Self-healing, antibacterial and anti-inflammatory chitosan-PEG hydrogels for ulcerated skin wound healing and drug delivery
Source abstract
Abstract
Great efforts have been performed on the production of advanced biomaterials with the combination of self-healing and wound healing properties in implant/tissue engineering biomedical area. Inspired by this idea, chitosan (CHI) based hydrogels can be used to treat a less investigated class of harmful chronic wounds: ulcers or pressure ulcers. Thus, CHI was crosslinked with previously synthesized polyethylene glycol diacid (PEG-diacid) to obtain different CHI-PEG hydrogel formulations with high H-bonding tendency resulting in self-repair ability. Here presented results show biocompatible, antibacterial, anti-inflammatory, and self-healing CHI-PEG hydrogels with a promising future in the treatment of ulcerated wounds by a significant improvement in metabolic activity (94.51 ± 4.38 %), collagen and elastin quantities (2.12 ± 0.63 μg collagen and 4.97 ± 0.61 μg elastin per mg dermal tissue) and histological analysis. Furthermore, cefuroxime (CFX), tetracycline (TCN) and amoxicillin (AMX) antibiotics, and acetylsalicylic acid (ASA) anti-inflammatory agent were sustainedly released for enhancing antibacterial and anti-inflammatory activities of hydrogels.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Wound Healing and Treatments · Silk-based biomaterials and applications · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (63)
Show source-provided references
1. A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications10.1002/cben.201400025 ↗
2. Recent advances of emerging green chitosan-based biomaterials with potential biomedical applications: a review10.1016/j.carres.2021.108368 ↗
3. Antibacterial catechol-based hyaluronic acid, chitosan and poly (N-vinyl pyrrolidone) coatings onto Ti6Al4V surfaces for application as biomedical implant10.1016/j.ijbiomac.2021.05.034 ↗
4. Chitosan as an environment friendly biomaterial – a review on recent modifications and applications10.1016/j.ijbiomac.2019.10.113 ↗
5. Chitosan-based biomaterials for tissue engineering10.1016/j.eurpolymj.2012.12.009 ↗
6. Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: a review10.1016/j.carbpol.2020.115839 ↗
7. Recent advancements in applications of chitosan-based biomaterials for skin tissue engineering
8. Chitosan gel to treat pressure ulcers: a clinical pilot study10.3390/pharmaceutics10010015 ↗
9. Pressure ulcer prevalence and risk factors during prolonged surgical procedures10.1016/j.aorn.2011.03.014 ↗
10. Functional hydrogels as wound dressing to enhance wound healing10.1021/acsnano.1c04206 ↗
11. Controlled local drug delivery strategies from chitosan hydrogels for wound healing10.1080/17425247.2017.1247803 ↗
12. Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects10.1038/s41427-019-0124-z ↗
13. Gelation mechanism and structural dynamics of chitosan self-healing hydrogels by in situ SAXS and coherent X-ray scattering10.1021/acsmacrolett.9b00683 ↗
14. The design, mechanism and biomedical application of self-healing hydrogels10.1016/j.cclet.2017.05.007 ↗
15. A brief overview on preparation of self-healing polymers and coatings via hydrogen bonding interactions
16. Design considerations for hydrogel wound dressings: strategic and molecular advances10.1089/ten.teb.2019.0281 ↗
17. Self-healing gels based on constitutional dynamic chemistry and their potential applications10.1039/C4CS00219A ↗
18. Functional hydrogels as wound dressing to enhance wound healing10.1021/acsnano.1c04206 ↗
19. Research status of self-healing hydrogel for wound management: a review10.1016/j.ijbiomac.2020.08.109 ↗
20. A novel self-healing polydopamine-functionalized chitosan-arginine hydrogel with enhanced angiogenic and antibacterial activities for accelerating skin wound healing10.1016/j.cej.2021.130302 ↗
21. Ultrafast fabrication of self-healing and injectable carboxymethyl chitosan hydrogel dressing for wound healing10.1021/acsami.1c02089 ↗
22. Advances in multifunctional chitosan-based self-healing hydrogels for biomedical applications10.1039/D1TB01363G ↗
23. Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing
24. Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing10.1016/j.carbpol.2021.118770 ↗
25. A self-healing and injectable oxidized quaternized guar gum/carboxymethyl chitosan hydrogel with efficient hemostatic and antibacterial properties for wound dressing10.1016/j.colsurfb.2021.112207 ↗
26. Hydroxybutyl chitosan/ oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds
27. pH/Glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing10.1021/acsnano.1c11040 ↗
28. Synthesis and characterization of reinforced poly(ethylene glycol)/chitosan hydrogel as wound dressing materials10.1002/mame.201200054 ↗
29. 2009
30. 2017
31. PEG-chitosan hydrogel with tunable stiffness for study of drug response of breast cancer cells10.3390/polym8040112 ↗
32. Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents10.1016/j.polymer.2012.05.027 ↗
33. Applied rheology as tool for the assessment of chitosan hydrogels for regenerative medicine10.3390/polym13132189 ↗
34. Amine coupling through EDC/NHS: a practical approach
35. A double-network polysaccharide-based composite hydrogel for skin wound healing10.1016/j.carbpol.2021.117870 ↗
36. Modern wound dressings: hydrogel dressings10.3390/biomedicines9091235 ↗
37. Relationship between structure and rheology of hydrogels for various applications10.3390/gels7040255 ↗
38. Injectable hydrogels: from laboratory to industrialization10.3390/polym13040650 ↗
39. 2013
40. A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapy10.1016/j.ijpharm.2015.01.052 ↗
41. Competitive biological activities of chitosan and its derivatives: antimicrobial, antioxidant, anticancer, and anti-inflammatory activities10.1155/2018/1708172 ↗
42. Chitosan based scaffolds and their applications in wound healing
43. Biofilms in wounds: a review of present knowledge10.12968/jowc.2014.23.11.570 ↗
44. Construction of degradable multilayer films for enhanced antibacterial properties10.1021/am4000547 ↗
45. Reducing implant-related infections: active release strategies10.1039/b515219b ↗
46. Antibacterial coatings for improving the performance of biomaterials10.3390/coatings10020139 ↗
47. Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells10.1016/j.intimp.2011.02.016 ↗
48. Skin acute wound healing: a comprehensive review
49. What makes wounds chronic10.1016/j.suc.2020.05.001 ↗
50. Immune regulation of skin wound healing: mechanisms and novel therapeutic targets10.1089/wound.2017.0761 ↗
51. Polysaccharide-based in situ self-healing hydrogels for tissue engineering applications10.3390/polym12102261 ↗
52. Morphological, release and antibacterial performances of amoxicillin-loaded cellulose aerogels10.3390/molecules23082082 ↗
53. Self-healing chitosan/vanillin hydrogels based on schiff-base bond/hydrogen bond hybrid linkages10.1016/j.polymertesting.2018.01.016 ↗
54. Wound healing society 2015 update on guidelines for pressure ulcers10.1111/wrr.12396 ↗
55. Pressure ulcer/injury classification today: an international perspective10.1016/j.jtv.2020.04.003 ↗
56. Biocompatible hyaluronic acid-divinyl sulfone injectable hydrogels for sustained drug release with enhanced antibacterial properties against Staphylococcus aureus
57. Wound healing and antibacterial chitosan-genipin hydrogels with controlled drug delivery for synergistic anti-inflammatory activity10.1016/j.ijbiomac.2022.01.193 ↗
58. Sustained drug release from biopolymer-based hydrogels and hydrogel coatings
59. Drug delivery from hyaluronic Acid–BDDE injectable hydrogels for antibacterial and anti-inflammatory applications10.3390/gels8040223 ↗
60. Preparation and characterization of nanocellulose reinforced semi-interpenetrating polymer network of chitosan hydrogel10.1007/s10570-017-1251-8 ↗
61. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing10.1039/C7RA13510F ↗
62. Mechanisms of solute release from porous hydrophilic polymers10.1016/0378-5173(83)90064-9 ↗
63. Mathematical models in drug delivery : how modeling has shaped the way we design new drug delivery systems10.1016/j.jconrel.2014.06.041 ↗