Carbon-based artificial metabzymes: Atomic-level design and precision metabolic reprogramming for disease intervention
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Carbon-based nanomaterials in photodynamic therapy of cancer10.1016/j.carbon.2025.119986 ↗
2. Recent developments in the use of carbon-based nanomaterials in cancer therapy10.1016/j.jconrel.2025.114100 ↗
3. Cu-doping site regulation in carbon dots for concurrent cuproptosis-like death anti-bacteria and osteogenesis of infected bone defects10.1186/s12951-025-03871-4 ↗
4. Carbon-based nanozymes in cancer therapy: current trends and future prospects
5. Nanozymes: innovative therapeutics in the battle against neurodegenerative diseases10.3390/ijms26083522 ↗
6. Artificial metabzyme-driven metabolic reprogramming and precision oncology10.1002/ctm2.70215 ↗
7. Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review10.1038/s41419-025-07583-3 ↗
8. Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders10.3389/fnmol.2025.1681079 ↗
9. An artificial metabzyme for tumour-cell-specific metabolic therapy10.1038/s41565-024-01733-y ↗
10. N, P, S codoped carbon nanozymes with enhanced peroxidase-like activity and binding affinity for total antioxidant capacity assay10.1021/acsanm.3c04650 ↗
11. Unveiling the glucose oxidase-like and catalase-like activities of highly conjugated 3,4,9,10-perylenetetracarboxylic dianhydride for boosting biofuel cells10.1002/adfm.202400617 ↗
12. Lactate-modulating nanozyme-mediated mitochondrial respiration block for tumor immunosuppression remodeling10.1002/anie.202422203 ↗
13. Oxidation of hydrogen sulfide to polysulfide and thiosulfate by a carbon nanozyme: therapeutic implications with an emphasis on Down syndrome
14. Biodegradable hollow MnO2 decorated by carbon dots with cholesterol depletion capability for cascaded amplification of sono-immunotherapy10.1016/j.biomaterials.2025.123559 ↗
15. An unusual application of multifunctional nanozyme derived from COF: augmenting chemoimmunotherapy while attenuating cardiotoxicity10.1002/adfm.202412862 ↗
16. In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy10.1038/s41467-018-03903-8 ↗
17. Advances in artificial metabzymes for macrophage polarization in tumor metabolic immunotherapy
18. Engineering carbons by elemental doping and processing procedures for design of functional materials10.1002/smll.202503508 ↗
19. The promises and reality of metal-CO2 batteries10.1038/s44359-025-00099-1 ↗
20. Bifunctional cascading nanozymes based on carbon dots promotes photodynamic therapy by regulating hypoxia and glycolysis10.1021/acsnano.3c03169 ↗
21. Nitrogen-centered lactate oxidase nanozyme for tumor lactate modulation and microenvironment remodeling10.1021/jacs.3c02005 ↗
22. MXene/carbon dots nanozyme composites for glutathione detection and tumor therapy10.3390/nano14131090 ↗
23. Mercaptosuccinic acid-based carbon quantum dots as peroxidase-like nanozymes inducing cell pyroptosis for tumor-specific therapy10.1021/acsanm.4c01125 ↗
24. Graphitic C6N6-supported dual Cu/Zn single-atom nanozyme mimicking allosteric regulation for intelligent switching biosensing
25. Biomimetic smart mesoporous carbon nanozyme as a dual-GSH depletion agent and O2 generator for enhanced photodynamic therapy10.1016/j.actbio.2022.06.001 ↗
26. A NADH oxidase nanozyme restores redox homeostasis to ameliorate multi-organ aging and ischemic cardiomyopathy10.34133/research.0973 ↗
27. Revolutionize the chemistry of carbon dots by sulfur doping: a review10.1080/17415993.2025.2579608 ↗
28. Regulating the atomic active center by covalent organic framework-derived photothermal nanozyme to arm self-gelling powder for bacterial wound healing10.1021/acsnano.4c13899 ↗
29. Integrating Pt nanoparticles with carbon nanodots to achieve robust cascade superoxide dismutase-catalase nanozyme for antioxidant therapy10.1016/j.nantod.2023.101768 ↗
30. Glucose oxidase, an enzyme “ferrari”: its structure, function, production and properties in the light of various industrial and biotechnological applications10.3390/biom12030472 ↗
31. Nanozyme sensor array plus solvent-mediated signal amplification strategy for ultrasensitive ratiometric fluorescence detection of exosomal proteins and cancer identification10.1021/acs.analchem.1c02010 ↗
