journal article·2025-04-01Open access

Bioreactors as Additive Manufacturing Environments

Orkan Telhan

Abstract

This article discusses the evolving use of bioreactors, beyond traditional life sciences and bioengineering, in fields such as architecture, fashion, and product design. It explores the role of bioreactors in additive fabrication, highlighting their distinct characteristics compared with conventional digital manufacturing. The discussion is centered on the differences in materializing biologically-active (living) versus biologically-passive, or biologically-derived (nonliving) matter in which ingredients require closed-loop fabrication environments that differ from traditional additive manufacturing tools. Two novel biofabrication platforms, Microbial Design Studio and B | reactor are presented as examples with case studies demonstrating their use in various manufacturing workflows with live cells. The article emphasizes the unique capabilities of bioreactors in engaging with living matter and facilitating complex interactions between biological, algorithmic, and mechanical systems in additive manufacturing.
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Research context

OpenAlex topics: Additive Manufacturing and 3D Printing Technologies · 3D Printing in Biomedical Research · Innovative Microfluidic and Catalytic Techniques Innovation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Stuart Weitzman School of Design, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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