A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Osteoarthritis Treatment and Mechanisms · RNA Interference and Gene Delivery · Metabolism, Diabetes, and Cancer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (51)
Show source-provided references
1. 2022-2050: a forecasting analysis for the global burden of disease study 202110.1016/S0140-6736(24)00685-8 ↗
2. Osteoarthritis as a systemic disease
3. Trends and cross-country inequalities in the global burden of osteoarthritis, 1990-2019: a population-based study10.1016/j.arr.2024.102382 ↗
4. Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis10.1038/s41413-024-00375-z ↗
5. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment10.1038/nm.4324 ↗
6. The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies10.1038/s41413-025-00460-x ↗
7. Mitochondrial dysfunction in cell senescence and aging10.1172/JCI158447 ↗
8. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis10.1038/s41584-020-00533-7 ↗
9. Cellular and molecular mechanisms of metformin action10.1210/endrev/bnaa023 ↗
10. AMPK: the energy sensor at the crossroads of aging and cancer10.1016/j.semcancer.2024.08.002 ↗
11. Benefits of metformin in attenuating the hallmarks of aging10.1016/j.cmet.2020.04.001 ↗
12. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network10.1016/j.arr.2011.12.005 ↗
13. Metformin limits osteoarthritis development and progression through activation of AMPK signalling10.1136/annrheumdis-2019-216713 ↗
14. Zwitterion-lubricated hydrogel microspheres encapsulated with metformin ameliorate age-associated osteoarthritis10.1002/advs.202402477 ↗
15. Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration10.1038/s41413-025-00411-6 ↗
16. Metformin for treatment of knee osteoarthritis in patients with overweight or obesity10.1001/jama.2025.10711 ↗
17. Metformin for knee osteoarthritis … and other research
18. Metformin: update on mechanisms of action and repurposing potential10.1038/s41574-023-00833-4 ↗
19. Metformin biodistribution: a key to mechanisms of action?10.1210/clinem/dgaa332 ↗
20. In vivo imaging of human 11C-Metformin in peripheral organs: dosimetry, biodistribution, and kinetic analyses10.2967/jnumed.116.177774 ↗
21. Pharmacokinetics of metformin after intravenous and oral administration to man10.1007/BF00562061 ↗
22. Osteoarthritis: pathogenic signaling pathways and therapeutic targets10.1038/s41392-023-01330-w ↗
23. Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy10.1016/j.biomaterials.2025.123210 ↗
24. Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance10.1016/j.jconrel.2020.11.050 ↗
25. Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery10.2174/1389201015666140617092552 ↗
26. Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release10.1016/j.addr.2024.115239 ↗
27. A dynamic DNA tetrahedron framework for active targeting10.1038/s41596-022-00791-7 ↗
28. Framework nucleic acid-based and neutrophil-based nanoplatform loading baicalin with targeted drug delivery for anti-inflammation treatment10.1021/acsnano.4c12917 ↗
29. Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis10.1038/s41413-019-0077-4 ↗
30. Cartilage-penetrating framework nucleic acid nanoparticles ameliorate osteoarthritis by promoting drug delivery and chondrocyte uptake
31. Tetrahedral framework nucleic acid carrying angiogenic peptide prevents bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis10.1038/s41368-022-00171-7 ↗
32. Injectable microgels with hybrid exosomes of chondrocyte-targeted FGF18 gene-editing and self-renewable lubrication for osteoarthritis therapy
33. Physical chemistry of nucleic acids10.1146/annurev.physchem.53.082001.144341 ↗
34. Single-particle tracking and modulation of cell entry pathways of a tetrahedral DNA nanostructure in live cells10.1002/anie.201403236 ↗
35. Cartilage-targeted drug nanocarriers for osteoarthritis therapy10.1016/j.ijpharm.2024.124843 ↗
36. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy10.1016/j.jsb.2003.08.006 ↗
37. Topographic features of nano-pores within the osteochondral interface and their effects on transport properties -a 3D imaging and modeling study10.1016/j.jbiomech.2021.110504 ↗
38. Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display10.1016/j.biomaterials.2011.05.017 ↗
39. Functionalizing framework nucleic-acid-based nanostructures for biomedical application
40. Pharmacokinetics of metformin after intravenous and oral administration to man10.1007/BF00562061 ↗
41. An injectable self-lubricating supramolecular polymer hydrogel loaded with platelet lysate to boost osteoarthritis treatment10.1016/j.jconrel.2024.09.052 ↗
42. Inflammation and DNA damage: cause, effect or both10.1038/s41584-022-00905-1 ↗
43. Cellular senescence and other age-related mechanisms in skeletal diseases10.1038/s41413-025-00448-7 ↗
44. Mitochondrial degradation: mitophagy and beyond10.1016/j.molcel.2023.08.021 ↗
45. Mitophagy in human health, ageing and disease10.1038/s42255-023-00930-8 ↗
46. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis10.1111/j.1749-6632.2009.05240.x ↗
47. Osteoarthritis10.1016/S0140-6736(19)30417-9 ↗
48. Cartilage-targeting ultrasmall lipid-polymer hybrid nanoparticles for the prevention of cartilage degradation10.1002/btm2.10187 ↗
49. Bioinspired lipid nanoparticles with prolonged cartilage retention boost regeneration in early osteoarthritis and large cartilage defects10.1021/acsnano.4c13828 ↗
50. Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration10.1016/j.jconrel.2024.04.009 ↗
51. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse10.1016/j.joca.2010.05.025 ↗