32. Controllable synthesis of boron-doped Zn-N-C single-atom nanozymes for the ultrasensitive colorimetric detection of p-phenylenediamine10.1016/j.bios.2022.114294 ↗
33. Carbon-based nanozymes: catalytic mechanisms, performance tuning, and environmental and biomedical applications10.1039/D5AY00997A ↗
34. Reconfigurable self-assembling photocatalytic magnetic liquid metal microrobot swarm for microplastic capture and degradation10.1002/smll.202501351 ↗
35. Versatile dual-emissive boron-nitrogen Co-doped carbon dots: unlocking efficient electroluminescent light-emitting diodes with breakthrough EQE approaching 7%10.1016/j.cej.2025.163146 ↗
36. More than one enzyme: exploring alternative FMN-dependent L-lactate oxidases for biosensor development10.1021/acsomega.4c01897 ↗
37. Reactive sulfur species and protein persulfidation: an emerging redox axis in human health and disease10.3390/cimb47090765 ↗
38. Sulfide regulation and catabolism in health and disease10.1038/s41392-025-02231-w ↗
39. Biomimetic structural design in 3D-printed scaffolds for bone tissue engineering
40. β-Cyclodextrin-based nanoassemblies for the treatment of atherosclerosis10.1093/rb/rbae071 ↗
41. Redox regulation: mechanisms, biology and therapeutic targets in diseases10.1038/s41392-024-02095-6 ↗
42. Oxidized carbon nanoparticles enhance cellular energetics with application to injured brain10.1002/adhm.202401629 ↗
43. N, P, or S-doped carbon nanotubes as dual mimics of NADH oxidase and cytochrome c reductase10.1007/s12274-023-5393-8 ↗
44. Pleozymes: pleiotropic oxidized carbon nanozymes enhance cellular metabolic flexibility10.3390/nano14242017 ↗
45. Metal-free carbon nanozyme as nicotinamide adenine dinucleotide oxidase mimic over a broad pH range for coenzyme regeneration10.1021/acs.chemmater.2c03138 ↗
46. The developing trend about heteroatom/metal-doped CDs as nanozyme mimics for the detection and imaging of active biomolecules10.1016/j.ccr.2025.217530 ↗
47. Metal-doped carbon nitride: an all-in-one photocatalyst10.1039/D3EY00123G ↗
48. Carbon nanosphere based bifunctional oxidoreductase nano-catalytic agent to mitigate hypoxia in cancer cells10.1016/j.ijbiomac.2023.123466 ↗
49. Boosting the catalase-like activity of SAzymes via facile tuning of the distances between neighboring atoms in single-iron sites
50. Insight into iron leaching from an ascorbate-oxidase-like Fe-N-C nanozyme and oxygen reduction selectivity10.1002/anie.202302463 ↗
51. Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy10.1186/s12943-024-02205-6 ↗
52. Energy metabolism in health and diseases10.1038/s41392-025-02141-x ↗
53. Nanotechnology for tumor ferroptosis
54. Research progress on immunotherapy targeting the tumor immune microenvironment for cholangiocarcinoma, oncol. Transl
55. The warburg effect redefined: a kinetic and regulatory perspective
56. Metabolic reprogramming in the post-metastatic tumor microenvironment: multi-omics insights into determinants of immunotherapy response
57. Crosstalk between colorectal tumor metabolism and immune cells in the tumor microenvironment10.1097/ot9.0000000000000083 ↗
58. Bmetallic nanozyme amplifier for synergistic ferroptosis-cuproptosis and metabolic reprogramming to reshape immunosuppressive tumor microenvironment10.1002/advs.202512764 ↗
59. Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy10.1016/j.apsb.2024.12.014 ↗
60. Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics10.1186/s13045-023-01498-2 ↗
61. A mechanical immune checkpoint inhibitor stiffens tumor cells to potentiate antitumor immunity
62. A metal-free mesoporous carbon dots/silica hybrid type I photosensitizer with enzyme-activity for synergistic treatment of hypoxic tumor10.1002/adfm.202300818 ↗
63. A versatile nanozyme-based NADH circulating oxidation reactor for tumor therapy through triple cellular metabolism disruption10.1002/smll.202311027 ↗
64. Axially chlorinated carbon nanodots for hypoxia-tolerant neutrophil-mimicking photoenzymatic cascade therapy against postoperative tumor recurrence10.1021/acsnano.5c07997 ↗
65. Removing barriers to tumor ‘oxygenation’: depleting glutathione nanozymes in cancer therapy10.2147/IJN.S515734 ↗
66. Amyloid-β in alzheimer's disease: structure, toxicity, distribution, treatment, and prospects
