j.dental.2015.11.017 ↗
5. Imazato S (2012) Antibacterial resin monomers based on quaternary ammonium and their benefits in restorative dentistry. Jpn Dent Sci Rev 48:115–12510.1016/j.jdsr.2012.02.003 ↗
6. Peres MA, Macpherson LMD, Weyant PJ, Daly B, Venturelli R, Mathur MR, Listl S, Celeste RK, Guarnizo-Herreño CC, Kearns C, Benzian H, Allison P, Watt RG (2019) Oral diseases: a global public health challenge. Lancet 394:249–26010.1016/S0140-6736(19)31146-8 ↗
7. Boaro LCC, Campos LM, Varca GHC, Dos Santos TMR, Marques PA, Sugii MM, Saldanha NR, Cogo-Müllerc K, Brandt WC, Bragad RR, Parrab DF (2019) Antibacterial resin-based composite containing chlorhexidine for dental applications. Dent Mater 35:909–91810.1016/j.dental.2019.03.004 ↗
8. Cheng L, Zhang K, Zhou C, Weir MD, Zhou X, Xu H (2016) One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms. Int J Oral Sci 8:172–18110.1038/ijos.2016.13 ↗
9. Zhao I, Mei M, Burrow MF, Lo EC, Chu C (2017) Prevention of secondary caries using silver diamine fluoride treatment and casein phosphopeptide-amorphous calcium phosphate modified glass-ionomer cement. J Dent 57:38–4410.1016/j.jdent.2016.12.001 ↗
10. Ferracane JL (2021) Resin composite-state of the art. Dent Mater 27:29–3810.1016/j.dental.2010.10.020 ↗
11. Dias HB, Bernardi MIB, Bauab TM, Hernandes AC, Rastelli ANDS (2019) Titanium dioxide and modified titanium dioxide by silver nanoparticles as an anti biofilm filler content for composite resins. Dent Mater 35:e36–e4610.1016/j.dental.2018.11.002 ↗
12. Pallana S, Araujo MVF, Cilli R, Prakki A (2012) Mechanical properties and characteristics of developmental copolymers incorporating catechin or chlorhexidine. Dent Mater 28:687–69410.1016/j.dental.2012.03.003 ↗
13. Zhang J, Wu R, Fan Y, Liao S, Wang Y, Wen Z, Xu X (2014) Antibacterial dental composites with chlorhexidine and mesoporous silica. J Dent Res 93:1283–128910.1177/0022034514555143 ↗
14. Jin J, Liu W, Zhang W, Chen Q, Yuan Y, Yang L, Wang Q (2014) Nano-ZnO/ZnO–HAPw prepared via sol–gel method and antibacterial activities of inorganic agents on six bacteria associated with oral infections. J Nanopart Res 16:265810.1007/s11051-014-2658-x ↗
15. Kang X, Qiao Y, Lu X, Jiang S, Li W, Wang X, Xu X, Qi J, Xiao Y, Du Y (2019) Tocopherol polyethylene glycol succinate-modified hollow silver nanoparticles for combating bacteria-resistance. Biomater Sci 7:2520–253210.1039/C9BM00343F ↗
16. Pan N, Liu Y, Fan X, Jiang Z, Ren X, Liang J (2017) Preparation and characterization of antibacterial graphene oxide functionalized with Npolymeric N-halamine. J Mater Sci 52:1996–200610.1007/s10853-016-0488-1 ↗
17. Pan N, Liu Y, Ren X, Huang T (2018) Fabrication of cotton fabrics through in-situ reduction of polymeric N-halamine modified graphene oxide with enhanced ultraviolet-blocking, self-cleaning, and highly efficient, and monitorable antibacterial properties. Colloid Surface A 555:765–77110.1016/j.colsurfa.2018.07.056 ↗
18. Ramachandran R, Rani M, Senthan S, Jeong YT, Kabilan S (2011) Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives. Eur J Med Chem 46:1926–193410.1016/j.ejmech.2011.02.036 ↗
19. Hu Y, Shen Y, Wu X, Tu X, Wang G (2018) Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. Eur J Med Chem 143:958–96910.1016/j.ejmech.2017.11.100 ↗
20. Wang P, Wang M, Zeng D, Xiang M, Rao J, Liu Q, Liu L, Wu Z, Li Z, Song B, Yang S (2019) Rational optimization and action mechanism of novel imidazole (or Imidazolium)-labeled 1,3,4-oxadiazole thioethers as promising antibacterial agents against plant bacterial diseases. J Agric Food Chem 67:3535–354510.1021/acs.jafc.8b06242 ↗
21. Geng C, Fan L, Niu H, Liu L, Zhao F, Zhang J, Dong H, Yu S (2021) Improved anti-organic fouling and antibacterial properties of PVDF ultrafiltration membrane by one-step grafting imidazole-functionalized graphene oxide. Mater Sci Eng C 131:11251710.1016/j.msec.2021.112517 ↗
22. Samuel SP, Li S, Mukherjee I, Guo Y, Patel AC, Baran G, Wei Y (2009) Mechanical properties of experimental dental composites containing a combination of mesoporous and nonporous spherical silica as fillers. Dent Mater 25:296–30110.1016/j.dental.2008.07.012 ↗
23. Wang R, Habib E, Zhu X (2017) Synthesis of wrinkled mesoporous silica and its reinforcing effect for dental resin composites. Dent Mater 33:1139–114810.1016/j.dental.2017.07.012 ↗
24. Li Z, Barnes JC, Bosoy A, Stoddart JF, Zink JI (2012) Mesoporous silica nanoparticles in biomedical applications. Chem Soc Rev 41:2590–260510.1039/c1cs15246g ↗
