Synthesis and characterization of biodegradable AZ31/calcium phosphate glass composites for orthopedic applications
Source abstract
Abstract
The advent of biodegradable implants is one of the greatest achievements in the healthcare industry; however, practical drawbacks have hindered their initial stunning progress. Fabrication of ceramic-metal composites partially improves the performance of these medical devices. In this research, AZ31-calcium phosphate glass composites with different glass contents (0–15 wt.%) were synthesized via the powder metallurgy route. The results demonstrated that increasing the glass particle content improved microhardness and compressive strength up to 40% and 50%, respectively. Moreover, corrosion resistance to the SBF solution was reduced and the cell viability of AZ31-calcium phosphate glass composites was increased considerably by the addition of glass particles, based on MTT assay. Eventually, higher biocompatibility and appropriate cell attachment in the composite containing 15 wt.% glass indicated that AZ31-calcium phosphate glass composite has a great potential for using as orthopedic biodegradable implants.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Magnesium Alloys: Properties and Applications · Aluminum Alloys Composites Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Staiger MP, Pietak AM, Huadmai J, Dias G (2006) Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials 27(9):1728–173410.1016/j.biomaterials.2005.10.003 ↗
2. Li N, Zheng Y (2013) Novel magnesium alloys developed for biomedical application: a review. J Mater Sci Technol 29(6):489–50210.1016/j.jmst.2013.02.005 ↗
3. Agarwal S, Curtin J, Duffy B, Jaiswal S (2016) Biodegradable magnesium alloys for orthopaedic applications: a review on corrosion, biocompatibility and surface modifications. Mater Sci Eng C 68:948–96310.1016/j.msec.2016.06.020 ↗
4. Gu X-N, Zheng Y-F (2010) A review on magnesium alloys as biodegradable materials. Front Mater Sci China 4(2):111–11510.1007/s11706-010-0024-1 ↗
5. Virtanen S (2011) Biodegradable Mg and Mg alloys: corrosion and biocompatibility. Mater Sci Eng B 176(20):1600–160810.1016/j.mseb.2011.05.028 ↗
6. Xin Y, Hu T, Chu PK (2011) In vitro studies of biomedical magnesium alloys in a simulated physiological environment: a review. Acta Biomater 7(4):1452–145910.1016/j.actbio.2010.12.004 ↗
7. Castellani C, Lindtner RA, Hausbrandt P, Tschegg E, Stanzl-Tschegg SE, Zanoni G, Beck S, Weinberg A-M (2011) Bone-implant interface strength and osseointegration: biodegradable magnesium alloy versus standard titanium control. Acta Biomater 7(1):432–44010.1016/j.actbio.2010.08.020 ↗
8. Yun Y, Dong Z, Yang D, Schulz MJ, Shanov VN, Yarmolenko S, Xu Z, Kumta P, Sfeir C (2009) Biodegradable Mg corrosion and osteoblast cell culture studies. Mater Sci Eng C 29(6):1814–182110.1016/j.msec.2009.02.008 ↗
9. Song Y, Shan D, Chen R, Zhang F, Han E-H (2009) Biodegradable behaviors of AZ31 magnesium alloy in simulated body fluid. Mater Sci Eng C 29(3):1039–104510.1016/j.msec.2008.08.026 ↗
10. Gu X, Zheng Y, Cheng Y, Zhong S, Xi T (2009) In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials 30(4):484–49810.1016/j.biomaterials.2008.10.021 ↗
11. Kirkland NT, Lespagnol J, Birbilis N, Staiger MP (2010) A survey of bio-corrosion rates of magnesium alloys. Corros Sci 52(2):287–29110.1016/j.corsci.2009.09.033 ↗
12. Witte F, Hort N, Vogt C, Cohen S, Kainer KU, Willumeit R, Feyerabend F (2008) Degradable biomaterials based on magnesium corrosion. Curr Opinion Solid State Mater Sci 12(5–6):63–7210.1016/j.cossms.2009.04.001 ↗
13. Zhang E, Yin D, Xu L, Yang L, Yang K (2009) Microstructure, mechanical and corrosion properties and biocompatibility of Mg–Zn–Mn alloys for biomedical application. Mater Sci Eng C 29(3):987–99310.1016/j.msec.2008.08.024 ↗
