Superparamagnetic nanoparticles’ potential in hyperthermia therapy and targeted drug delivery systems

Abstract Cancer is among the fatal diseases that affect individuals worldwide. According to World Health Organization statistics, if the current trends continue, the world will see a significant increase in cancer cases over the next two decades, leading to a staggering number of deaths by 2040. Therefore, finding innovative strategies for cancer treatment has become a critical priority. Recently, magnetic nanoparticles (MNPs) have been widely applied in cancer diagnosis via magnetic resonance imaging, in hyperthermia, and in drug delivery to specific organs due to their unique physicochemical properties. However, the most significant challenge of using MNPs is ensuring compliance with in vivo nano-safety regulations. MNP characteristics necessary for biomedical applications, followed by a description of their physical, chemical, and magnetic properties. The preparation of MNPs and the development of a superior method suitable for magnetic drug delivery and hyperthermia applications are surveyed. Furthermore, their physicochemical properties and their effects on biocompatibility, biodistribution, and pharmacokinetic behavior, are reported. The functionalization and surface modification of MNPs, which are intensively exploited in cancer treatment, particularly for drug delivery and hyperthermia, are demonstrated. Some studies of the incorporation of MNPs in the diagnosis, treatment, and imaging of cancer are summarized. Furthermore, the effects of combining antineoplastic drugs via drug delivery systems with hyperthermia treatment to achieve an efficient synergetic effect are extensively reviewed. Finally, this review article provides an overview of recent innovations, future challenges, prospects, and developments that advance MNP therapeutic applications, particularly in oncology.