Morphology and Surface Properties of Poly (L-lactic acid)/Captopril Composite Nanofiber Membranes
Source abstract
Abstract
In this study, Poly (L-lactic acid)/Captopril composite nanofiber membranes were electrospun for drug delivery. Different mass fractions of Poly (L-lactic acid), different ratios of Captopril and the influences of PEG4000 added in the spinning solution are discussed. The morphology, chemical components, the surface areas and pore sizes, wettability of the composite nanofiber membranes were investigated. The results showed that the diameters of the composite nanofibers increased with the increase of Poly (L-lactic acid) mass fractions, the diameters decreased with the increase of Captopril content as well as the addition of the surfactant. Fourier Transform Infrared (FT-IR) showed the chemical components of Captopril remained unchanged when it was electrospun into the composite nanofibers. The surface areas pore width and pore volume of the composite nanofibers became a little larger than those of poly (L-lactic acid) nanofibers, and the wettability of the composite nanofiber membranes was better than those of poly (L-lactic acid) nanofiber membranes. Wettability was improved by an increase of the drug load amount.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials · Tissue Engineering and Regenerative Medicine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Jiangnan University, Wuxi, Jiangsu CHINA
Wannan Medical College, Wuhu, Anhui Province CHINA
Anhui Polytechnic University, Wuhu, Anhui Province CHINA
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