14. Witte F, Kaese V, Haferkamp H, Switzer E, Meyer-Lindenberg A, Wirth CJ, Windhagen H (2005) In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials 26(17):3557–356310.1016/j.biomaterials.2004.09.049 ↗
15. Li Y, Hodgson PD, Wen C (2010) The effects of calcium and yttrium additions on the microstructure, mechanical properties and biocompatibility of biodegradable magnesium alloys. J Mater Sci 46(2):365–37110.1007/s10853-010-4843-3 ↗
16. Gray-Munro JE, Strong M (2009) The mechanism of deposition of calcium phosphate coatings from solution onto magnesium alloy AZ31. J Biomed Mater Res A 90(2):339–35010.1002/jbm.a.32107 ↗
17. Hornberger H, Virtanen S, Boccaccini AR (2012) Biomedical coatings on magnesium alloys - a review. Acta Biomater 8(7):2442–245510.1016/j.actbio.2012.04.012 ↗
18. Aboudzadeh N, Dehghanian Ch, Shokrgozar MA, “Synthesis, microstructure and mechanical properties of Mg - 5Zn - 0.3Ca/nHa nanocomposites”, URL: http://ijmse.iust.ac.ir/article-1-992-en.html
19. Abdal-hay A, Dewidar M, Lim J, Lim JK (2014) Enhanced biocorrosion resistance of surface modified magnesium alloys using inorganic/organic composite layer for biomedical applications. Ceram Int 40(1):2237–224710.1016/j.ceramint.2013.07.142 ↗
20. Rojaee R, Fathi M, Raeissi K, Taherian M (2014) Electrophoretic deposition of bioactive glass nanopowders on magnesium based alloy for biomedical applications. Ceram Int 40(6):7879–788810.1016/j.ceramint.2013.12.135 ↗
21. Wen C, Guan S, Peng L, Ren C, Wang X, Hu Z (2009) Characterization and degradation behavior of AZ31 alloy surface modified by bone-like hydroxyapatite for implant applications. Appl Surf Sci 255(13–14):6433–643810.1016/j.apsusc.2008.09.078 ↗
22. Batmanghelich F, Ghorbani M (2013) Effect of pH and carbon nanotube content on the corrosion behavior of electrophoretically deposited chitosan–hydroxyapatite–carbon nanotube composite coatings. Ceram Int 39(5):5393–540210.1016/j.ceramint.2012.12.046 ↗
23. Trojanová Z, Száraz Z (2011) “Magnesium alloys based composites", In Magnesium alloys design, processing and properties, IntechOpen, pp.501–526
24. Brown A, Zaky S, Ray H, Sfeir C (2014) “Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction.,” Acta Biomater, no. September10.1016/j.actbio.2014.09.008 ↗
25. Witte F, Feyerabend F, Maier P, Fischer J, Störmer M, Blawert C, Dietzel W, Hort N (2007) Biodegradable magnesium-hydroxyapatite metal matrix composites. Biomaterials 28(13):2163–217410.1016/j.biomaterials.2006.12.027 ↗
26. Ratna Sunil B, Ganapathy C, Sampath Kumar TS, Chakkingal U (2014) Processing and mechanical behavior of lamellar structured degradable magnesium-hydroxyapatite implants. J Mech Behav Biomed Mater 40C:178–18910.1016/j.jmbbm.2014.08.016 ↗
27. Jurczyk MU, Jurczyk K, Miklaszewski A, Jurczyk M (2011) Nanostructured titanium-45S5 Bioglass scaffold composites for medical applications. Mater Des 32(10):4882–488910.1016/j.matdes.2011.06.005 ↗
28. Ratna Sunil B, Sampath Kumar TS, Chakkingal U, Nandakumar V, Doble M (2014) Nano-hydroxyapatite reinforced AZ31 magnesium alloy by friction stir processing: a solid state processing for biodegradable metal matrix composites. J Mater Sci Mater Med 25(4):975–98810.1007/s10856-013-5127-7 ↗
29. Rahaman MN (2014) Bioactive ceramics and glasses for tissue engineering, In book: Tissue engineering using ceramics and polymers, pp.67–11410.1533/9780857097163.1.67 ↗
30. Salih V, Franks K, James M, Hastings GW, Knowles JC, Olsen I (2000) Development of soluble glasses for biomedical use part II: the biological response of human osteoblast cell lines to phosphate-based soluble glasses. J Mater Sci Mater Med 11(10):615–62010.1023/A:1008901612674 ↗
31. Kasuga T (2005) Bioactive calcium pyrophosphate glasses and glass-ceramics. Acta Biomater 1:55–6410.1016/j.actbio.2004.08.001 ↗
