Sonodynamic and Enzyme-like Activities of Niobium-based Coatings: Antimicrobial, Cell Proliferation and Cell Differentiation

Currently, to repair infectious bone defects is still a clinical serious challenge.Here, we prepared a heterojunction coating of niobium oxide on pure niobium surface by using microarc oxidation and hydrothermal treatment.We found that the obtained heterogeneous junctions exhibited synchronously enzyme-like and ultrasonic dynamic properties triggered by ultrasound treatment, especially in acidic microenvironment of mimic bacterial infection.Uinder these key conditions, oxidase-like activity of the heterogeneous junctions was enhanced, generating several reactive oxygen species which can kill bacteria and remove their biofilm.Their clearance rates were 91.43% and 98.57%, respectively.Under simulated physiological conditions, ultrasound enhanced antioxidant-like enzyme activity of this kind heterogeneous junction, thereby scavenging reactive oxygen species, alleviating oxidative stress, and promoting proliferation and osteo-differentiation of rBMSCs.In conclousion, the obtained niobium-based coatings with sonodynamic and enzyme-like activities has profound potential application prospects in infectious bone repair.