Fabrication and characterization of porous hydroxyapatite ocular implant followed by anin vivo study in dogs
Source abstract
Abstract
Porous hydroxyapatite ocular implant was fabricated by a novel and simple method using hydroxyapatite powder synthesized in the laboratory. The porosity and pore size of the implant were controlled to make it light in weight as well as suitable for rapid vascularization after implantation. The implant was characterized by X-ray diffraction studies, infrared spectra and chemical analysis for phase purity and chemical composition. The pore morphology and pore size distribution of the samples were investigated by scanning electron microscope (SEM). Thereafter, efficacy of the implant was examined byin vivo study in dogs. Clinical, haematological and radiological studies indicated the suitability of the implant for replacement of the lost eye of human patients.
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Research context
OpenAlex topics: Ocular Disorders and Treatments · Facial Trauma and Fracture Management · Bone Tissue Engineering Materials
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References (26)
Show source-provided references
1. Aoki H 1991 inScience and medical applications of hydroxy- apatite (Japan: JAAS Press)
2. Aoki Het al 1987Medical Progress through Technology 12 21310.1007/978-94-009-3361-3_18 ↗
3. Christmas N Jet al 1998Arch. Ophthalmol. 116 119910.1001/archopht.116.9.1199 ↗
4. Dorozhkin S V and Epple M 2002Angew. Chem. Int. Ed. 41 313010.1002/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1 ↗
5. Dutton J J 1991Ophthalmology 98 37010.1016/S0161-6420(91)32304-2 ↗
6. Ferrone P J and Dutton J J 1992Ophthalmology 99 37610.1016/S0161-6420(92)31975-X ↗
7. Gougelmann H P 1976Int. Ophthalmol. Clin. 10 689
8. Grote J J 1987Am. J. Otol. 8 396
9. Ichikawa T, Hirota K and Kanitani H 1996J. Oral. Implantol. 22 232
10. Kingery W D, Bowen H K and Uhlmann D R 1976 inIntroduc- tion to ceramics (New York: Wiley) p. 526
11. Lavernia C and Schoenung J M 1991Am. Ceram. Bull. 70 95
12. Legeross R Z 1988Adv. Dent. Res. 2 16410.1177/08959374880020011101 ↗
13. Mules P H 1885Trans. Ophthalmol. Soc. UK 5 200
14. Munoz E R, Diaz J R, Rodriguez J R, Brostow W and Castano V M 2001J. Mats. Sc.: Mats. Med. 12 305
15. Ozawa S and Kasugai S 1996Biomaterials 17 2310.1016/0142-9612(96)80751-4 ↗
16. Passi V, Marin T W, Miotti A and Pareti A 1991 inCeramics in substitutive and reconstructive surgery (ed.) P Vincenzini (San Diego, USA: Elsevier Science Publication) p. 467
17. Perry A C 1990Adv. Ophthalmic Plast. Reconstr. Surg. 8 75
18. Perry A C 1991Ophthalmol. Clin. North Am. 4 173
19. Rosen H M 1991Plast. Reconstr. Surg. 88 107610.1097/00006534-199112000-00020 ↗
20. Ruedemann A D 1946Am. J. Ophthalmol. 29 94710.1016/0002-9394(46)90925-7 ↗
21. Shields C L, Shields J A, Eagle R C and de Potter P 1991Am. J. Ophthalmol. 111 36310.1016/S0002-9394(14)72323-2 ↗
22. Shields C Let al 1993Trans. Am. Ophthalmol. Soc. 91 177
23. Shin Yet al 1992J. Mats. Sc.: Mats. Med. 3 219
24. Sinha M K, Basu D and Sen P S 2000Interceram 2 102
25. Tampieri A, Celotti G, Sprio S, Delcogliano A and Franzese S 2001Biomaterials 22 136510.1016/S0142-9612(00)00290-8 ↗
26. Uchida A, Araki N, Shinto Y, Yorshkawa H, Kurisaki E and Ono K 1990J. Bone Joint Surg. (Br.) B72 29810.1302/0301-620X.72B2.2155908 ↗