Pathology-driven catalytic nanozyme–integrated adhesive hydrogel disrupts the hyperglycemia–ROS–hypoxia loop to accelerate vascularized fracture healing in diabetes
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (51)
Show source-provided references
1. Diabetes insipidus10.1038/s41572-019-0103-2 ↗
2. Genetics of diabetes mellitus and diabetes complications10.1038/s41581-020-0278-5 ↗
3. Bone fragility in diabetes: novel concepts and clinical implications10.1016/S2213-8587(21)00347-8 ↗
4. Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives10.1016/j.biomaterials.2018.07.017 ↗
5. Regulation of osteoimmune microenvironment and osteogenesis by 3D-printed PLAG/black phosphorus scaffolds for bone regeneration10.1002/advs.202302539 ↗
6. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus10.1038/s41574-021-00555-5 ↗
7. Emerging targets in type 2 diabetes and diabetic complications10.1002/advs.202100275 ↗
8. Molecular pathways associated with oxidative stress in diabetes mellitus10.1016/j.biopha.2018.09.058 ↗
9. Targeted management of diabetic osteoporosis by biocatalytic cascade reaction nanoplatform10.1021/acs.nanolett.4c05221 ↗
10. Macrophage polarization plays roles in bone formation instructed by calcium phosphate ceramics10.1039/C9TB02932J ↗
11. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage10.1038/35008121 ↗
12. FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition10.1016/j.redox.2022.102530 ↗
13. Oxidative stress and diabetic complications10.1161/CIRCRESAHA.110.223545 ↗
14. Advanced glycation end products and diabetes mellitus: mechanisms and perspectives10.3390/biom12040542 ↗
15. M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment10.1186/s12964-024-01560-7 ↗
16. Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization
17. Diabetes: a dynamic disease10.1016/S0140-6736(17)31537-4 ↗
18. Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration10.1038/s41467-025-65165-5 ↗
19. Adaptive smart hydrogels driving precision bone healing in pathological contexts10.1016/j.jconrel.2026.114617 ↗
20. A logic-based diagnostic and therapeutic hydrogel with Multistimuli responsiveness to orchestrate diabetic bone regeneration10.1002/adma.202108430 ↗
21. Dual-nanoparticle engineered hydrogel reverses bicellular oxidative stress to accelerate diabetic fracture healing10.1002/adfm.202506623 ↗
22. Injectable hydrogel for sustained delivery of progranulin derivative atsttrin in treating diabetic fracture healing10.1016/j.biomaterials.2023.122289 ↗
23. Injectable bioresponsive bone adhesive hydrogels inhibit NLRP3 inflammasome on demand to accelerate diabetic fracture healing
24. Quercetin derivatives: drug design, development, and biological activities, a review10.1016/j.ejmech.2021.114068 ↗
25. Single-cell RNA sequencing reveals a distinct profile of bone immune microenvironment and decreased osteoclast differentiation in type 2 diabetic mice
26. APEX1, a transcriptional hub for endochondral ossification and fracture repair10.1038/s41413-025-00486-1 ↗
27. Schottky engineering of GDYO@Pt to boost piezoelectric and oxidative stress modulation for accelerated cranial regeneration10.1038/s41467-025-63550-8 ↗
28. Photoacoustic imaging-guided self-adaptive hyperthermia supramolecular Cascade nano-reactor for diabetic periodontal bone regeneration
29. Recent advances in nanozymes: from matters to bioapplications10.1002/adfm.202110432 ↗
30. Biosystem-inspired engineering of nanozymes for biomedical applications10.1002/adma.202211147 ↗
31. ROS-reactive PMS/PC drug delivery system improves new bone formation under diabetic conditions by promoting angiogenesis-osteogenesis coupling via down-regulating NOX2-ROS signalling axis10.1016/j.biomaterials.2022.121900 ↗
32. Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair
33. Multifunctional polyoxomolybdate cluster loaded into hydrogel for augmented bone regeneration through synergistic immunomodulation and osteogenesis
34. ROS-responsive wedelolactone hydrogel promotes intervertebral disc repair by disrupting the NF-κB-LCN2 inflammatory feedback loop
35. A pilot study of conically graded chitosan-gelatin hydrogel/PLGA scaffold with dual-delivery of TGF-β1 and BMP-2 for regeneration of cartilage-bone interface10.1002/jbm.b.33314 ↗
36. Dual-biomimetic bone adhesive with osteoimmunomodulatory capabilities for anatomical reconstruction of comminuted fractures
37. Transverse tibial bone transport promotes distraction osteogenesis and improves blood flow in the management of diabetic foot10.4239/wjd.v17.i1.111847 ↗
38. Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes10.1007/s00125-015-3643-3 ↗
39. The key role of the blood supply to bone10.4248/BR201303001 ↗
40. HIF-1 at the crossroads of hypoxia, inflammation, and cancer10.1002/ijc.29519 ↗
41. Death by TNF: a road to inflammation10.1038/s41577-022-00792-3 ↗
42. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study10.1038/s41392-020-00312-6 ↗
43. Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties
44. Silicon enhances functional mitochondrial transfer to improve neurovascularization in diabetic bone regeneration
45. 1,2,4-Trimethoxybenzene alleviates cognitive dysfunction in type 2 diabetes model rats by inhibiting NLRP3 inflammasome and restoring gut microbiota disorders10.1016/j.bcp.2025.117409 ↗
46. Functional iron oxide nanoparticles cross-linked hydrogel for craniofacial bone regeneration
47. Role of advanced glycation end-products and oxidative stress in Type-2-Diabetes-Induced bone fragility and implications on fracture risk stratification10.3390/antiox12040928 ↗
48. CCR2-Engineered macrophage membrane-coated metal-polyphenol nanozyme to enhance antioxidation activity for inhibiting the atherosclerotic progression
49. MK-4 ameliorates diabetic osteoporosis in angiogenesis-dependent bone formation by promoting mitophagy in endothelial cells10.2147/DDDT.S503930 ↗
50. M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator
51. A universal metal-flavonoid coating strategy: engineering biomaterials for diabetic bone regeneration