Metal ion-based therapeutic strategies for diabetic wound healing: Mechanisms, biomaterial platforms, and translational challenges
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Wound Healing and Treatments · Nanoplatforms for cancer theranostics · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Diabetic foot ulcers: classification, risk factors and management10.4239/wjd.v13.i12.1049 ↗
2. Effectiveness and safety of dermal matrix used for diabetic foot ulcer: a systematic review and meta-analysis of randomized controlled trials10.1186/s12902-024-01550-3 ↗
3. Diabetic foot ulcer: a comprehensive review of pathophysiology and management modalities10.12998/wjcc.v11.i8.1684 ↗
4. Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers10.2337/dci22-0043 ↗
5. [Research on the pathogenesis and treatment of diabetic foot ulcer wounds]
6. Metal ion formulations for diabetic wound healing: mechanisms and therapeutic potential
7. Metal-organic frameworks for diabetic wound healing
8. Metal nanoparticles: advanced and promising technology in diabetic wound therapy10.2147/IJN.S434693 ↗
9. Sustained releasable copper and zinc biogenic ions Co-Assembled in metal-organic frameworks reinforced bacterial eradication and wound mitigation in diabetic mice10.1021/acs.bioconjchem.3c00325 ↗
10. Effective diabetic wound prohealing by supramolecular ROS-responsive hyaluronic acid hydrogels via in situ production of nitric oxide and oxygen10.1039/D5TB01828E ↗
11. Advancements in wound dressing materials: highlighting recent progress in hydrogels, foams, and antimicrobial dressings10.3390/gels11020123 ↗
12. MOFs and MOF-derived materials for antibacterial application10.3390/jfb13040215 ↗
13. Mechanisms of diabetic foot ulceration: a review10.1111/1753-0407.13372 ↗
14. Targeting the AGEs-RAGE axis: pathogenic mechanisms and therapeutic interventions in diabetic wound healing
15. AGEs-induced MMP-9 activation mediated by Notch1 signaling is involved in impaired wound healing in diabetic rats10.1016/j.diabres.2022.109831 ↗
16. Keratinocyte-derived small extracellular vesicles delay diabetic wound healing by triggering fibroblasts autophagy10.1080/13813455.2024.2358020 ↗
17. Macrophage and neutrophil dysfunction in diabetic wounds10.1089/wound.2023.0149 ↗
18. Chronic diabetic wounds and their treatment with skin substitutes10.3390/cells10030655 ↗
19. Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies
20. Role of matrix metalloproteinases in diabetic foot ulcers: potential therapeutic targets10.3389/fphar.2022.1050630 ↗
21. Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction10.1186/s12964-022-01016-w ↗
22. Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications
23. Sulforaphane promotes diabetic wound healing by regulating macrophage efferocytosis and polarization10.1016/j.intimp.2025.114243 ↗
24. Biofilms in diabetic foot ulcers: impact, risk factors and control strategies10.3390/ijms22158278 ↗
25. Biofilms in diabetic foot ulcers: significance and clinical relevance10.3390/microorganisms8101580 ↗
26. N6-Methyladenosine modification of lncCCKAR-5 regulates autophagy in human umbilical cord mesenchymal stem cells by destabilizing LMNA and inhibits diabetic wound healing10.1016/j.jid.2023.11.023 ↗
27. Integrating untargeted metabolomics revealed ferulic acid treatment on endothelial progenitor cells mediated vascular dysfunction following diabetic wound10.1096/fj.202402820R ↗
28. The role of mesenchymal stem cell-derived EVs in diabetic wound healing
29. Wound pH-Modulating strategies for diabetic wound healing10.1089/wound.2023.0129 ↗
30. Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing10.1016/j.msec.2020.111022 ↗
31. IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023)10.1002/dmrr.3687 ↗
32. Bacteriological profile of diabetic wounds at Laquintinie hospital douala and the antimicrobial potential of spiced fish (Fontitrygon margarita) liver oil against multiresistant isolates10.1155/bmri/3158942 ↗
33. Isolation and drug susceptibility pattern of uropathogens in Saudi diabetic and non-diabetic patients with urinary tract infection10.6026/97320630018710 ↗
34. Bacteriological profile of diabetic foot ulcer with special reference to biofilm formation
