Three-dimensional printing bilayer membranous nanofiber scaffold for inhibiting scar hyperplasia of skin
Source abstract
Abstract
Hypertrophic scar (HS) is the manifestation of pathological wound healing, which affects the beauty of patients, and even affects the normal physical functions of patients. We aimed to develop a 3D printing layer membranous nanofiber scaffold similar to skin structure. Among them, poly (lactic-co-glycolic acid) copolymer (PLGA) nanofibers were used as the "epidermis" layer above, and a decellular dermis matrix (dECM) nanofiber scaffold was used as the "dermis" layer below. In vitro, experimental results showed that PLGA and dECM nanofiber scaffolds had good biocompatibility. In vivo experiments showed that BLM nanofiber scaffolds could inhibit collagen fiber deposition and angiogenesis, to inhibit the formation of hypertrophic scars. This study shows a simple and effective method for preventing and inhibiting the formation of hypertrophic scars.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Dermatologic Treatments and Research · Wound Healing and Treatments · Skin Protection and Aging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (23)
Show source-provided references
1. Molecular changes underlying hypertrophic scarring following burns involve specific deregulations at all wound healing stages (inflammation, proliferation and maturation)10.3390/ijms22020897 ↗
2. Gazing long into a clinical and social abyss?Treating hypertrophic scarring and keloids10.1089/rej.2021.0037 ↗
3. PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application10.1080/10717544.2021.1938756 ↗
4. 2015 · 53 · 659
5. 2012 · 33(29) · 7028
6. Sawkins · 2013 · 9(8) · 7865
7. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid
8. Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo110.1038/s41419-021-03481-6 ↗
9. Inhibition of hypertrophic scar formation with oral asiaticoside treatment in a rabbit ear scar model10.1111/iwj.13561 ↗
10. Usnic acid inhibits hypertrophic scarring in a rabbit ear model by suppressing scar tissue angiogenesis10.1016/j.biopha.2018.06.176 ↗
11. ABT-263 reduces hypertrophic scars by targeting apoptosis of myofibroblasts
12. Scarless human fetal skin repair is intrinsic to the fetal fibroblast and occurs in the absence of an inflammatory response10.1046/j.1524-475X.1994.20411.x ↗
13. Hypertrophic scars, keloids, and contractures.The cellular and molecular basis for therapy10.1016/S0039-6109(05)70576-4 ↗
14. CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation10.1073/pnas.1607710113 ↗
15. The roles of inflammation in keloid and hypertrophic scars10.3389/fimmu.2020.603187 ↗
16. Keratinocyte-fibroblast interactions in wound healing10.1038/sj.jid.5700786 ↗
17. Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids10.3390/ijms19030711 ↗
18. Three dimensional printing bilayer membrane scaffold promotes wound healing10.3389/fbioe.2019.00348 ↗
19. Effect of artesunate combined with fractional CO2 laser on the hypertrophic scar in a rabbit model
20. Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture10.1007/BF00371799 ↗
21. Collagen structure and stability10.1146/annurev.biochem.77.032207.120833 ↗
22. The Vancouver Scar Scale: an administration tool and its interrater reliability10.1097/00004630-199509000-00013 ↗
23. Current and upcoming therapies to modulate skin scarring and fibrosis10.1016/j.addr.2018.08.009 ↗