32. Bitar M, Salih V, Mudera V, Knowles JC, Lewis MP (2004) “Soluble phosphate glasses: in vitro studies using human cells of hard and soft tissue origin,” vol. 25, pp. 2283–229210.1016/j.biomaterials.2003.08.054 ↗
33. Sanzana ES, Navarro M, Macule F, Suso S, Planell JA, Ginebra MP (2008) Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes. Acta Biomater 4(6):1924–193310.1016/j.actbio.2008.04.023 ↗
34. Uo M, Mizuno M, Kuboki Y, Makishima A, Watari F (1998) Properties and cytotoxicity of water soluble Na O - CaO - P2O5 glasses. Biomaterials 19(24):2277–228410.1016/S0142-9612(98)00136-7 ↗
35. Khorasanizadeh F, Eftekhari Yekta B and Safaei-Naeini Y "Crystallization and sinterability behavior of bioresorbable CaO-P2O5 -Na2O-TiO2 glass ceramics for bone regeneration application", URL: http://ijmse.iust.ac.ir/article-1-520-en.html
36. Kiani A, Cahill LS, Ali E, Neel A, Hanna JV, Smith ME, Knowles JC (2010) Physical properties and MAS-NMR studies of titanium phosphate-based glasses. Mater Chem Phys 120(1):68–7410.1016/j.matchemphys.2009.10.023 ↗
37. ElBatal HA, Khalil EMA, Hamdy YM (2009) In vitro behavior of bioactive phosphate glass–ceramics from the system P2O5–Na2O–CaO containing titania. Ceram Int 35(3):1195–120410.1016/j.ceramint.2008.06.004 ↗
38. “ASTM E9 - 09 Standard test methods of compression testing of metallic materials at room temperature.” [Online]. Available: http://www.astm.org/Standards/E9.htm. Accessed 07 Oct 2014
39. “ASTM G31–72(2004) Standard practice for laboratory immersion corrosion testing of metals.” [Online]. Available: http://www.astm.org/DATABASE.CART/HISTORICAL/G31-72R04.htm. Accessed 07 Oct 2014
40. Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27(15):2907–291510.1016/j.biomaterials.2006.01.017 ↗
41. “ISO 10993-5:2009 - Biological evaluation of medical devices -- Part 5: Tests for in vitro cytotoxicity.” [Online]. Available: http://www.iso.org/iso/catalogue_detail.htm?csnumber=36406. Accessed 07 Oct 2014
42. Kannan MB, Raman RKS (2008) “Evaluating the stress corrosion cracking susceptibility of Mg–Al–Zn alloy in modified-simulated body fluid for orthopaedic implant application”, Scripta Materialia, Elsevier
43. Chawla BN, Shen Y (2001) Mechanical behavior of particle reinforced metal matrix composites. Adv Eng Mater 3(6):357–37010.1002/1527-2648(200106)3:6<357::AID-ADEM357>3.0.CO;2-I ↗
44. Dunand D, Mortensen A (1991) Thermal mismatch dislocations produced by large particles in a strain-hardening matrix. Mater Sci Eng A 135:179–184
45. Liu C, Wan P, Tan LL, Wang K, Yang K (2014) Preclinical investigation of an innovative magnesium-based bone graft substitute for potential orthopaedic applications. J Orthop Translat 2(3):139–14810.1016/j.jot.2014.06.002 ↗
46. Xu N, Ye X, Wei D, Zhong J, Chen Y, Xu G, He D (2014) 3D artificial bones for bone repair prepared by computed tomography-guided fused deposition modeling for bone repair. ACS Appl Mater Interfaces 6(17):14952–1496310.1021/am502716t ↗
47. Zhang S, Zhang X, Zhao C, Li J, Song Y, Xie C, Tao H, Zhang Y, He Y, Jiang Y, Bian Y (2010) Research on an Mg-Zn alloy as a degradable biomaterial. Acta Biomater 6(2):626–64010.1016/j.actbio.2009.06.028 ↗
48. Yingchao S, Niu L, Lu Y, Lian J, Lia G (2013) Preparation and corrosion behavior of calcium phosphate and hydroxyapatite conversion coatings on AM60 magnesium alloy. J Electrochem Soc 160(11):C536–C54110.1149/2.036311jes ↗
49. Chakkalakal DA, Mashoof AA, Novak J, Strates BS, McGuire MH (1994) Mineralization and pH relationships in healing skeletal defects grafted with demineralized bone matrix. J Miomed Mater Res 28(12):1439–144310.1002/jbm.820281209 ↗
50. Zhu H, Guo ZK, Jiang XX, Li H, Wang XY, Yao HY, Zhang Y, MaO N (2009) A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc 5(3):550–56010.1038/nprot.2009.238 ↗