67. Inhibiting immune crosstalk by modulation of the intracellular function and extracellular environment of diseased microglia to boost Parkinson's disease therapy10.1021/acsnano.5c01068 ↗
68. Tau-targeting nanoparticles for treatment of alzheimer's disease
69. Chiral carbon nanodots modulate α-synuclein homeostasis to combat parkinson's disease10.1002/smtd.202500557 ↗
70. A novel biomimetic nanovesicle containing caffeic acid-coupled carbon quantum dots for the the treatment of Alzheimer's disease via nasal administration10.1186/s12951-024-02912-8 ↗
71. Enhanced blood-brain barrier penetrability of BACE1 siRNA-loaded prussian blue nanocomplexes for alzheimer's disease synergy therapy
72. Sirtuins at the crossroads between mitochondrial quality control and neurodegenerative diseases: structure, regulation, modifications, and modulators10.14336/AD.2022.1123 ↗
73. Proteostasis and neuroinflammation in alzheimer's disease
74. Doped graphene to mimic the bacterial NADH oxidase for one-step NAD+ supplementation in mammals10.1021/jacs.2c12336 ↗
75. Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells10.1038/s41467-024-47947-5 ↗
76. On electrostatic interactions of adenosine triphosphate-insulin-degrading enzyme revealed by quantum mechanics/molecular mechanics and molecular dynamics10.1002/qub2.61 ↗
77. Metabolic and immune crosstalk in cardiovascular disease10.1161/CIRCRESAHA.125.325496 ↗
78. Manganese-loaded carbon nanoparticles ameliorate ANCA-Associated vasculitis by inhibiting ferroptosis10.1186/s12951-025-03725-z ↗
79. Bioinspired cascade-catalytic scaffold to prevent adverse remodeling of heart valve under pathological conditions via conversion of ·O2- into NO10.1021/acsnano.5c12816 ↗
80. Prussian blue nanozyme featuring enhanced superoxide dismutase-like activity for myocardial ischemia reperfusion injury treatment10.1021/acsnano.4c14445 ↗
81. Nanozymes for non-neoplastic diseases: catalytic therapy redefined10.1002/agt2.70150 ↗
82. Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities10.1038/s42255-024-01015-w ↗
83. Metabolic reprogramming in skin wound healing10.1093/burnst/tkad047 ↗
84. Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review10.1038/s41419-025-07583-3 ↗
85. Carbon dots with integrated photothermal antibacterial and heat-enhanced antioxidant properties for diabetic wound healing10.1002/smll.202403160 ↗
86. Thermoresponsive antioxidant metal-free carbon nanodot hydrogel: an effective therapeutic approach for ocular surface disease10.1126/sciadv.adt8775 ↗
87. Glucose oxidase: an emerging multidimensional treatment option for diabetic wound healing
88. Glucose-activated programmed hydrogel with self-switchable enzyme-like activity for infected diabetic wound self-adaptive treatment10.1002/adma.202419158 ↗
89. Glucose-responsive cascade nanozyme for controlled ROS release and bacterial carbon metabolic reprogramming in infected diabetic wounds10.1016/j.jconrel.2025.114590 ↗
90. Glucose-activated nanoreactor initiating cascade reaction to remodel immune microenvironment for promoting diabetic wound healing10.1021/acsami.5c23502 ↗
91. Advancements in nanozymes research for the management of chronic wounds
92. Nanozymes for accelerating the foot wound healing: a review10.2147/IJN.S517671 ↗
93. Oxidative stress in health and disease: mechanisms and therapeutic perspectives10.3390/ijms27062681 ↗
94. Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review10.1186/s11658-023-00489-y ↗
95. Nanozyme hydrogels remodel pathological microenvironment for temporomandibular joint osteoarthritis therapy via inhibiting MAPK signal pathway
96. Implications of nanotechnology for the treatment of dry eye disease: recent advances10.1016/j.ijpharm.2025.125355 ↗
97. Injectable metal-free carbon dot-integrated hydrogel for regulating inflammation via macrophage metabolic reprograming in spinal cord injury therapy10.1021/acsnano.5c13627 ↗
98. Redox homeostasis strategy for inflammatory macrophage reprogramming in rheumatoid arthritis based on ceria oxide nanozyme-complexed biopolymeric micelles10.1021/acsnano.2c09127 ↗
99. Ruthenium-based metal-organic framework with reactive oxygen and nitrogen species scavenging activities for alleviating inflammation diseases10.1016/j.nantod.2022.101627 ↗
100. Discovery of lipoxygenase-like materials for inducing ferroptosis10.1021/acsnano.4c04741 ↗