To develop biodegradable Mg-based metal ceramic composites as bone implant material
Source abstract
Abstract
Biodegradable materials for orthopaedic implants have gained much attention due to their similar properties to natural bone. Magnesium-based alloys are considered the best biodegradable material for bone substitute materials. However, magnesium alloys have very high corrosion rate. Research has been focused to fabricate and to make their composites to control their corrosion rates in human physiological environment and to develop the ability of forming bone-like apatite layer on their surface. In the present study, Mg–Zn–Mn metal alloys were selected for making their composites with hydroxyapatite (HAp) and bio-glasses. HAp was prepared by the co-precipitation method and bio-glasses (45S5P7) were prepared by the melting and quenching method. Samples from metal–ceramic composites were prepared by the powder metallurgy route in various compositions. Furthermore, samples were characterized for their phases, microstructure, corrosion behaviour, mechanical properties and bioactivity. The composites showed bioactivity in simulated body fluid (SBF) solution and their young’s modulus values were obtained near to the human bone. The degradation properties, as studied in SBF solution, revealed Mg-based alloy composites having approximately 10% bio-active glasses and 10% β-tri-calcium phosphate resulted in the reduction of the corrosion rate.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Bone Tissue Engineering Materials · Hydrogen Storage and Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (21)
Show source-provided references
1. Witte F 2010 Acta Biomater. 6 168010.1016/j.actbio.2010.02.028 ↗
2. Kraus T, Fischerauer S F, Hänzi A C, Uggowitzer P J, Löffler J F and Weinberg A M 2012 Acta Biomater. 8 123010.1016/j.actbio.2011.11.008 ↗
3. Witte F, Hort N, Vogt C, Cohen S, Kainer K U and Willumeit R 2008 Curr. Opin. Solid State Mater. Sci. 12 6310.1016/j.cossms.2009.04.001 ↗
4. Kirkland N T, Birbilis N and Staiger M P 2012 Acta Biomater. 8 92510.1016/j.actbio.2011.11.014 ↗
5. Witte F, Kaese V, Haferkamp H, Meyer S E, Lindenberg A and Wirth C J 2005 Biomaterials 26 355710.1016/j.biomaterials.2004.09.049 ↗
6. Janning C 2010 Acta Biomater. 6 186110.1016/j.actbio.2009.12.037 ↗
7. Castellani C 2011 Acta Biomater. 7 43210.1016/j.actbio.2010.08.020 ↗
8. Witte F, Fischer J, Nellesen J, Vogt C, Vogt J and Donath T 2010 Acta Biomater. 6 179210.1016/j.actbio.2009.10.012 ↗
9. Zberg B, Uggowitzer P J and Löffler J F 2009 Nat. Mater. 8 88710.1038/nmat2542 ↗
10. Yang J, Cui F and Lee I S 2011 Ann. Biomed. Eng. 39 185710.1007/s10439-011-0300-y ↗
11. Zheng Y F, Gu X N, Xi Y L and Chai D L 2010 Acta Biomater. 6 178310.1016/j.actbio.2009.10.009 ↗
12. Anderson J M, Rodriguez A and Chang D T 2008 Semin. Immunol. 20 8610.1016/j.smim.2007.11.004 ↗
13. Xu L, Pan F, Yu G, Yang L, Zhang E and Yang K 2009 Biomaterials 30 512
14. Thomann M, Krause C, Angrisani N, Bormann D, Hassel T and Windhagen H 2010 J. Biomed. Mater. Res. 93 160910.1002/jbm.a.32639 ↗
15. Yang J, Cui F, Lee I S, Zhang Y, Yin Q and Xia H 2012 J. Biomater. Appl. 27 15310.1177/0885328211398161 ↗
16. Kokubo T, Matsushita T and Takadama H 2007 J. Eur. Ceram. Soc. 27 155310.1016/j.jeurceramsoc.2006.04.015 ↗
17. Singh V K and Reddy B R 2012 Ceram. Int. 38 533310.1016/j.ceramint.2012.03.039 ↗
18. Jones J R 2012 Acta Biomater. 9 445710.1016/j.actbio.2012.08.023 ↗
19. Huang W, Day D E, Kittiratanapiboon K and Rahaman M N 2006 J. Mater. Sci.: Mater. Med. 17 583
20. Majhi M R, Pyare R and Singh S P 2015 Int. J. Sci. Eng. Res. 2 1
21. Rai P, Rai A, Kumar V, Chaturvedi R K and Singh V K 2019 Ceram. Int. 45 1689310.1016/j.ceramint.2019.05.234 ↗