35. Antimicrobial resistance of uropathogens in diabetic patients10.1186/s12879-025-11358-8 ↗
36. Infection characteristics and drug susceptibility of multidrug-resistant bacteria in patients with diabetic foot ulcers
37. Prevalence and antibiotic resistance of Klebsiella pneumoniae in diabetic foot ulcer
38. Diabetes-related foot infections: diagnosis and treatment
39. Local antibiotics in the treatment of diabetic foot infections: a narrative review10.3390/antibiotics12010124 ↗
40. The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: a protocol for systematic review and meta-analysis
41. Occurrence of major local lower limb events in type 2 diabetic patients with lower extremity arterial disease: impact of metformin10.1016/j.avsg.2022.09.064 ↗
42. GPCRs as key regulators in wound healing
43. Non-surgical treatment for arterial leg ulcers: a narrative review10.12968/jowc.2022.31.11.969 ↗
44. Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice10.4239/wjd.v13.i8.600 ↗
45. Electrospun fiber membranes modified with heparin and parathyroid hormone derivative to promote diabetic wound healing10.1002/mabi.202400608 ↗
46. Effects of cilostazol and aspirin on diabetic foot ulcer and peripheral artery disease: a retrospective study
47. Rational analysis of the utilization of pentoxifylline in a tertiary hospital: Central hospital affiliated to Shandong first medical university10.2147/RMHP.S517679 ↗
48. Cilostazol ameliorates motor dysfunction and Schwann cell impairment in Streptozotocin-induced diabetic rats10.3390/ijms25147847 ↗
49. Evaluation of outcomes following hospital-wide implementation of a subcutaneous insulin protocol for diabetic ketoacidosis10.1001/jamanetworkopen.2022.6417 ↗
50. pH/Glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing10.1021/acsnano.1c11040 ↗
51. Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors10.1038/s41581-021-00393-8 ↗
52. Managing diabetic foot ulcers: pharmacotherapy for wound healing10.1007/s40265-020-01415-8 ↗
53. GLP-1 receptor agonists and diabetic retinopathy: a meta-analysis of randomized clinical trials10.1016/j.survophthal.2023.07.002 ↗
54. VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes10.1038/s41536-021-00189-1 ↗
55. Diagnostic significance of serum VEGF, bFGF, and wound tissue EGFR in diabetic chronic refractory wounds10.1177/15347346241313010 ↗
56. Comparative efficacy of growth factor therapy in healing diabetes-related foot ulcers: a network meta-analysis of randomized controlled trials10.1002/dmrr.3670 ↗
57. Comparison of the efficacy and safety of different growth factors in the treatment of diabetic foot ulcers: an updated network meta-analysis10.3389/fendo.2025.1614597 ↗
58. Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease (2020 edition)
59. Efficacy and safety of biomaterials and antimicrobial dressings in the treatment of diabetic foot ulcers: a systematic review and network meta-analysis10.1155/jdr/1548984 ↗
60. Extracellular matrix repair and organization of chronic infected diabetic wounds treated with methacrylated chitosan-based hydrogels10.1016/j.actbio.2025.04.062 ↗
61. Silver sulfadiazine eradicates antibiotic-tolerant Staphylococcus aureus and Pseudomonas aeruginosa biofilms in patients with infected diabetic foot ulcers10.3390/jcm9123807 ↗
62. Contribution of topical agents such as hyaluronic acid and silver sulfadiazine to wound healing and management of bacterial biofilm10.3390/medicina58060835 ↗
63. Proteomics and transcriptomics explore the effect of mixture of herbal extract on diabetic wound healing process10.1016/j.phymed.2023.154892 ↗
64. Urea in dermatology: a review of its emollient, moisturizing, keratolytic, skin barrier enhancing and antimicrobial properties10.1007/s13555-021-00611-y ↗
65. The use of timolol for wound healing—A review10.1007/s13671-024-00421-3 ↗
66. Case report: rehabilitation after platelet-rich growth factors' intra-articular injections for knee osteoarthritis: two case reports of a home-based protocol10.3389/fphar.2021.718060 ↗
67. Innate immunity and wound repair: the platelet-rich fibrin advantage10.4331/wjbc.v16.i2.107195 ↗
68. Platelet-rich plasma for wound healing in diabetic patients10.3390/medicina61091535 ↗
