Size-controlled synthesis of biodegradable nanocarriers for targeted and controlled cancer drug delivery using salting out cation
Source abstract
Abstract
Research for synthesis of size-controlled carriers is currently challenging one. In this research paper, a method for size-controlled synthesis of biodegradable nanocarriers is proposed and described. Salting out method is suitable for both hydrophilic and hydrophobic drugs for the encapsulation on carriers. This synthetic method is based on polylactic acid (PLA) and non-ionic carboxymethyl cellulose (CMC) composed by CaCl2 as salting out agent. This method permits size-controlled synthesis of particles between 50 and 400 nm simply by varying the concentration of salting out agents. We have prepared cisplatin (CDDP)-loaded PLA-CMC nanocarriers by salting out method, with varying salting out agent (CaCl2) concentrations as 0.05, 0.2, 0.35 and 0.5 M. The nanocarriers were characterized for their size, surface charge and morphology by atomic force microscope, zeta potential analyser and transmission electron microscope, respectively. The encapsulation efficiency and in-vitro drug-releasing behaviour of the nanocarriers were investigated. The cytotoxicity effect of nanocarriers and drug-loaded nanocarriers was tested against MCF-7 breast cancer cell line.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications · Advanced Drug Delivery Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. Bhowmik D, Chiranjib, Margret Chandira R, Tripathi K K and Sampath Kumar K P 2010 Int. J. PharmTech. Res. 2 2143
2. Gupta A S 2011 Nanomed. Nanotechnol. Biol. Med. 7 76310.1016/j.nano.2011.04.001 ↗
3. Shapira A, Livney Y D, Broxterman J H and Assaraf Y G 2011 Drug Resist. Updat. 14 15010.1016/j.drup.2011.01.003 ↗
4. Kranti P M, Praful B D, Prashant B M, Naseer Maliyakkal M, Ranjith Kumar A, Sreenivasa Reddy M and Udupa N 2014 Bull. Mater. Sci. 37 94510.1007/s12034-014-0030-5 ↗
5. Thambi T, Deepagan V G, Yoon H Y, Han H S, Kim S H, Son S, Jo D G, Ahn C H, Suh Y D, Kim K, Kwon I C, Lee D S and Park J H 2014 Biomaterials 35 173510.1016/j.biomaterials.2013.11.022 ↗
6. Panyam J and Labhasetwar V 2003 Adv. Drug Deliv. Rev. 55 32910.1016/S0169-409X(02)00228-4 ↗
7. Yoo J W, Doshi N and Mitragotri S 2011 Adv. Drug Deliv. Rev. 63 124710.1016/j.addr.2011.05.004 ↗
8. Lepeltier E, Bourgaux C and Couvreur P 2014 Adv. Drug Deliv. Rev. 71 8610.1016/j.addr.2013.12.009 ↗
9. Iversena T G, Skotlanda T and Sandvig K 2011 Nano Today 6 17610.1016/j.nantod.2011.02.003 ↗
10. Astete C E and Sabliov C M 2006 J. Biomater. Sci. Polym. Ed. 17 24710.1163/156856206775997322 ↗
11. Ranjith K A, Gopal V S, Aravind K G, Praful B D, Karthik A, Naseer M, Sreenivasa R M and Udupa N 2012 Bull. Mater. Sci. 35 31910.1007/s12034-012-0313-7 ↗
12. Pal S L, Jana P, Manna P K, Mohanta G P and Manavalan R 2011 J. App. Pharm. Sci. 6 228
13. Soppimath K S, Aminabhavi T M, Kulkarni A R and Rudzinski W E 2001 J. Control Release 70 110.1016/S0168-3659(00)00339-4 ↗
14. Hans M L and Lowman A M 2002 Curr. Opin. Solid State Mater. Sci. 6 31910.1016/S1359-0286(02)00117-1 ↗
15. Barichello J M, Morishita M, Takayama K and Nagai T 1999 Drug Dev. Ind. Pharm. 25 47110.1081/DDC-100102197 ↗
16. Quintanar-Guerrero D, Allemann E, Fessi H and Doelker E 1998 Drug Dev. Ind. Pharm. 24 111310.3109/03639049809108571 ↗
17. Bankar S K, Chaudhari A V, Mahale N B and Chaudhari S R 2014 J. Adv. Drug Deliv. 1 82
18. Ibrahim H, Bindschaedler C, Doelker E, Buri P and Gurny R 1992 Int. J. Pharm. 87 23910.1016/0378-5173(92)90248-Z ↗
19. LeHoux J G and Dupuis G 2007 Carbohydr. Polym. 68 29510.1016/j.carbpol.2006.12.008 ↗
20. Fischer B, Heffeter P, Kryeziu K, Gille L, Meier S M, Berger W, Kowol C R and Keppler B K 2014 Dalton Trans. 43 109610.1039/C3DT52388H ↗
21. El-Hag Ali A, Abd El-Rehim A, Kamal H, Hegazy D and El-Sayed A 2008 J. Macromol. Sci. Pure Appl. Chem. 45 62810.1080/10601320802168751 ↗
22. Galindo-Rodriguez S, Allemann E, Fessi H and Doelker E 2004 Pharm. Res. 21 142810.1023/B:PHAM.0000036917.75634.be ↗
23. Tabatabaei Rezaei S J, Nabid M R, Niknejad H and Entezami A A 2012 Polymer 53 348510.1016/j.polymer.2012.05.056 ↗
24. Nagavarma B V N, Hemant K S Yadav, Ayaz A, Vasudha L S and Shivakumar H G 2012 Asian J. Pharm. Clin. Res. 5 16
25. Basavaraja C, Kim J K and Huh D S 2013 Mater. Sci. Eng. B 178 16710.1016/j.mseb.2012.11.001 ↗
26. Biswal D R and Singh R P 2004 Carbohydr. Polym. 57 37910.1016/j.carbpol.2004.04.020 ↗
27. Habibi N 2014 Spectrochim. Acta Part A 131 5510.1016/j.saa.2014.04.039 ↗
28. Bajpai A K and Sweta L 2013 Bull. Mater. Sci. 36 1510.1007/s12034-013-0432-9 ↗
29. Wokadala O C, Emmambux N M and Ray S S 2014 Carbohydr. Polym. 112 21610.1016/j.carbpol.2014.05.095 ↗
30. Wang Y, Zhou J, Qiu L, Wang X, Chen L, Liu T and Di W 2014 Biomaterials 35 429710.1016/j.biomaterials.2014.01.035 ↗
31. Lei D, Liu J, Ye F, Chen F and Zhao G 2014 Food Hydrocolloids 41 25010.1016/j.foodhyd.2014.04.006 ↗
32. Rajan M, Raj V, Al-Arfaj A A and Murugan A M 2013 Int. J. Pharm. 453 51410.1016/j.ijpharm.2013.06.030 ↗
33. Muzzarell R A A, Tanfani F, Mariotti S and Emanuelli M 1982 Carbohydr. Polym. 2 14510.1016/0144-8617(82)90060-1 ↗
34. Kumari K and Kundu P P 2008 Bull. Mater. Sci. 31 15910.1007/s12034-008-0028-y ↗
35. Du J Z, Mao C Q, Yuan Y Y, Yang X Z and Wang J 2014 Biotechnol. Adv. 32 78910.1016/j.biotechadv.2013.08.002 ↗