(K,Na)NbO3-based lead-free ceramic/polyvinylidene fluoride piezoelectric composite for biomimetic wound healing via endogenous electric field simulation
Source abstract
Abstract
Electrical stimulation that mimics endogenous electric fields represents a promising therapeutic strategy for wound healing. In this study, a lead-free piezoelectric composite film was fabricated by incorporating (K,Na)NbO 3 (KNN) ceramics into a polyvinylidene fluoride (PVDF) matrix via tape casting. The introduction of KNN fillers significantly enhanced the β-phase content and piezoelectric output of PVDF. Under ultrasound irradiation, the resulting KNN/PVDF film effectively promoted fibroblast proliferation and migration in vitro, achieving a 54.84% migration rate within 24 h and upregulating key wound-repair genes, including TGF-β and VEGF. In vivo, the composite film markedly accelerated the healing of full-thickness skin defects in rats, promoted neovascularization, and achieved approximately 95% wound closure by day 9. These results demonstrate that the KNN/PVDF composite film provides an effective wireless platform for biomimetic electrical stimulation in tissue regeneration.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Wound Healing and Treatments · Planarian Biology and Electrostimulation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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