25. Chen W, Li R, Li Z, Yang Y, Zhu H, Liu J (2019) Promising copper oxide-histidine functionalized graphene quantum dots hybrid for electrochemical detection of hydroquinone. J Alloy Compd 777:1001–100910.1016/j.jallcom.2018.10.252 ↗
26. Li N, Li R, Li Z, Yang Y, Wang G, Gu Z (2019) Pentaethylenehexamine and histidine-functionalized graphene quantum dots for ultrasensitive fluorescence detection of microRNA with target and molecular beacon double cycle amplification strategy. Sensor Actuat B-Chem 283:666–67610.1016/j.snb.2018.12.082 ↗
27. He K, Li R, Li Z, Yang Y (2020) Controllable synthesis of superparamagnetic NiCo-graphene quantum dot-graphene composite with excellent dispersion for high performance magnetic field-controlled electrochemical flow hybrid supercapacitor. Electrochim Acta 353:13652410.1016/j.electacta.2020.136524 ↗
28. Thorat SB, Diaspro A, Salerno M (2014) In vitro investigation of coupling-agent-free dental restorative composite based on nano-porous alumina fillers. J Dent 42:279–28610.1016/j.jdent.2013.12.001 ↗
29. Shen D, Yang J, Li X, Zhou L, Zhang R, Li W, Chen L, Wang R, Zhang F, Zhao DY (2014) Biphase stratification approach to three-dimensional dendritic biodegradable mesoporous silica nanospheres. Nano Lett 14:923–93210.1021/nl404316v ↗
30. Zandinejad AA, Atai M, Pahlevan A (2006) The effect of ceramic and porous fillers on the mechanical properties of experimental dental composites. Dent Mater 22:382–38710.1016/j.dental.2005.04.027 ↗
31. Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS (1992) Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature 359:710–712210.1038/359710a0 ↗
32. Beck JS, Vartuli JC, Roth WJ, Leonowicz ME, Kresge CT, Schmitt KD, Chu CTW, Olson DH, Sheppard EW, McCullen SB, Higgins JB, Schlenker JL (1992) A new family of mesoporous molecular sieves prepared with liquid crystal templates. J Am Chem Soc 114:10834–1084310.1021/ja00053a020 ↗
33. Grün M, Lauer I, Unger KK (1997) The synthesis of micrometer-and submicrometer-size spheres of ordered mesoporous oxide MCM-41. Adv Mater 9:254–25710.1002/adma.19970090317 ↗
34. Wilson KS, Zhang K, Antonucci JM (2005) Systematic variation of interfacial phase reactivity in dental nanocomposites. Biomaterials 26:5095–510310.1016/j.biomaterials.2005.01.008 ↗
35. Dhar S, Majumder T, Mondal SP (2016) Graphene quantum dot-sensitized ZnO nanorod/polymer schottky junction UV detector with superior external quantum efficiency, detectivity, and responsivity. ACS Appl Mater Inter 8:31822–3183110.1021/acsami.6b09766 ↗
36. Wang L, Li W, Wu B, Li Z, Wang S, Liu Y, Pan D, Wu M (2016) Facile synthesis of fluorescent graphene quantum dots from coffee grounds for bioimaging and sensing. Chem Eng J 300:75–8210.1016/j.cej.2016.04.123 ↗
37. Wang X, Li R, Fan S, Li Z, Wang G, Gu Z, Liu J (2017) D-penicillamine-functionalized graphene quantum dots for fluorescent detection of Fe3+ in iron supplement oral liquids. Sensor Actuat B-Chem 243:211–22010.1016/j.snb.2016.08.013 ↗
38. Ge J, Lan M, Zhou B, Liu W, Guo L, Wang H, Jia Q, Niu G, Huang X, Zhou H, Meng X, Wang P, Lee CS, Zhang W, Han X (2014) A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation. Nat Commun 5:459610.1038/ncomms5596 ↗
39. Liu F, Jang M, Ha H, Kim JH, Cho YH, Seo TS (2013) Facile synthetic method for pristine graphene quantum dots and graphene oxide quantum dots: origin of blue and green luminescence. Adv Mater 25:3657–366210.1002/adma.201300233 ↗
40. Wang X, Cao L, Yang S, Lu F, Meziani MJ, Tian L, Sun K, Bloodgood MA, Sun YP (2010) Bandgap-like strong fluorescence in functionalized carbon nanoparticles. Angew Chem 122:5438–544210.1002/ange.201000982 ↗
41. Anilkumar P, Wang X, Cao L, Sahu S, Liu J, Wang P, Korch K, Tackett KN II, Parenzan A, Sun Y (2011) Toward quantitatively fluorescent carbon-based “quantum” dots. Nanoscale 3:2023–202710.1039/c0nr00962h ↗
42. Liu F, Sun B, Jiang X, Aldeyab SS, Zhang Q, Zhu M (2014) Mechanical properties of dental resin/composite containing urchin-like hydroxyapatite. Dent Mater 30:1358–136810.1016/j.dental.2014.10.003 ↗
43. Sideridou ID, Karabela MM (2009) Effect of the amount of 3-methacyloxypropyltrimethoxysilane coupling agent on physical properties of dental resin nanocomposites. Dent Mater 25:1315–132410.1016/j.dental.2009.03.016 ↗
44. Curtis AR, Palin WM, Fleming GJP, Shortall ACC, Marquis PM (2009) The mechanical properties of nanofilled resin-based composites: The impact of dry and wet cyclic pre-loading on bi-axial flexure strength. Dent Mater 25:188–19710.1016/j.dental.2008.06.003 ↗
45. Wang J, Wei Y, Shi X, Gao H (2013) Cellular entry of graphene nanosheets: the role of thickness, oxidation and surface adsorption. RSC Adv 36:15776–1578210.1039/c3ra40392k ↗