69. Platelet-rich plasma-derived exosomes accelerate the healing of diabetic foot ulcers by promoting macrophage polarization toward the M2 phenotype10.1007/s10238-025-01651-w ↗
70. Bioengineered skin for diabetic foot ulcers: a scoping review10.3390/jcm13051221 ↗
71. Reframing chronic wound therapy: from growth factor delivery to regenerative immuno-engineering
72. Skin substitutes as treatment for chronic wounds: current and future directions10.3389/fmed.2023.1154567 ↗
73. Diabetes potentiates the emergence and expansion of antibiotic resistance10.1126/sciadv.ads1591 ↗
74. Antidepressant- and anxiolytic-like effects of linezolid in streptozotocin-induced diabetic mice via modulation of brain serotonin and plasma corticosterone activity10.1016/j.bbrc.2025.151843 ↗
75. Efficacy of topical cadexomer iodine treatment in chronic wounds: systematic review and meta-analysis of comparative clinical trials10.1111/iwj.13560 ↗
76. Efficacy of hyaluronic acid/collagenase ointment in the treatment of chronic wounds: a retrospective observational study10.1177/15347346241243102 ↗
77. Healing diabetic foot ulcers with topical timolol improves healed epithelial integrity10.1159/000545357 ↗
78. Composite biomaterials of polyelectrolyte complex micelle nanoparticles in hyaluronic acid gels enable local, targeted miR-92a inhibition and enhanced angiogenesis in diabetic wound repair10.1016/j.jconrel.2026.115031 ↗
79. Current status and progress in research on dressing management for diabetic foot ulcer10.3389/fendo.2023.1221705 ↗
80. Negative pressure wound therapy (NPWT) is superior to conventional moist dressings in wound bed preparation for diabetic foot ulcers: a randomized controlled trial10.15537/smj.2023.44.20230386 ↗
81. The effects of silver-releasing foam dressings on diabetic foot ulcer healing10.3390/jcm10071495 ↗
82. Negative pressure wound therapy: mechanism of action and clinical applications10.1055/s-0041-1731792 ↗
83. Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis10.1016/j.lfs.2020.118246 ↗
84. E. coli and S. aureus resist silver nanoparticles via an identical mechanism, but through different pathways10.1038/s42003-024-07266-3 ↗
85. Antibacterial effect of silver nanoparticles against four foodborne pathogens10.5812/jjm.8720 ↗
86. Salvadora persica mediated synthesis of silver nanoparticles and their antimicrobial efficacy10.1038/s41598-021-85584-w ↗
87. The antibacterial mechanism of silver nanoparticles and its application in dentistry10.2147/IJN.S246764 ↗
88. Beneficial effect of wound dressings containing silver and silver nanoparticles in wound healing-from experimental studies to clinical practice10.3390/life13010069 ↗
89. Silver nanoparticles and its mechanistic insight for chronic wound healing: review on recent progress10.3390/molecules27175587 ↗
90. Phytofabricated Farsetia aegyptia-derived silver nanoparticles mediate antibacterial and wound-healing activities in diabetic foot infection rat model10.1007/s10787-025-01789-9 ↗
91. Recent advances of silver nanoparticles in wound healing: evaluation of in vivo and in vitro studies10.3390/ijms26209889 ↗
92. Silk fibroin methacryloyl hydrogel loaded with silver-gallic acid nanoparticles for enhanced diabetic wound healing
93. Biogenic silver nanoparticles: revolutionizing diabetic wound therapy10.2174/0122117385394646251111112131 ↗
94. Wireless matrix metalloproteinase-9 sensing by smart wound dressing with controlled antibacterial nanoparticles release toward chronic wound management10.1016/j.bios.2024.116860 ↗
95. Advancing biomedical applications: an in-depth analysis of silver nanoparticles in antimicrobial, anticancer, and wound healing roles10.3389/fphar.2024.1438227 ↗
96. Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair
97. Plasmon-enhanced peroxidase-like activity of nitrogen-doped graphdiyne oxide quantum dots/gold–silver nanocage heterostructures for antimicrobial applications10.1021/acs.chemmater.1c03952 ↗
98. Low-temperature photothermal therapy based on borneol-containing polymer-modified MXene nanosheets10.1021/acsami.2c12839 ↗
99. PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation10.1016/j.biomaterials.2020.119936 ↗
100. Electrical stimulation-based conductive hydrogel for immunoregulation, neuroregeneration and rapid angiogenesis in diabetic wound repair10.1007/s40843-022-2242-y ↗