LYC loaded ferritin nanoparticles for intracerebral delivery and the attenuation of neurodegeneration in D-gal-induced mice
Source abstract
Abstract
Recombinant human H-ferritin nanocage (rHuHF) loaded with natural antioxidative lycopene molecules (LYC) was successfully constructed for the first time, aiming to enrich LYC in the brain and explore the regulation mechanism of this nanoparticles on neurodegeneration. Here, the mouse model was constructed via D-galactose-induced neurodegeneration based on behavioural analysis, histological observation, immunostaining analysis, Fourier transform infrared microscopy, and Western blotting analysis for the regulation of rHuHF-LYC. rHuHF-LYC improved the behaviour of mice in a dose-dependent manner. Besides, rHuHF-LYC can attenuate neuronal damage, maintain the number of Nissl body, increase the level of unsaturated fat, inhibit the activation of glial cells, and prevent excessive accumulation of neurotoxic proteins in the hippocampus of mice. More importantly, synaptic plasticity was activated in response to the regulation of rHuHF-LYC with excellent biocompatibility and biosafety. This study proved the validity of the direct use of natural antioxidant nano drugs for treating neurodegeneration, providing a promising therapeutic option against further imbalances in the degenerative brain microenvironment.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Biochemical effects in animals · MicroRNA in disease regulation · Alzheimer's disease research and treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (28)
Show source-provided references
1. Biomimetic dendrimer-peptide conjugates for early multi-target therapy of Alzheimer's disease by inflammatory microenvironment modulation10.1002/adma.202100746 ↗
2. Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia10.1002/anie.201802309 ↗
3. Regulation of cell uptake and cytotoxicity by nanoparticle core under the controlled shape,size, and surface chemistries10.1021/acsnano.9b04407 ↗
4. Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases10.1038/s41467-020-16544-7 ↗
5. Advance of sporadic Alzheimer's disease animal models10.1002/med.21624 ↗
6. Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway10.1016/j.neuint.2011.10.005 ↗
7. Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons10.1016/j.brainres.2013.10.005 ↗
8. A review for the pharmacological effect of lycopene in central nervous system disorders10.1016/j.biopha.2018.12.151 ↗
9. Stability of lycopene during heating and illumination in a model system10.1016/S0308-8146(02)00146-2 ↗
10. Lycopene in human health10.1016/j.lwt.2020.109323 ↗
11. Endo/lysosome-escapable delivery depot for improving BBB transcytosis and neuron targeted therapy of Alzheimer's disease10.1002/adfm.201909999 ↗
12. ROS-targeted depression therapy via BSA-incubated ceria nanoclusters10.1021/acs.nanolett.2c01334 ↗
13. Ferritin nanocarrier traverses the blood brain barrier and kills glioma10.1021/acsnano.7b06969 ↗
14. Fenozyme protects the integrity of the blood-brain barrier against experimental cerebral malaria10.1021/acs.nanolett.9b03774 ↗
15. Target delivering paclitaxel by ferritin heavy chain nanocages for glioma treatment10.1016/j.jconrel.2019.12.010 ↗
16. Encapsulation of beta-carotene within ferritin nanocages greatly increases its water-solubility and thermal stability10.1016/j.foodchem.2013.10.115 ↗
17. PM1-loaded recombinant human H-ferritin nanocages: a novel pH-responsive sensing platform for the identification of cancer cells10.1016/j.ijbiomac.2021.12.068 ↗
18. Encapsulation of curcumin in recombinant human H-chain ferritin increases its water-solubility and stability10.1016/j.foodres.2014.05.054 ↗
19. Formation of nanocomplexes comprising whey proteins and fucoxanthin: characterization, spectroscopic analysis, and molecular docking10.1016/j.foodhyd.2016.09.027 ↗
20. Ferritin cage for encapsulation and delivery of bioactive nutrients: from structure, property to applications10.1080/10408398.2016.1149690 ↗
21. His-mediated reversible self-assembly of ferritin nanocages through two different switches for encapsulation of cargo molecules10.1021/acsnano.0c06670 ↗
22. Synthesis of homogeneous protein-stabilized rutin nanodispersions by reversible assembly of soybean (Glycine max) seed ferritin10.1039/C5RA03542B ↗
23. The size flexibility of ferritin nanocage opens a new way to prepare nanomaterials10.1002/smll.201701045 ↗
24. Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions10.1016/j.ijbiomac.2018.12.230 ↗
25. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase10.1016/j.biopsych.2010.04.010 ↗
26. Biochemical changes indicate developmental stage in the hippocampal formation10.1021/acschemneuro.8b00471 ↗
27. How neuroinflammation contributes to neurodegeneration10.1126/science.aag2590 ↗
28. Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer's disease10.1038/s41593-018-0080-x ↗